Results 81 to 90 of about 30,399 (190)

Hierarchically Engineered Multi‐Enzyme Nanoreactors for in vitro Drug Biosynthesis and Pathway Transplantation Into Cells

Advanced Materials, Volume 38, Issue 34, 17 June 2026.
A hierarchically structured metal–organic framework (eMIL) is shown to host the complete six‐enzyme biosynthesis pathway for the anti‐cancer pigment violacein, reshaping reaction dynamics and multiplying in vitro yields. eMIL nanoreactors deliver this reconstituted bacterial multi‐protein system into mammalian cells, where cell‐derived substrates and ...
Ainur Sharip, Somayah S. Qutub, Manar M. Farooqui, Walaa Baslyman, Nida Khalfay, Lukman O. Alimi, Patricia Lopez Sanchez, Lingyun Zhao, Milena Chernyshevskaia, Giovanni Colombo, Niveen M. Khashab, Stefan T. Arold, Raik Grünberg   +12 more
wiley   +1 more source

Antigenic Properties of N Protein of Hantavirus

Viruses, 2014
Hantavirus causes two important rodent-borne viral zoonoses, hemorrhagic fever with renal syndrome (HFRS) in Eurasia and hantavirus pulmonary syndrome (HPS) in North and South America.
Kumiko Yoshimatsu, Jiro Arikawa
doaj   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, Volume 13, Issue 35, 24 June 2026.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

The Emerging Parkinson's Disease Oxylipin‐Ome

Advanced Science, Volume 13, Issue 33, 15 June 2026.
ABSTRACT Parkinson Disease (PD) is increasingly considered a proteinopathy and lipidopathy. This proteinopathy+lipidopathy paradigm has been further refined to a fatty acid (FA)‐opathy, centering dysregulated FA metabolism as fundamental in PD lipid dysfunction.
Julia C. Kelliher, Saranna Fanning
wiley   +1 more source

High‐Yield Production and Cost‐Effective Purification of an Alkali‐Resistant Hexameric Protein A Variant for Antibody Affinity Chromatography

Biotechnology Journal, Volume 21, Issue 6, June 2026.
Graphical Abstract and Lay Summary We present a scalable method for producing the antibody‐binding ligand Z6AlkC, a six‐repeat, alkali‐resistant Protein A–derived Z domain with a terminal cysteine. The ligand was produced at high yield via extracellular secretion in bioreactors and subsequently purified by high‐productivity ultradiafiltration with low ...
Carolina Mota Natal, Claudia Lacombe, Alexander Zollner, Catarina Domingos, José Mendes, André Nascimento, Ana Margarida Gonçalves Carvalho Dias, Arménio Jorge Moura Barbosa, Cristina Peixoto, Birgit Wiltschi, Alois Jungbauer, Ana Cecília Afonso Roque   +11 more
wiley   +1 more source

A working model for CCN3 C‐terminal domain‐mediated transcriptional modulation of the plasminogen activation system

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Plasminogen is a circulating zymogen that is converted into active plasmin by plasminogen activators such as tissue plasminogen activator (tPA) and urokinase‐type PA (uPA). This conversion is regulated by plasminogen activator inhibitors (PAI‐1, PAI‐2) and by inhibitors of plasmin itself, maintaining a fine balance between activation and inhibition of ...
Bernard Perbal
wiley   +1 more source

Intracellular interactions between APOBEC3G, RNA, and HIV-1 Gag: APOBEC3G multimerization is dependent on its association with RNA

Retrovirology, 2009
Background Host restriction factor APOBEC3G (A3G) blocks human immunodeficiency virus type 1 (HIV-1) replication by G-to-A hypermutation, and by inhibiting DNA synthesis and provirus formation.
Friew Yeshitila N, Boyko Vitaly, Hu Wei-Shau, Pathak Vinay K   +3 more
doaj   +1 more source

Multiplexed Retinoic Acid Signal Reporters for In Vivo and In Vitro Use

genesis, Volume 64, Issue 3, June 2026.
ABSTRACT Here we describe the optimisation of a modular, generally applicable and rapid method to make multimerised signaling‐molecule reporters for detecting different retinoic acid concentrations. The technical plasmid design allows for the easy exchange of reporters, promoters, signal‐responsive elements as well as for the multimerization of entire ...
Craig Smith, Bianca Black, Ric Broadhurst, Stacey Parbhu, Peter L. Pfeffer   +4 more
wiley   +1 more source

The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir

mBio
Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are investigational antiretroviral agents that potently impair virion maturation by inducing hyper-multimerization of IN and inhibiting its interaction with viral genomic RNA. The pyrrolopyridine-based
Tung Dinh, Zahira Tber, Juan S. Rey, Seema Mengshetti, Arun S. Annamalai, Reed Haney, Lorenzo Briganti, Franck Amblard, James R. Fuchs, Peter Cherepanov, Kyungjin Kim, Raymond F. Schinazi, Juan R. Perilla, Baek Kim, Mamuka Kvaratskhelia   +14 more
doaj   +1 more source

The hexamer structure of Rift Valley fever virus nucleoprotein suggests a mechanism for its assembly into ribonucleoprotein complexes.

PLoS Pathogens, 2011
Rift Valley fever virus (RVFV), a Phlebovirus with a genome consisting of three single-stranded RNA segments, is spread by infected mosquitoes and causes large viral outbreaks in Africa.
François Ferron, Zongli Li, Eric I Danek, Dahai Luo, Yeehwa Wong, Bruno Coutard, Violaine Lantez, Rémi Charrel, Bruno Canard, Thomas Walz, Julien Lescar   +10 more
doaj   +1 more source