Results 101 to 110 of about 3,377,935 (215)

Uncoupling the Multimerization and Nuclear Export Activities of CAV VP3 via Site-Directed Mutagenesis

, 2008
The VP3 (Apoptin) protein from the Chicken Anemia Virus has been shown to selectively kill transformed cells; an activity that is dependent on subcellular localization.
Medeiros, Adam Charles, DeConti, Derrick K.   +1 more
core   +3 more sources

Critical domains for NACC2-NTRK2 fusion protein activation.

PLoS ONE
Neurotrophic receptor tyrosine kinases (NTRKs) belong to the receptor tyrosine kinase (RTK) family. NTRKs are responsible for the activation of multiple downstream signaling pathways that regulate cell growth, proliferation, differentiation, and ...
Wei Yang, April N Meyer, Zian Jiang, Xuan Jiang, Daniel J Donoghue   +4 more
doaj   +1 more source

Multimerization of HIV proteins.

, 2014
*Bolded residues are known multimerization inhibitors.
Ray Matti (543812), Monika Chakarova (543806), Dorothea Q. Maza (543813), Karlyn M. Dobritch (543808), Sandeep Deverasetty (350919), Sarah Songao (543820), Christy L. Strong (543799), Noura Rezapour (543818), Rma Kumra (571397), Austin Pomerantz (543816), Frederick A. Brown (543804), Izua J. Alaniz (543800), David I. Dorsky (571401), David P. Sargeant (112785), Sabyasachy Mistry (543814), Horacio P. Guerra (543809), Alexandria Bartlett (571396), Nemanja Novakovic (543815), Kelvy S. Levitt (571398), Sandy Yousif (543822), Steven B. Brooks (543803), Roxanne P. David (543807), Kiran R. Mathew (543811), Sean L. Tuggle (543821), Viraj R. Rathnayake (571400), Flaviona Bufi (543805), Nicholas R. Brandon (543802), Martin R. Schiller (112812), Michael W. Hedden (543798), Timothy F. Rafalski (543817), Josue Portillo (571399)   +30 more
core   +1 more source

A quantitative IN subunit exchange assay specifically illustrates multimerization defect of IN dimeric interface mutants.

, 2013
(A) Mechanics of the subunit exchange assay for quantifying HIV-1 IN multimerization. Mutant IN was expressed with a 6x Histidine tag, while WT IN was expressed with a GST tag.
Wannes Thys (307258), Jonas Demeulemeester (180282), Zeger Debyser (20227), Laith Q. Al-Mawsawi (307260), Erik Serrao (307256), Frauke Christ (180292), Nouri Neamati (275633)   +6 more
core   +1 more source

Intracellular interactions between APOBEC3G, RNA, and HIV-1 Gag: APOBEC3G multimerization is dependent on its association with RNA

Retrovirology, 2009
Background Host restriction factor APOBEC3G (A3G) blocks human immunodeficiency virus type 1 (HIV-1) replication by G-to-A hypermutation, and by inhibiting DNA synthesis and provirus formation.
Friew Yeshitila N, Boyko Vitaly, Hu Wei-Shau, Pathak Vinay K   +3 more
doaj   +1 more source

Peroxisomal membrane proteins insert into the endoplasmic reticulum [PDF]

, 2010
We show that a comprehensive set of 16 peroxisomal membrane proteins (PMPs) encompassing all types of membrane topologies first target to the endoplasmic reticulum (ER) in Saccharomyces cerevisiae.
Sub Cellular Protein Chemistry, van der Zand, A., Tabak, H.F., Braakman, L.J., Cellular Protein Chemistry   +4 more
core   +1 more source

The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir

mBio
Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are investigational antiretroviral agents that potently impair virion maturation by inducing hyper-multimerization of IN and inhibiting its interaction with viral genomic RNA. The pyrrolopyridine-based
Tung Dinh, Zahira Tber, Juan S. Rey, Seema Mengshetti, Arun S. Annamalai, Reed Haney, Lorenzo Briganti, Franck Amblard, James R. Fuchs, Peter Cherepanov, Kyungjin Kim, Raymond F. Schinazi, Juan R. Perilla, Baek Kim, Mamuka Kvaratskhelia   +14 more
doaj   +1 more source

The hexamer structure of Rift Valley fever virus nucleoprotein suggests a mechanism for its assembly into ribonucleoprotein complexes.

PLoS Pathogens, 2011
Rift Valley fever virus (RVFV), a Phlebovirus with a genome consisting of three single-stranded RNA segments, is spread by infected mosquitoes and causes large viral outbreaks in Africa.
François Ferron, Zongli Li, Eric I Danek, Dahai Luo, Yeehwa Wong, Bruno Coutard, Violaine Lantez, Rémi Charrel, Bruno Canard, Thomas Walz, Julien Lescar   +10 more
doaj   +1 more source

A disulfide-bond A oxidoreductase-like protein (DsbA-L) regulates adiponectin multimerization

, 2008
Impairments in adiponectin multimerization lead to defects in adiponectin secretion and function and are associated with diabetes, yet the underlying mechanisms remain largely unknown.
Wetzel, MD, Xin, X, Dong, LQ, Liu, F, Lam, KSL, Liu, M, Xiang, R, Xu, A, Zhou, L, Zhang, J   +9 more
core   +1 more source

Determining biophysical protein stability in lysates by a fast proteolysis assay, FASTpp. [PDF]

, 2012
The biophysical stability is an important parameter for protein activity both in vivo and in vitro. Here we propose a method to analyse thermal melting of protein domains in lysates: Fast parallel proteolysis (FASTpp).
Rüdiger, Stefan G. D., Stefan G D Rüdiger, Maurice, Madelon M., David P Minde, Sub Cellular Protein Chemistry, Stefan G. D. Rüdiger, Madelon M Maurice, Minde, David P., Cellular Protein Chemistry, David P. Minde, Madelon M. Maurice   +10 more
core   +3 more sources