Results 261 to 270 of about 1,139,517 (313)
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Journal of Gerontology, 1988
The age-related accumulation of abnormal forms of enzymes is attributable to posttranslational modification of protein structure and to a progressive loss with age of proteases that preferentially degrade the modified forms. The protein modifications include, but are not limited to: the oxidation of amino acid side chains (especially, side chains of ...
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The age-related accumulation of abnormal forms of enzymes is attributable to posttranslational modification of protein structure and to a progressive loss with age of proteases that preferentially degrade the modified forms. The protein modifications include, but are not limited to: the oxidation of amino acid side chains (especially, side chains of ...
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Chemical Protein Modification through Cysteine
ChemBioChem, 2016 The modification of proteins with non-protein entities is important for a wealth of applications, and methods for chemically modifying proteins attract considerable attention.
Annemieke Madder
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Annual Review of Biochemistry, 2004
▪ Abstract  Small ubiquitin-related modifier (SUMO) family proteins function by becoming covalently attached to other proteins as post-translational modifications. SUMO modifies many proteins that participate in diverse cellular processes, including transcriptional regulation, nuclear transport, maintenance of genome integrity, and signal transduction.
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▪ Abstract  Small ubiquitin-related modifier (SUMO) family proteins function by becoming covalently attached to other proteins as post-translational modifications. SUMO modifies many proteins that participate in diverse cellular processes, including transcriptional regulation, nuclear transport, maintenance of genome integrity, and signal transduction.
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Protein Structure and Modification of Aquaporins
2023Aquaporins (AQPs) allow water molecules and other small, neutral solutes to quickly pass through membrane. The protein structures of AQPs solved by crystallographic methods or cryo-electron microscopy technology show that AQP monomer consists of six membrane-spanning alpha-helices that form the central water-transporting pore.
Mengyao, Xiong +3 more
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1992
During aging a number of enzymes accumulate as catalytically inactive or less active forms. The age-related changes in catalytic activity are due in part to reactions of the protein with "active" oxygen species such as ozone, singlet oxygen, or with oxygen free radicals as are produced during exposure to ionizing radiation or to metal ion catalyzed ...
E R, Stadtman +4 more
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During aging a number of enzymes accumulate as catalytically inactive or less active forms. The age-related changes in catalytic activity are due in part to reactions of the protein with "active" oxygen species such as ozone, singlet oxygen, or with oxygen free radicals as are produced during exposure to ionizing radiation or to metal ion catalyzed ...
E R, Stadtman +4 more
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Quantification of protein modification by oxidants
Free Radical Biology and Medicine, 2009Proteins are major targets for oxidative damage due to their abundance and rapid rates of reaction with a wide range of radicals and excited state species, such as singlet oxygen. Exposure of proteins to these oxidants results in loss of the parent amino acid residue, formation of unstable intermediates, and the generation of stable products.
Clare L, Hawkins +2 more
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Protein Modification In Apoptosis
In recent years it has become evident that cell proliferation, differentiation and cell death (apoptosis) are controlled by an elaborate network of signalling pathways. These pathways function through receptors, protein kinases, second messengers, phosphorylated protein intermediates and factors that bind to and regulate the expression of individual ...Lavin, Martin F. +4 more
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In Vivo Chemical Modification of Proteins (Post-Translational Modification)
Annual Review of Biochemistry, 1981PERSPECTIVES AND SUMMARY . INTRODUCTION . INDIVIDUAL REACTIONS . Modifications Involving the Peptide Bonds . Modifications Involving the Carboxyland Amino-Terminals . Derivatipes of the a-corboxy/ group . DerivatiPe!J of the a-omino group .
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Modification of proteins and lipids by myeloperoxidase
1999Publisher Summary This chapter describes methods for identifying and quantifying oxidative damage to proteins, lipids, and low density lipoprotein (LDL) that has resulted from myeloperoxidase activity. It discusses general procedures for working with hypochlorous acid 1 (HOC1) and other reactive halogenating agents.
S L, Hazen +4 more
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Kinetics of Protein Modification Reactions: Analysis of Modification-Induced Protein Unfolding
Journal of Enzyme Inhibition, 1987A mathematical treatment of a two-sited, modification-induced protein unfolding model is presented, and it is shown that the dependence of the concentration of modified protein groups on reaction time is described by a linear, second-order, differential equation with nonzero right hand side.
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