Results 11 to 20 of about 1,916,955 (263)
Impact of chronic alcohol exposure on conventional and regulatory murine T cell subsets
Frontiers in Immunology, 2023 IntroductionChronic alcohol use poses significant negative consequences to public health and, among its many biologic effects, is associated with significant T cell dysregulation within the adaptive immune system that has yet to be fully characterized ...
Cameron W. Paterson +7 more
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Saturated very long-chain fatty acids regulate macrophage plasticity and invasiveness
Journal of Neuroinflammation, 2022 Saturated very long-chain fatty acids (VLCFA, ≥ C22), enriched in brain myelin and innate immune cells, accumulate in X-linked adrenoleukodystrophy (X-ALD) due to inherited dysfunction of the peroxisomal VLCFA transporter ABCD1.
Bettina Zierfuss +15 more
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Cell Cycle Entry Control in Naïve and Memory CD8+ T Cells
Frontiers in Cell and Developmental Biology, 2021 CD8+ T cells play important roles in immunity and immuno-oncology. Upon antigen recognition and co-stimulation, naïve CD8+ T cells escape from dormancy to engage in a complex programme of cellular growth, cell cycle entry and differentiation, resulting ...
David A. Lewis, Tony Ly, Tony Ly
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TNF activity and T cells [PDF]
Cytokine, 2018 TNF (tumor necrosis factor) is both a pro-inflammatory and anti-inflammatory cytokine that is central to the development of autoimmune disease, cancer, and protection against infectious pathogens. As well as a myriad other activities, TNF can be a product of T cells and can act on T cells.
Amit K, Mehta +2 more
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Not All Immune Checkpoints Are Created Equal
Frontiers in Immunology, 2018 Antibodies that block T cell inhibition via the immune checkpoints CTLA-4 and PD-1 have revolutionized cancer therapy during the last 15 years. T cells express additional inhibitory surface receptors that are considered to have potential as targets in ...
Annika De Sousa Linhares +3 more
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Journal of Nuclear Medicine, 2022 The adaptive immune response plays a critical role in detecting, eliminating, and creating a memory toward foreign pathogens and malignant cells. Demonstration of the specific and effective target killing of T cells in cancer has reignited interest in the study and therapeutic manipulation of the interaction between tumor and immune system.
Sako, Mohammad O., Larimer, Benjamin M.
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Tethering of vesicles to the Golgi by GMAP210 controls LAT delivery to the immune synapse
Nature Communications, 2019 The immune synapse at the interface between T cells and antigen-presenting cells manifests intense vesicular trafficking, but how the vesicles are sorted is still unclear.
Andres Ernesto Zucchetti +10 more
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Discovery of the first PD-1 ligand encoded by a pathogen
Frontiers in Immunology, 2022 Large double-stranded DNA viruses deploy multiple strategies to subvert host immune defenses. Some of these tactics are mediated by viral gene products acquired by horizontal gene transfer from the corresponding hosts and shaped throughout evolution. The
Pablo Martínez-Vicente +8 more
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Neuropilin-1 Acts as a Receptor for Complement Split Products
Frontiers in Immunology, 2019 Complement split products (CSPs), such as the fragments C4d and C3d, which are generated as a consequence of complement regulatory processes, are established markers for disease activity in autoimmunity or antibody-mediated graft rejection.
Claire Battin +9 more
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T Cell Membrane Heterogeneity Aids Antigen Recognition and T Cell Activation
Frontiers in Cell and Developmental Biology, 2020 T cells are critical for co-ordinating the immune response. T cells are activated when their surface T cell receptors (TCRs) engage cognate antigens in the form of peptide-major histocompatibility complexes (pMHC) presented on the surface of antigen ...
Megan V. Farrell +7 more
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