Results 31 to 40 of about 97,124 (258)

Passage time, apparent metabolisable energy and ileal amino acids digestibility of treated palm kernel cake in broilers under the hot and humid tropical climate

Italian Journal of Animal Science, 2020
Four different palm kernel cake (PKC) including untreated PKC, enzyme fermented PKC (EPKC), extruded PKC (XPKC) and lactic acid bacteria fermented PKC (LPKC) were compared for their passage (ROP), apparent metabolisable energy (AME) and apparent ileal ...
Ali Hanafiah Hakim, Idrus Zulkifli, Abdoreza Soleimani Farjam, Elmutaz Atta Awad, Norhani Abdullah, Wei Li Chen, Rosfarizan Mohamad   +6 more
doaj   +1 more source

Novel regulation of PKC-induced inflammation by Akt and protein phosphatase 2A in ovarian granulosa cells

Chinese Journal of Physiology, 2020
PKC-mediated inflammation is important in ovarian physiology. The roles of Akt and protein phosphatase 2A (PP2A) in PKC-mediated inflammation in ovarian granulosa cells (GCs) remain mostly unclear.
Yen-Yu Lin, David Sun, Yuh-Lin Wu
doaj   +1 more source

Role and Mechanism of PKC-δ for Cardiovascular Disease: Current Status and Perspective

Frontiers in Cardiovascular Medicine, 2022
Protein kinase C (PKC) is a protein kinase with important cellular functions. PKC-δ, a member of the novel PKC subfamily, has been well-documented over the years.
Li-na Miao, Li-na Miao, Deng Pan, Deng Pan, Junhe Shi, Jian-peng Du, Jian-peng Du, Peng-fei Chen, Jie Gao, Jie Gao, Yanqiao Yu, Yanqiao Yu, Da-Zhuo Shi, Da-Zhuo Shi, Ming Guo, Ming Guo   +15 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Expression of protein kinase C isozymes in guinea pig epidermis: selective inhibition of PKC-beta activity by 13-hydroxyoctadecadienoic acid-containing diacylglycerol.

Journal of Lipid Research, 1994
Prompted by the reversal of skin hyperproliferation to normal by 13-hydroxyoctadecadienoic acid (13-HODE), a 15-lipoxygenase metabolite of linoleic acid, we investigated a possible mechanism for this antiproliferative action.
Y Cho, V A Ziboh
doaj   +1 more source

Loss of protein kinase C-δ protects against LPS-induced osteolysis owing to an intrinsic defect in osteoclastic bone resorption. [PDF]

PLoS ONE, 2013
Bone remodeling is intrinsically regulated by cell signaling molecules. The Protein Kinase C (PKC) family of serine/threonine kinases is involved in multiple signaling pathways including cell proliferation, differentiation, apoptosis and osteoclast ...
Ee Cheng Khor, Tamara Abel, Jennifer Tickner, Shek Man Chim, Cathy Wang, Taksum Cheng, Benjamin Ng, Pei Ying Ng, Dian Astari Teguh, Jacob Kenny, Xiaohong Yang, Honghui Chen, Keiichi I Nakayama, Keiko Nakayama, Nathan Pavlos, Ming H Zheng, Jiake Xu   +16 more
doaj   +1 more source

Pharmacological Protein Kinase C Modulators Reveal a Pro-hypertrophic Role for Novel Protein Kinase C Isoforms in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Frontiers in Pharmacology, 2021
Background: Hypertrophy of cardiomyocytes (CMs) is initially a compensatory mechanism to cardiac overload, but when prolonged, it leads to maladaptive myocardial remodeling, impairing cardiac function and causing heart failure.
Lotta Pohjolainen, Julia Easton, Reesha Solanki, Heikki Ruskoaho, Virpi Talman   +4 more
doaj   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source