Results 91 to 100 of about 992,662 (310)
Shipin gongye ke-jiThis study aimed to optimize a new efficient and safe thawing method for frozen beef, and maintain its sensory and edible quality. The frozen beef was used for the test material, the traditional low-temperature thawing (4 ℃, RH 65%~73%) treatment was set
Huixin FU +4 more
doaj +1 more source
Forced Degradation Testing as Complementary Tool for Biosimilarity Assessment [PDF]
, 2019 Oxidation of monoclonal antibodies (mAbs) can impact their efficacy and may therefore represent critical quality attributes (CQA) that require evaluation.
Dyck, Yan Felix Karl +6 more
core +1 more source
Antioxidants and protein oxidation. [PDF]
Free radical research, 2000 Proteins are susceptible to oxidation by reactive oxygen species, where the type of damage induced is characteristic of the denaturing species. The induction of protein carbonyls is a widely applied biomarker, arising from primary oxidative insult. However, when applied to complex biological and pathological conditions it can be subject to interference
openaire +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
A sensitive and specific ELISA detects methionine sulfoxide-containing apolipoprotein A-I in HDL*
Journal of Lipid Research, 2009 Oxidized HDL has been proposed to play a key role in atherogenesis. A wide range of reactive intermediates oxidizes methionine residues to methionine sulfoxide (MetO) in apolipoprotein A-I (apoA-I), the major HDL protein.
Xiao Suo Wang +5 more
doaj +1 more source
Iron redox pathway revealed in ferritin via electron transfer analysis. [PDF]
, 2020 Ferritin protein is involved in biological tissues in the storage and management of iron - an essential micro-nutrient in the majority of living systems. While there are extensive studies on iron-loaded ferritin, its functionality in iron delivery is not
Bandaru, Prabhakar R +3 more
core
How are proteins reduced in the endoplasmic reticulum? [PDF]
, 2018 The reversal of thiol oxidation in proteins within the endoplasmic reticulum (ER) is crucial for protein folding, degradation, chaperone function, and the ER stress response. Our understanding of this process is generally poor but progress has been made.
Bulleid, Neil +2 more
core +2 more sources
Electrospray Photochemical Oxidation of Proteins
Journal of the American Society for Mass Spectrometry, 2019 Photooxidation of peptides and proteins by pulsed ultraviolet laser irradiation of an electrospray in the ion source of a mass spectrometer was demonstrated. A 193-nm excimer laser at 1.5-mJ pulse energy was focused with a cylindrical lens at the exit of a nanoelectrospray capillary and ions were sampled into a quadrupole time-of-flight mass ...
Remilekun O, Lawal +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Electroactive cytochromeP450BM3 cast polyion films on graphite electrodes [PDF]
, 2006 Films of electrochemically active cytochrome P450BM3 were constructed on graphite electrodes using alternate assembly with polyethyleneimin(PEI). The original layer-by-layer adsorption method was slightly modified here to form so-called “cast polyion ...
Basséguy, Régine +2 more
core +3 more sources