Results 71 to 80 of about 3,377,935 (215)

Characterization of Hantavirus N Protein Intracellular Dynamics and Localization

Viruses, 2022
Hantaviruses are enveloped viruses that possess a tri-segmented, negative-sense RNA genome. The viral S-segment encodes the multifunctional nucleocapsid protein (N), which is involved in genome packaging, intracellular protein transport, immunoregulation,
Robert-William Welke, Hannah Sabeth Sperber, Ronny Bergmann, Amit Koikkarah, Laura Menke, Christian Sieben, Detlev H. Krüger, Salvatore Chiantia, Andreas Herrmann, Roland Schwarzer   +9 more
doaj   +1 more source

RNA‐centric world of retroviruses: unravelling the molecular strategies of genomic RNA packaging

Biological Reviews, EarlyView.
ABSTRACT Retroviruses constitute a unique group of RNA viruses that have profoundly influenced both evolutionary trajectories and biomedical research. Their ability to reverse transcribe and integrate into host genomes has shaped genomic architecture across species and contributed to our understanding of oncogenes, gene regulation, and RNA biology ...
Mohammad Abdullah Jehad, Suresha G. Prabhu, Lizna M. Ali, Vineeta N. Pillai, Farah Mustafa, Tahir A. Rizvi   +5 more
wiley   +1 more source

Recombinant Monoclonal Antibodies for Detecting the Tubulin Post‐Translational Modifications Glutamylation and Lysine‐40 Acetylation

Cytoskeleton, EarlyView.
ABSTRACT Post‐translational modifications (PTMs) to tubulin subunits in microtubule filaments are thought to comprise a component of the tubulin code that specifies microtubule functions in cell physiology and animal development. Acetylation of Lysine‐40 (K40) on α‐tubulin (αTub‐K40ac) and glutamylation of both α‐ and β‐tubulin are two tubulin PTMs of ...
Lynne Blasius, Ezekiel C. Thomas, Erik H. Collet, Erin Jenson, Chad G. Pearson, Ryoma Ohi, Kristen J. Verhey   +6 more
wiley   +1 more source

Mechanisms for the Evolution of Protein Multimerization and Allostery [PDF]

Understanding how protein structure and function are determined by amino acid sequence is fundamental to biochemistry. Evolutionary biochemistry extends the classic sequence–structure–function paradigm by incorporating evolutionary history to understand ...
Cortez, Carlos
core   +1 more source

ASPPs multimerize protein phosphatase 1

PLOS Genetics
Abstract Protein Phosphatase 1 (PP1) activity is thought to be spatiotemporally defined by hundreds of different regulatory subunits, but their mechanisms of action are largely unknown. The Ankyrin repeat, SH3-domain, and Proline-rich region containing Proteins (ASPPs) bind and localize PP1 to cell-cell junctions ...
Derek T. Wei, Kayleigh N. Morrison, Gwendolyn M. Beacham, Erika Beyrent, Ying Zhang, Laurence Florens, Gunther Hollopeter   +6 more
openaire   +5 more sources

Protocol for Reconstituting Adaptor‐Mediated Activation of Full‐Length Kinesin‐1

Cytoskeleton, EarlyView.
ABSTRACT Kinesin‐1 is a member of the kinesin superfamily that plays an essential role in intracellular cargo transport. In the absence of cargo, Kinesin‐1 exhibits low motor activity due to autoinhibition. Multiple studies have demonstrated that adaptor proteins, which link cargos to Kinesin‐1, can activate Kinesin‐1 by releasing the autoinhibition ...
Haruka Masumoto, Kyoko Chiba
wiley   +1 more source

Structural Insights into RNA Dimerization: Motifs, Interfaces and Functions

Molecules, 2020
In comparison with the pervasive use of protein dimers and multimers in all domains of life, functional RNA oligomers have so far rarely been observed in nature.
Charles Bou-Nader, Jinwei Zhang
doaj   +1 more source

The HIVToolbox 2 web system integrates sequence, structure, function and mutation analysis. [PDF]

PLoS ONE, 2014
There is enormous interest in studying HIV pathogenesis for improving the treatment of patients with HIV infection. HIV infection has become one of the best-studied systems for understanding how a virus can hijack a cell. To help facilitate discovery, we
David P Sargeant, Sandeep Deverasetty, Christy L Strong, Izua J Alaniz, Alexandria Bartlett, Nicholas R Brandon, Steven B Brooks, Frederick A Brown, Flaviona Bufi, Monika Chakarova, Roxanne P David, Karlyn M Dobritch, Horacio P Guerra, Michael W Hedden, Rma Kumra, Kelvy S Levitt, Kiran R Mathew, Ray Matti, Dorothea Q Maza, Sabyasachy Mistry, Nemanja Novakovic, Austin Pomerantz, Josue Portillo, Timothy F Rafalski, Viraj R Rathnayake, Noura Rezapour, Sarah Songao, Sean L Tuggle, Sandy Yousif, David I Dorsky, Martin R Schiller   +30 more
doaj   +1 more source

Mosaic activation of the zebrafish hsp70l heat shock promoter: Implications for interpreting transgenes

Developmental Dynamics, EarlyView.
Abstract Background The promoters and enhancers of heat shock genes, such as the 1.5‐kb promoter of the zebrafish hsp70l gene, are valuable tools for temporal activation of transgenes. It has been widely purported that heat shock treatments result in ubiquitous expression of hsp70l‐driven transgenes.
Jong‐Su Park, Xiangyun Wei
wiley   +1 more source

Pretargeted Imaging with Gallium-68—Improving the Binding Capability by Increasing the Number of Tetrazine Motifs

Pharmaceuticals, 2018
The inverse electron-demand Diels-Alder reaction between 1,2,4,5-tetrazine (Tz) and trans-cyclooct-2-ene (TCO) has gained increasing attraction among extensive studies on click chemistry due to its exceptionally fast reaction kinetics and high ...
Dominik Summer, Sonja Mayr, Milos Petrik, Christine Rangger, Katia Schoeler, Lisa Vieider, Barbara Matuszczak, Clemens Decristoforo   +7 more
doaj   +1 more source