Results 1 to 10 of about 2,807 (69)
تأثیر 4 هفته تمرین هوازی بر سطوح Trk-B ، PKC و AKT در هیپوکمپ رتهای نر مبتلا به بیماری آلزایمر [PDF]
فیزیولوژی ورزشی, 2021 واکنشهای تخریبی ناشی از AB در CNS منجر به اختلال فاکتورهای نوروتروفیک می شود که ممکن است به نوبه خود توسعه پاتولوژی آمیلوئید را تسهیل کند. اخیراً آثار ورزش بر این عوامل مورد توجه قرار گرفته است، با اینحال درک چگونگی اثر آن نیاز به بررسی بیشتر دارد ...
اصلان خدامرادی +2 more
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A PKC-based security architecture for WSN [PDF]
MATEC Web of Conferences, 2020 It is an important challenge to find out suitable cryptography for WSN due to limitations of energy, computation capability and storage resources. Considering this sensor feature on limitations of resources, a security architecture based-on public key ...
Yao Jianbo, Yang Chaoqiong
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Phosphorylation of the amino-terminus of the AGC kinase Gad8 prevents its interaction with TORC2 [PDF]
Open Biology, 2016 Cell proliferation, metabolism, migration and survival are coordinated through the tight control of two target of rapamycin (TOR) kinase complexes: TORC1 and TORC2.
Wei Du +3 more
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Insights into Activation Mechanisms of Store-Operated TRPC1 Channels in Vascular Smooth Muscle
Cells, 2020 In vascular smooth muscle cells (VMSCs), the stimulation of store-operated channels (SOCs) mediate Ca2+ influx pathways which regulate important cellular functions including contraction, proliferation, migration, and growth that are associated with the ...
Miguel A. S. Martín-Aragón Baudel +3 more
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Protein Kinase C Life Cycle: Explained Through Systems Biology Approach
Frontiers in Physiology, 2022 Protein kinase C (PKC) enzymes are a family of kinases that mediate signal transduction originating at the cell surface. Most cell membranes can contain functional PKC enzymes.
Naveed Aslam, Farah Alvi, Farah Alvi
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Biomolecules, 2020 Acute hypertension produced by methamphetamine (MA) is well known, mainly by the enhancement of catecholamine release from sympathetic terminals. However, the central pressor mechanism of the blood-brain-barrier-penetrating molecule remains unclear.
Chih-Chia Lai +4 more
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Cadmium induces CCL2 production in glioblastoma cells via activation of MAPK, PI3K, and PKC pathways
Journal of Immunotoxicology, 2020 Cadmium (Cd) is accumulated in human astrocytes and induces the production of interleukin (IL)-6 and IL-8. Astrocytes are one of the major sources of chemokine C–C motif ligand 2 (CCL2; known as monocyte chemoattractant protein-1 [MCP-1]), in the brain ...
Thitima Kasemsuk +4 more
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Activators and Inhibitors of Protein Kinase C (PKC): Their Applications in Clinical Trials
Pharmaceutics, 2021 Protein kinase C (PKC), a family of phospholipid-dependent serine/threonine kinase, is classed into three subfamilies based on their structural and activation characteristics: conventional or classic PKC isozymes (cPKCs; α, βI, βII, and γ), novel or non ...
Takahito Kawano +4 more
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Protein Kinase C at the Crossroad of Mutations, Cancer, Targeted Therapy and Immune Response
Biology, 2023 The frequent PKC dysregulations observed in many tumors have made these enzymes natural targets for anticancer applications. Nevertheless, this considerable interest in the development of PKC modulators has not led to the expected therapeutic benefits ...
Angelo Aquino +3 more
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Cells, 2020 Oxidative stress is a main molecular mechanism that underlies cardiovascular diseases. A close relationship between reactive oxygen species (ROS) derived from NADPH oxidase (NOX) activity and the prostaglandin (PG) biosynthesis pathway has been described.
Javier Marqués +8 more
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