Results 41 to 50 of about 1,940,376 (313)

Evaluating STAT5 Phosphorylation as a Mean to Assess T Cell Proliferation

Frontiers in Immunology, 2019
Here we present a simple and sensitive flow cytometric—based assay to assess T cell proliferation. Given the critical role STAT5A phosphorylation in T cell proliferation, we decided to evaluate phosphorylation of STAT5A as an indicator of T cell ...
Michael Bitar, Andreas Boldt, Marie-Theres Freitag, Bernd Gruhn, Ulrike Köhl, Ulrike Köhl, Ulrike Köhl, Ulrich Sack   +7 more
doaj   +1 more source

Multiplex T Cell Stimulation Assay Utilizing a T Cell Activation Reporter-Based Detection System

Frontiers in Immunology, 2020
Recent advancements in single cell sequencing technologies allow for identification of numerous immune-receptors expressed by T cells such as tumor-specific and autoimmune T cells.
Sarah E. Mann, Zhicheng Zhou, Laurie G. Landry, Amanda M. Anderson, Aimon K. Alkanani, Jeremy Fischer, Mark Peakman, Roberto Mallone, Roberto Mallone, Kristen Campbell, Aaron W. Michels, Aaron W. Michels, Maki Nakayama, Maki Nakayama, Maki Nakayama   +14 more
doaj   +1 more source

Low levels of peripheral blood activated and senescent T cells characterize people with HIV-1-associated neurocognitive disorders

Frontiers in Immunology, 2023
BackgroundHIV infection induces a 75% increase in the risk of developing neurocognitive impairment (NCI), which has been linked to immune activation. We therefore looked for immune activation markers correlating with NCI.MethodSixty-five people aged 55 ...
Lucy Kundura, Renaud Cezar, Manuela Pastore, Christelle Reynes, Jérémy Deverdun, Emmanuelle Le Bars, Emmanuelle Le Bars, Albert Sotto, Albert Sotto, Jacques Reynes, Jacques Reynes, Alain Makinson, Alain Makinson, Pierre Corbeau, Pierre Corbeau, Pierre Corbeau   +15 more
doaj   +1 more source

Transcriptional reprogramming via signaling domains of CD2, CD28, and 4-1BB

iScience
Summary: Costimulatory signals provided to T cells during antigen encounter have a decisive role in the outcome of immune responses. Here, we used chimeric receptors harboring the extracellular domain of mouse inducible T cell costimulator (mICOS) to ...
Annika De Sousa Linhares, Sumana Sharma, Peter Steinberger, Judith Leitner   +3 more
doaj   +1 more source

Easy or Not—The Advances of EZH2 in Regulating T Cell Development, Differentiation, and Activation in Antitumor Immunity

Frontiers in Immunology, 2021
Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of polycomb repressive complex 2 (PRC2), which regulates downstream gene expression by trimethylation of lysine 27 in histone H3 (H3K27me3). EZH2 mutations or overexpressions are associated with
Jiaqi Huang, Jiaqi Huang, Jie Zhang, Zhengyang Guo, Chen Li, Chen Li, Zhen Tan, Junjie Wang, Jianling Yang, Lixiang Xue, Lixiang Xue   +10 more
doaj   +1 more source

Natural killer cells promote early CD8 T cell responses against cytomegalovirus. [PDF]

, 2007
Understanding the mechanisms that help promote protective immune responses to pathogens is a major challenge in biomedical research and an important goal for the design of innovative therapeutic or vaccination strategies.
Sacher, Torsten, Ulrich H Koszinowski, Rupp Brigitte, Eric Vivier, Ruzsics, Zsolt, Koszinowski Ulrich H, Cornillon, Amélie, Dalod Marc, Bessou Gilles, Koszinowski, Ulrich H, Marc Dalod, Sacher Torsten, Robbins, Scott H., Torsten Sacher, Tomasello Elena, Dalod, Marc, Scott H Robbins, Nicolas Zucchini, Ruzsics Zsolt, Koszinowski, Ulrich H., Zsolt Ruzsics, Elena Tomasello, Gilles Bessou, Bessou, Gilles, Tomasello, Elena, Cornillon Amélie, Vivier Eric, Vivier, Eric, Zucchini, Nicolas, Amélie Cornillon, Brigitte Rupp, Zucchini Nicolas, Robbins, Scott H, Robbins Scott H, Rupp, Brigitte   +34 more
core   +1 more source

Heterogeneity in the Global Practice of Central Nervous System Staging in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási, Bernadett Borbála Huszti, Gábor Barna, Marko Kavcic, Janez Jazbec, Lennart Lenk, Vera Münch, Sophia Polychronopoulou, Ágnes Márk, Maria Thastrup, Lüder H. Meyer, Kjeld Schmiegelow, Cornelia Eckert, Christina Halsey, Dániel J. Erdélyi   +14 more
wiley   +1 more source

CVID-associated TACI mutations affect autoreactive B cell selection and activation [PDF]

, 2013
Common variable immune deficiency (CVID) is an assorted group of primary diseases that clinically manifest with antibody deficiency, infection susceptibility, and autoimmunity.
Tuure Kinnunen, Gentile, M, Cantaert, T, Tineke Cantaert, Menard, L, Laurence Menard, Morbach, H, Saadoun, D, Virdee, M, Neil Romberg, Kinnunen, T, Maurizio Gentile, Rachid, R, Martinez-Pomar, N, Geha, R, Henner Morbach, Matamoros, N, Cunningham-Rundles, C, Nicolas Chamberlain, Nuria Matamoros, Andrea Cerutti, Yen Shing Ng, Bodo Grimbacher, Natalia Martinez-Pomar, Meffre, E, Eric Meffre, David Saadoun, Manmeet Virdee, Rima Rachid, Cerutti, A, Raif Geha, Romberg, N, Brimbacher, B, Chamberlain, N, Charlotte Cunningham-Rundles, Ng, YS   +35 more
core   +1 more source

T cell activation and effector function in the human Jurkat T cell model.

, 2022
In order to understand T cell function, it is necessary to completely decipher the molecular dynamics underlying T cell activation and effector function.
Martín-Cófreces, Noa Beatriz, Carrasco-Padilla, C, Alegre-Gómez, S, Roda-Navarro, Pedro, Martín Cófreces, Noa Beatriz, Gómez-Morón, Alvaro, Sánchez Madrid, Francisco, Aguilar-Sopeña, O, Gómez Morón, Alvaro, Roda Navarro, Pedro, Sánchez-Madrid, Francisco, Alegre Gómez, Sergio, Carrasco Padilla, C, Aguilar Sopeña, O   +13 more
core   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source