Results 81 to 90 of about 4,860,198 (303)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Effect of Freezing Methods on the Physical and Chemical Properties and Protein Oxidation of Porcine Liver

Shipin gongye ke-ji
To address the quality deterioration of porcine liver during frozen storage, the impacts of different freezing methods on porcine liver were investigated, including −20 ℃ conventional air freezing (CAF), −80 ℃ refrigerator cryogenic freezing (RCF) and ...
Ge ZHANG, Juan YOU, Hong YANG
doaj   +1 more source

Antioxidants and protein oxidation. [PDF]

Free radical research, 2000
Proteins are susceptible to oxidation by reactive oxygen species, where the type of damage induced is characteristic of the denaturing species. The induction of protein carbonyls is a widely applied biomarker, arising from primary oxidative insult. However, when applied to complex biological and pathological conditions it can be subject to interference
openaire   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Effects of Variable Temperature and High Humidity Combined with Low Voltage Electrostatic Field Treatment on Thawing Effect and Protein Oxidation of Beef

Shipin gongye ke-ji
This study aimed to optimize a new efficient and safe thawing method for frozen beef, and maintain its sensory and edible quality. The frozen beef was used for the test material, the traditional low-temperature thawing (4 ℃, RH 65%~73%) treatment was set
Huixin FU, Ting ZHANG, Xue QIAO, Yajie QIAO, Xintao MENG   +4 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Modifying the Dietary Carbohydrate-to-Protein Ratio Alters the Postprandial Macronutrient Oxidation Pattern in Liver of AMPK-Deficient Mice

, 2017
International audienceBackground: Hepatic AMP-activated kinase (AMPK) activity is sensitive to the dietary carbohydrate-to-protein ratio. However, the role of AMPK in metabolic adaptations to variations in dietary macronutrients remains poorly understood.
Even, Patrick,, Claire Gaudichon, Benoit Viollet, Tristan Chalvon-Demersay, Tomé, Daniel, D., Gaudichon, Claire,, Chaumontet, Catherine, Viollet, Benoit, Patrick C Even, Marc Foretz, Chaumontet, Catherine, C., Dalila Azzout-Marniche, Piedcoq, Julien,, Tomé, Daniel,, Gaudichon, Claire, C., Chalvon-Demersay, Tristan, Azzout-Marniche, Dalila,, Azzout-Marniche, Dalila, D., Foretz, Marc, Catherine Chaumontet, Even, Patrick, C., Daniel Tomé, Piedcoq, Julien, J., Julien Piedcoq   +23 more
core   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Protein Oxidation in Metabolic Syndrome

Clinical and Investigative Medicine, 2013
Purpose Oxidative stress plays a pivotal role in the pathogenesis of the metabolic syndrome and in the progression of its complications. Carbonylated proteins are a stable marker of severe oxidative stress because damage to the protein structure is irreversible and may cause an inhibition of their enzymatic activity or an increased susceptibility to ...
Hopps, Eugenia, Caimi, Gregorio
openaire   +3 more sources

The respiratory arsenite oxidase: structure and the role of residues surrounding the Rieske cluster [PDF]

, 2013
The arsenite oxidase (Aio) from the facultative autotrophic Alphaproteobacterium Rhizobium sp. NT-26 is a bioenergetic enzyme involved in the oxidation of arsenite to arsenate.
Muse Oke (452182), Nicole Bruselat (452184), Oke Muse, Konstantinos Thalassinos (452186), Joanne M Santini, Warelow, TP, Santini, JM, Leimkühler, Silke (Prof. Dr.), Thalassinos Konstantinos, Dahl Jan U., James H. Naismith (198956), Bruselat, Nicole, Kappler, U, Sivalingam Ganesh N., Kappler, Ulrike, Dahl, JU, Muse Oke, Barbara Schoepp-Cothenet (95047), Santini, Joanne M., Barbara Schoepp-Cothenet, Ganesh N Sivalingam, Thomas P. Warelow (452181), Ganesh N. Sivalingam (452185), Bruselat Nicole, Oke, M, James H Naismith, Leimkuehler, Silke, Thalassinos, K, Jan U Dahl, Oke, Muse, Schoepp-Cothenet, B, Thomas P Warelow, Silke Leimkühler (126058), Naismith James H., Dahl, Jan U., Konstantinos Thalassinos, Sivalingam, Ganesh N., Jan U. Dahl (452183), Kappler Ulrike, Leimkühler, S, Ulrike Kappler, Naismith, JH, Santini Joanne M., Nicole Bruselat, Silke Leimkühler, Warelow, Thomas P., Ulrike Kappler (129280), Warelow Thomas P., Sivalingam, GN, Schoepp-Cothenet, Barbara, Naismith, James H., Joanne M. Santini (452187), Thalassinos, Konstantinos, Bruselat, N, Leimkühler, Silke, Schoepp-Cothenet Barbara, Leimkühler Silke   +56 more
core   +1 more source