Results 11 to 20 of about 6,714,405 (407)
The Landscape of Atypical and Eukaryotic Protein Kinases
Trends in Pharmacological Sciences, 2019 Kinases are attractive anticancer targets due to their central role in the growth, survival, and therapy resistance of tumor cells. This review explores the two primary kinase classes, the eukaryotic protein kinases (ePKs) and the atypical protein ...
Georgi K Kanev +2 more
exaly +2 more sources
Metabolic Kinases Moonlighting as Protein Kinases. [PDF]
Trends in Biochemical Sciences, 2018 Protein kinases regulate every aspect of cellular activity, whereas metabolic enzymes are responsible for energy production and catabolic and anabolic processes. Emerging evidence demonstrates that some metabolic enzymes, such as pyruvate kinase M2 (PKM2), phosphoglycerate kinase 1 (PGK1), ketohexokinase (KHK) isoform A (KHK-A), hexokinase (HK), and ...
Zhimin Lu, T. Hunter
semanticscholar +3 more sources
Protein Kinases in Leukemias [PDF]
Cancers, 2021 Protein kinases (PK) make up around 2% of the human genome and their expression profile varies depending on the organ and tissue [...]
Paulo De Sepulveda, Jean-Max Pasquet
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ERK5 Inhibition Induces Autophagy-Mediated Cancer Cell Death by Activating ER Stress
Frontiers in Cell and Developmental Biology, 2021 Autophagy is a highly conserved intracellular process that preserves cellular homeostasis by mediating the lysosomal degradation of virtually any component of the cytoplasm.
Andrés Gámez-García +12 more
doaj +1 more source
Scientific Reports, 2023 Resistance to therapy remains a major obstacle in cancer management. Although treatment with hormone and CDK4/6 inhibitors is successful in luminal breast cancer, resistance to these treatments is frequent, highlighting the need for novel therapeutic ...
María Jimena Rodriguez +12 more
doaj +1 more source
Nature Communications, 2023 Autophosphorylation controls the transition between discrete functional and conformational states in protein kinases, yet the structural and molecular determinants underlying this fundamental process remain unclear.
Hipólito Nicolás Cuesta-Hernández +10 more
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Protein Kinase A in Cancer [PDF]
Cancers, 2011 In the past, many chromosomal and genetic alterations have been examined as possible causes of cancer. However, some tumors do not display a clear molecular and/or genetic signature. Therefore, other cellular processes may be involved in carcinogenesis.
CARETTA A, MUCIGNAT, CARLA
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Mapping proteome-wide targets of protein kinases in plant stress responses
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Despite the importance of phosphorylation-dependent signaling for cellular physiology, identification of kinase substrates remains very challenging.
Pengcheng Wang +13 more
semanticscholar +1 more source
Physiological Phosphorylation of Protein Kinase A at Thr-197 Is by a Protein Kinase A Kinase [PDF]
Molecular and Cellular Biology, 1998 Phosphorylation of the catalytic subunit of cyclic AMP-dependent protein kinase, or protein kinase A, on Thr-197 is required for optimal enzyme activity, and enzyme isolated from either animal sources or bacterial expression strains is found phosphorylated at this site.
Robert A. Steinberg +3 more
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Protein kinases in cardiovascular diseases
Chinese Medical Journal, 2022 . Cardiovascular disease (CVD) remains the leading cause of death worldwide. Therefore, exploring the mechanism of CVDs and critical regulatory factors is of great significance for promoting heart repair, reversing cardiac remodeling, and reducing ...
Jiawen Chen +6 more
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