Results 51 to 60 of about 1,314,106 (300)

The dynamic switch mechanism that leads to activation of LRRK2 is embedded in the DFGψ motif in the kinase domain. [PDF]

, 2019
Leucine-rich repeat kinase 2 (LRRK2) is a large multidomain protein, and LRRK2 mutants are recognized risk factors for Parkinson's disease (PD). Although the precise mechanisms that control LRRK2 regulation and function are unclear, the importance of the
Boassa, Daniela, Ellisman, Mark H, Herberg, Friedrich W, Knape, Matthias J, Kornev, Alexandr P, Mumdey, Natascha, Schmidt, Sven H, Taylor, Susan S   +7 more
core  

Contribution of the R-Ras2 GTP-binding protein to primary breast tumorigenesis and late-stage metastatic disease [PDF]

, 2014
R-Ras2 is a transforming GTPase that shares downstream effectors with Ras subfamily proteins. However, little information exists about the function of this protein in tumorigenesis and its signalling overlap with classical Ras GTPases.
Alarcón, Balbino, Bustelo, Xosé R., Cañamero, Marta, de Alava, Enrique, Dosil, Mercedes, Larive, Ramon, Menacho Márquez, Mauricio Ariel, Moriggi, Giulia   +7 more
core   +3 more sources

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Downregulation of Mcl-1 has anti-inflammatory pro-resolution effects and enhances bacterial clearance from the lung [PDF]

, 2013
Phagocytes not only coordinate acute inflammation and host defense at mucosal sites, but also contribute to tissue damage. Respiratory infection causes a globally significant disease burden and frequently progresses to acute respiratory distress syndrome,
A Cross, A G Rossi, A Planaguma, AE Leitch, AE Leitch, AG Rossi, AL Alessandri, B Dibbert, BM Fournier, C Akgul, C D Lucas, C Haslett, C Nathan, C T Robb, CD Lucas, CN Serhan, D A Dorward, DA Dorward, DA Moulding, DA Moulding, DA Steimer, DJ Wardle, E Abraham, EE McGrath, GL Bannenberg, GS Worthen, H Liu, HG Folkesson, HM Marriott, I Dzhagalov St, I Nicoletti, J A Marwick, J Liang, JS Savill, K C Allen, K Ganeshan, KP Steinberg, L Fialkow, L Santo, M A Tait, MA Matthay, N Chiang, N Fotouhi-Ardakani, N Hirani, O Eickmeier, R Boxio, R Duffin, S Brode, S Fox, S Fox, S Michlewska, SJ Leuenroth, SL Poe, SP Garrison, T Hideshima, T Tanaka, TR Ulich, U Koedel, Y Liu   +58 more
core   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Activation of type II calcium/calmodulin-dependent protein kinase by Ca^(2+)/calmodulin is inhibited by autophosphorylation of threonine within the calmodulin-binding domain [PDF]

, 1990
It is now well established that autophosphorylation of a threonine residue located next to each calmodulin-binding domain in the subunits of type II Ca^(2+)/calmodulin-dependent protein kinase causes the kinase to remain active, although at a reduced ...
Kennedy, Mary B., Miller, Stephen G., Patton, Bruce L.   +2 more
core  

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Improved control of tuberculosis and activation of macrophages in mice lacking protein kinase R. [PDF]

PLoS ONE, 2012
Host factors that microbial pathogens exploit for their propagation are potential targets for therapeuic countermeasures. No host enzyme has been identified whose genetic absence benefits the intact mammalian host in vivo during infection with ...
Kangyun Wu, Jovanka Koo, Xiuju Jiang, Ran Chen, Stanley N Cohen, Carl Nathan   +5 more
doaj   +1 more source

Signal peptide-CUB-EGF-like repeat-containing protein 1-promoted FLT3 signaling is critical for the initiation and maintenance of MLL-rearranged acute leukemia

Haematologica, 2022
A hallmark of mixed lineage leukemia gene-rearranged (MLL-r) acute myeloid leukemia that offers an opportunity for targeted therapy is addiction to protein tyrosine kinase signaling.
Binay K. Sahoo, Yuh-Charn Lin, Cheng-Fen Tu, Chien-Chin Lin, Wei-Ju Liao, Fu-An Li, Ling-Hui Li, Kurt Yun Mou, Steve R. Roffler, Shu-Ping Wang, Chi-Tai Yeh, Chi-Yuan Yao, Hsin-An Hou, Wen-Chien Chou, Hwei-Fang Tien, Ruey-Bing Yang   +15 more
doaj   +1 more source

Investigation of the marine compound spongistatin 1 links the inhibition of PKCα translocation to nonmitotic effects of tubulin antagonism in angiogenesis [PDF]

, 2009
The aims of the study were to meet the demand of new tubulin antagonists with fewer side effects by characterizing the antiangiogenic properties of the experimental compound spongistatin 1, and to elucidate nonmitotic mechanisms by which tubulin ...
Bruns, Christiane J., Fürst, Robert, Garczarczyk, Dorota, Ischenko, Ivan, Joore, Jos, Rothmeier, Andrea S., Vollmar, Angelika M., Zahler, Stefan   +7 more
core   +1 more source