Results 21 to 30 of about 97,124 (258)

Essential role of CD38 in platelet aggregation through the PKC- mediated internalization and activation [PDF]

BioImpacts
Introduction: CD38 is a multifunctional enzyme with a potent Ca2+ mobilizing effect, cyclic ADP-ribose (cADPR), and nicotinic acid adenine dinucleotide phosphate (NAADP).
Mazhar Mushtaq, Maira Mahmood, Uzma Jabbar, Uh-Hyun Kim   +3 more
doaj   +1 more source

PKC-ζ Aggravates Doxorubicin-Induced Cardiotoxicity by Inhibiting Wnt/β-Catenin Signaling

Frontiers in Pharmacology, 2022
Doxorubicin (Dox) is a chemotherapeutic drug used to treat a wide range of cancers, but its clinical application is limited due to its cardiotoxicity.
Yan-Jun Cao, Jing-Yan Li, Jing-Yan Li, Pan-Xia Wang, Zhi-Rong Lin, Wen-Jing Yu, Ji-Guo Zhang, Jing Lu, Pei-Qing Liu, Pei-Qing Liu   +9 more
doaj   +1 more source

Conventional PKC-alpha, novel PKC-epsilon and PKC-theta, but not atypical PKC-lambda are MARCKS kinases in intact NIH 3T3 fibroblasts. [PDF]

The Journal of biological chemistry, 1997
Phosphorylation of myristoylated alanine-rich protein kinase C substrate (MARCKS) in intact cells has been employed as an indicator for activation of protein kinase C (PKC). Specific PKC isoenzymes responsible for MARCKS phosphorylation under physiological conditions, however, remained to be identified. In our present study using stably transfected NIH
F, Uberall, S, Giselbrecht, K, Hellbert, F, Fresser, B, Bauer, M, Gschwendt, H H, Grunicke, G, Baier   +7 more
openaire   +2 more sources

Phosphorylation of small GTPase Rab proteins from Bombyx mori (Lepidoptera: Bombycidae)

European Journal of Entomology, 2009
Small GTPases of the Rab family act as essential regulators of vesicle transport pathways. Five Rab cDNA clones (BRab1, 7, 8, 11 and 14) from Bombyx mori were expressed in Escherichia coli as a thioredxin or glutathione sulfotransferase fusion protein ...
Tomohide UNO, Keisuke HATA, Dieu Trang LE THI, Susumu HIRAGAKI, Takuya NAKADA, Masahiko NAKAMURA, Yuichi UNO, Hiroshi YAMAGATA, Kengo KANAMARU, Makio TAKEDA, Mamoru MATSUBARA   +10 more
doaj   +1 more source

Activation of GSK3 Prevents Termination of TNF-Induced Signaling

Journal of Inflammation Research, 2021
Bastian Welz,* Rolf Bikker,* Leonie Hoffmeister, Mareike Diekmann, Martin Christmann, Korbinian Brand,* René Huber* Institute of Clinical Chemistry, Hannover Medical School, Hannover, 30625, Germany*These authors contributed equally to this ...
Welz B, Bikker R, Hoffmeister L, Diekmann M, Christmann M, Brand K, Huber R   +6 more
doaj  

Molecular expression of insulin signal transduction components in brain cells in an experimental model of Alzheimer’s disease

Анналы клинической и экспериментальной неврологии, 2019
Introduction. The risk of Alzheimers disease (AD) is increased with cerebral insulin resistance, which may be caused by the impaired function of the cerebrovascular system, and may also have a direct effect on -amyloid aggregation and Tau protein ...
Yana V. Gorina, Yuliya K. Komleva, Olga L. Lopatina, Anatolii I. Chernykh, Alla B. Salmina   +4 more
doaj   +1 more source

Activation of PKC-e counteracts maturation and apoptosis of HL-60 myeloid leukemic cells in response to TNF family members

European Journal of Histochemistry, 2009
Protein kinase C (PKC)-e, a component of the serine/threonine PKC family, has been shown to influence the survival and differentiation pathways of normal hematopoietic cells.
C. Celeghini, V. Grill, R. Voltan, E. Rimondi, D. Milani, A. Gonelli   +5 more
doaj   +3 more sources

The linoleic acid derivative DCP-LA selectively activates PKC-ɛ, possibly binding to the phosphatidylserine binding site

Journal of Lipid Research, 2006
This study examined the effect of 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA), a newly synthesized linoleic acid derivative with cyclopropane rings instead of cis-double bonds, on protein kinase C (PKC) activity.
Takeshi Kanno, Hideyuki Yamamoto, Takahiro Yaguchi, Rika Hi, Takeshi Mukasa, Hirokazu Fujikawa, Tetsu Nagata, Satoshi Yamamoto, Akito Tanaka, Tomoyuki Nishizaki   +9 more
doaj   +1 more source

A2B adenosine receptor activation and modulation by protein kinase C

iScience, 2023
Summary: Protein kinase C (PKC) isoforms regulate many important signaling pathways. Here, we report that PKC activation by phorbol 12-myristate 13-acetate (PMA) enhanced A2B adenosine receptor (AR)-mediated, but not β2-adrenergic receptor-mediated, cAMP
Zhan-Guo Gao, Ian M. Levitan, Asuka Inoue, Qiang Wei, Kenneth A. Jacobson   +4 more
doaj   +1 more source

Involvement of atypical protein kinase C in the regulation of cardiac glucose and long-chain fatty acid uptake

Frontiers in Physiology, 2012
Aim: The signaling pathways involved in the regulation of cardiac GLUT4 translocation/glucose uptake and CD36 translocation/ long-chain fatty acid uptake are not fully understood.
Daphna D.J. Habets, Joost J.F.P. Luiken, Margriet eOuwens, Will A. Coumans, Monique eVergouwe, Stine J. Maarbjerg, Michael eLeitges, Arend eBonen, Erik A. Richter, Jan eGlatz   +9 more
doaj   +1 more source