Results 11 to 20 of about 95,096 (261)
Journal of Cell Science, 2004 The protein kinase C (PKC) family is represented in all eukaryotes and in Homo sapiens comprises the related PKCα through PKCι gene products ([Dempsey et al., 2000][1]). The kinase domains are closely related, as illustrated in the dendrogram, and form part of the AGC kinase superfamily ...
Parker, P J, Murray-Rust, J
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ATP competitive protein kinase C inhibitors demonstrate distinct state-dependent inhibition. [PDF]
PLoS ONE, 2011 We previously reported that some ATP competitive protein kinase C (PKC) inhibitors are either competitive or uncompetitive inhibitors with respect to substrate peptides.
Ida M Smith, Naoto Hoshi
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Cells, 2019 Background: During neuromuscular junction (NMJ) development, synapses are produced in excess. By sensing the activity-dependent release of ACh, adenosine, and neurotrophins, presynaptic receptors prompt axonal competition and loss of the unnecessary ...
Neus Garcia +6 more
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Wnt5a increases cardiac gene expressions of cultured human circulating progenitor cells via a PKC delta activation. [PDF]
PLoS ONE, 2009 Wnt signaling controls the balance between stem cell proliferation and differentiation and body patterning throughout development. Previous data demonstrated that non-canonical Wnts (Wnt5a, Wnt11) increased cardiac gene expression of circulating ...
Masamichi Koyanagi +5 more
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Molecules, 2019 Great effort is put into seeking a new and effective strategies to control insect pests. One of them is to combine natural products with chemical insecticides to increase their effectiveness.
Milena Jankowska +4 more
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Conventional PKC-alpha, novel PKC-epsilon and PKC-theta, but not atypical PKC-lambda are MARCKS kinases in intact NIH 3T3 fibroblasts. [PDF]
The Journal of biological chemistry, 1997 Phosphorylation of myristoylated alanine-rich protein kinase C substrate (MARCKS) in intact cells has been employed as an indicator for activation of protein kinase C (PKC). Specific PKC isoenzymes responsible for MARCKS phosphorylation under physiological conditions, however, remained to be identified. In our present study using stably transfected NIH
F, Uberall +7 more
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PKC signaling in glioblastoma [PDF]
Cancer Biology & Therapy, 2013 Glioblastoma Multiforme (GBM) is the most aggressive brain tumor characterized by intratumoral heterogeneity at cytopathological, genomic and transcriptional levels. Despite the efforts to develop new therapeutic strategies the median survival of GBM patients is 12-14 months.
Anália, do Carmo +3 more
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c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis
Hepatology, EarlyView., 2022 In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie +17 more
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Essential role of CD38 in platelet aggregation through the PKC- mediated internalization and activation [PDF]
BioImpactsIntroduction: CD38 is a multifunctional enzyme with a potent Ca2+ mobilizing effect, cyclic ADP-ribose (cADPR), and nicotinic acid adenine dinucleotide phosphate (NAADP).
Mazhar Mushtaq +3 more
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PKC-ζ Aggravates Doxorubicin-Induced Cardiotoxicity by Inhibiting Wnt/β-Catenin Signaling
Frontiers in Pharmacology, 2022 Doxorubicin (Dox) is a chemotherapeutic drug used to treat a wide range of cancers, but its clinical application is limited due to its cardiotoxicity.
Yan-Jun Cao +9 more
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