Results 11 to 20 of about 97,124 (258)
Protein Kinase C at the Crossroad of Mutations, Cancer, Targeted Therapy and Immune Response
Biology, 2023 The frequent PKC dysregulations observed in many tumors have made these enzymes natural targets for anticancer applications. Nevertheless, this considerable interest in the development of PKC modulators has not led to the expected therapeutic benefits ...
Angelo Aquino +3 more
doaj +1 more source
Cells, 2020 Oxidative stress is a main molecular mechanism that underlies cardiovascular diseases. A close relationship between reactive oxygen species (ROS) derived from NADPH oxidase (NOX) activity and the prostaglandin (PG) biosynthesis pathway has been described.
Javier Marqués +8 more
doaj +1 more source
ATP competitive protein kinase C inhibitors demonstrate distinct state-dependent inhibition. [PDF]
PLoS ONE, 2011 We previously reported that some ATP competitive protein kinase C (PKC) inhibitors are either competitive or uncompetitive inhibitors with respect to substrate peptides.
Ida M Smith, Naoto Hoshi
doaj +1 more source
Activators and Inhibitors of Protein Kinase C (PKC): Their Applications in Clinical Trials
Pharmaceutics, 2021 Protein kinase C (PKC), a family of phospholipid-dependent serine/threonine kinase, is classed into three subfamilies based on their structural and activation characteristics: conventional or classic PKC isozymes (cPKCs; α, βI, βII, and γ), novel or non ...
Takahito Kawano +4 more
doaj +1 more source
Cells, 2019 Background: During neuromuscular junction (NMJ) development, synapses are produced in excess. By sensing the activity-dependent release of ACh, adenosine, and neurotrophins, presynaptic receptors prompt axonal competition and loss of the unnecessary ...
Neus Garcia +6 more
doaj +1 more source
Wnt5a increases cardiac gene expressions of cultured human circulating progenitor cells via a PKC delta activation. [PDF]
PLoS ONE, 2009 Wnt signaling controls the balance between stem cell proliferation and differentiation and body patterning throughout development. Previous data demonstrated that non-canonical Wnts (Wnt5a, Wnt11) increased cardiac gene expression of circulating ...
Masamichi Koyanagi +5 more
doaj +1 more source
Molecules, 2019 Great effort is put into seeking a new and effective strategies to control insect pests. One of them is to combine natural products with chemical insecticides to increase their effectiveness.
Milena Jankowska +4 more
doaj +1 more source
Interdependence of PKC-Dependent and PKC-Independent Pathways for Presynaptic Plasticity [PDF]
Neuron, 2007 Diacylglycerol (DAG) is a prominent endogenous modulator of synaptic transmission. Recent studies proposed two apparently incompatible pathways, via protein kinase C (PKC) and via Munc13. Here we show how these two pathways converge. First, we confirm that DAG analogs indeed continue to potentiate transmission after PKC inhibition (the Munc13 pathway),
Wierda, Keimpe D. B. +4 more
openaire +5 more sources
c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis
Hepatology, EarlyView., 2022 In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie +17 more
wiley +1 more source
PKC signaling in glioblastoma [PDF]
Cancer Biology & Therapy, 2013 Glioblastoma Multiforme (GBM) is the most aggressive brain tumor characterized by intratumoral heterogeneity at cytopathological, genomic and transcriptional levels. Despite the efforts to develop new therapeutic strategies the median survival of GBM patients is 12-14 months.
Anália, do Carmo +3 more
openaire +2 more sources