Results 21 to 30 of about 1,916,955 (263)
Frontiers in Immunology, 2022 Upon antigen recognition by the T cell receptor (TCR), a complex signaling network orchestrated by protein-tyrosine kinases (PTKs) and protein-tyrosine phosphatases (PTPs) regulates the transmission of the extracellular signal to the nucleus. The role of
Clemens Cammann +17 more
doaj +1 more source
T Cell Activation and the Cytoskeleton
Annual Review of Immunology, 2000 Ligation of the T cell antigen receptor (TCR) stimulates protein tyrosine kinases (PTKs), which regulate intracellular calcium and control the activity of protein kinase C (PKC) isozymes. PTKs activated by antigen receptors and costimulatory molecules also couple to phosphatidylinositol-3 kinase (PI3K) and control the activity of Ras- and Rho-family ...
Acuto, Oreste, Cantrell, Doreen
openaire +3 more sources
Frontiers in Immunology, 2017 Immune checkpoint inhibitors, which target coinhibitory T cell molecules to promote anticancer immune responses, are on the rise to become a new pillar of cancer therapy.
Carmen Stecher +7 more
doaj +1 more source
Specific T-cell Activation in an Unspecific T-cell Repertoire [PDF]
Science Progress, 2011 T-cells are a vital type of white blood cell that circulate around our bodies, scanning for cellular abnormalities and infections. They recognise disease-associated antigens via a surface receptor called the T-cell antigen receptor (TCR). If there were a specific TCR for every single antigen, no mammal could possibly contain all the T-cells it needs ...
Berg, Hugo van den +2 more
openaire +2 more sources
Robust T cell activation requires an eIF3-driven burst in T cell receptor translation
eLife, 2021 Activation of T cells requires a rapid surge in cellular protein synthesis. However, the role of translation initiation in the early induction of specific genes remains unclear. Here, we show human translation initiation factor eIF3 interacts with select
Dasmanthie De Silva +10 more
doaj +1 more source
Role of LFA-1 integrin in the control of a lymphocytic choriomeningitis virus (LCMV) infection
Virulence, 2020 Leukocyte function-associated antigen 1 (LFA-1) is the most widely expressed member of the β2 integrin family of cell-cell adhesion molecules. Although LFA-1 is thought to regulate multiple aspects of T cell immunity, its role in the response of CD8+ T ...
Mario Perro +3 more
doaj +1 more source
Mitochondrial activity in T cells
Mitochondrion, 2018 Mitochondria fulfill important and diverse roles during the different stages of T cell adaptive responses. Here we discuss the role of the mitochondria in T cells from the initial steps of activation at the immune synapse to their participation in memory response and T cell exhaustion. Mitochondria are relocated to the immune synapse in order to supply
Desdín-Micó, Gabriela +2 more
openaire +2 more sources
Evaluating STAT5 Phosphorylation as a Mean to Assess T Cell Proliferation
Frontiers in Immunology, 2019 Here we present a simple and sensitive flow cytometric—based assay to assess T cell proliferation. Given the critical role STAT5A phosphorylation in T cell proliferation, we decided to evaluate phosphorylation of STAT5A as an indicator of T cell ...
Michael Bitar +7 more
doaj +1 more source
Blinatumomab-induced T cell activation at single cell transcriptome resolution
BMC Genomics, 2021 Background Bi-specific T-cell engager (BiTE) antibody is a class of bispecific antibodies designed for cancer immunotherapy. Blinatumomab is the first approved BiTE to treat acute B cell lymphoblastic leukemia (B-ALL).
Yi Huo +8 more
doaj +1 more source
Stochastic modelling of T-cell activation [PDF]
Journal of Mathematical Biology, 2014 We investigate a special part of the human immune system, namely the activation of T-Cells, using stochastic tools, especially sharp large deviation results. T-Cells have to distinguish reliably between foreign and self peptides which are both presented to them by antigen presenting cells.
Mayer, Hannah, Bovier, Anton
openaire +4 more sources