Results 81 to 90 of about 3,377,935 (215)
Order Statistics Theory of Unfolding of Multimeric Proteins [PDF]
Biophysical Journal, 2010 Dynamic force spectroscopy has become indispensable for the exploration of the mechanical properties of proteins. In force-ramp experiments, performed by utilizing a time-dependent pulling force, the peak forces for unfolding transitions in a multimeric protein (D)(N) are used to map the free energy landscape for unfolding for a protein domain D.
Zhmurov, A., Dima, R.I., Barsegov, V.
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VIEW, EarlyView.Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
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Journal of Integrative Plant Biology, EarlyView.This review decodes the grammar of plant cis‐regulatory elements, revealing that their function emerges from sequence, chromatin accessibility, 3D topology, and cell type context. It highlights how single‐cell omics, CRISPR dissection, and AI‐driven design converge to enable predictive engineering and crop improvement. ABSTRACT Cis‐regulatory elements (
Libin Zhang, Maoteng Li
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Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, Volume 600, Issue 17, Page 2526-2546, September 2026.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
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A chemical approach to the construction of multimeric protein assemblies [PDF]
Structure, 1995 Chemical and enzymatic ligation approaches provide a general route to the synthesis of proteins whose primary structure is not restricted to the genetic code. Thus, one can replace key residues in a protein with unnatural amino acids whose chemical or structural properties can be tailored to probe specific aspects of function. In addition, isotopically
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The Alzheimer's disease risk gene SORL1 is a regulator of excitatory neuronal function
Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.Abstract INTRODUCTION Synaptic dysfunction is an early feature of Alzheimer's disease (AD) and proper localization of proteins involved in pre‐ and post‐synaptic composition is dependent on endosomal recycling and trafficking, cellular processes involving the AD risk gene sortilin‐related receptor 1 (SORL1). METHODS We examined SORL1's role in synaptic
C. Andrew Williams +6 more
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Protein-RNA interactions: a structural analysis [PDF]
, 2001 A detailed computational analysis of 32 protein-RNA complexes is presented. A number of physical and chemical properties of the intermolecular interfaces are calculated and compared with those observed in protein-double-stranded DNA and protein-single ...
Daley, DT +9 more
core
HIV-1 Rev multimerization: mechanism and insights
, 2013 To export intron-containing viral mRNAs that encode the structural components of new viral particles from the nucleus to the cytoplasm, HIV-1 uses the cellular CRM1 export pathway that is exploited by the viral Rev protein.
Daelemans, Dirk, Vercruysse, Thomas
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Analysis of multimerization of the SARS coronavirus nucleocapsid protein
Biochemical and Biophysical Research Communications, 2004 Severe Acute Respiratory Syndrome (SARS), an emerging disease characterized by atypical pneumonia, has recently been attributed to a novel coronavirus. The genome of SARS Coronavirus (SARS-CoV) has recently been sequenced, and a number of genes identified, including that of the nucleocapsid protein (N).
He, R +13 more
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Arabidopsis AUGMIN8 Contains Two Independent Microtubule Association Domains
Cytoskeleton, Volume 83, Issue 9, Page 752-767, September 2026.ABSTRACT Plant cells create a plasma membrane‐associated network of microtubules that are nucleated by γ‐tubulin ring complexes primarily through microtubule‐dependent microtubule nucleation (MDMN). This dynamic array organizes into specific patterns in response to developmental and environmental cues to influence primary cell wall construction.
Naveen K. Chana +2 more
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