Results 61 to 70 of about 992,662 (310)

Iron-induced kidney cell damage: insights into molecular mechanisms and potential diagnostic significance of urinary FTL

Frontiers in Molecular Biosciences
Background: Iron overload can lead to organ and cell injuries. Although the mechanisms of iron-induced cell damage have been extensively studied using various cells, little is known about these processes in kidney cells.Methods: In this study, we first ...
Soraya Punchai, Nachayada Chaiyagot, Nadthanicha Artkaew, Nadthanicha Artkaew, Apinya Jusakul, Apinya Jusakul, Ubon Cha’on, Ubon Cha’on, Raynoo Thanan, Raynoo Thanan, Kulthida Vaeteewoottacharn, Kulthida Vaeteewoottacharn, Worachart Lert-Itthiporn, Worachart Lert-Itthiporn, Worachart Lert-Itthiporn   +14 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Influence of Purple Onion Pulp Addition Level on Oxidative, Microbial, and Sensory Characteristics of Refrigerated Beef Patties

Foods
Pre-treated beef patties (BPs) face storage instability due to lipid/protein oxidation, microbial spoilage, and quality loss. Purple onion pulp (OP), a bioactive-rich product, offers potential as a natural preservative.
Jiaxin Wei, Fujuan Zhang, Li Yang, Cuntang Wang   +3 more
doaj   +1 more source

Redox modulation of thimet oligopeptidase activity by hydrogen peroxide

FEBS Open Bio, 2017
Thimet oligopeptidase (EC 3.4.24.15, TOP) is a cytosolic mammalian zinc protease that can process a diversity of bioactive peptides. TOP has been pointed out as one of the main postproteasomal enzymes that process peptide antigens in the MHC class I ...
Marcelo Y. Icimoto, Juliana C. Ferreira, César H. Yokomizo, Larissa V. Bim, Alyne Marem, Joyce M. Gilio, Vitor Oliveira, Iseli L. Nantes   +7 more
doaj   +1 more source

Mesoscopic sponge-like topology engineered onto polypropylene promotes retention of bound protein: [PDF]

, 2006
The interaction between biopolymers and plastic surfaces defines an area of much interest. In this study, the oxidative activation, surface engineering and protein binding ability of polypropylene derivatives were examined.
Ozturk, Gozde Ipek, Taralp, Alpay, Öztürk, Gözde İpek   +2 more
core  

N-terminal and C-terminal domains of calmodulin mediate FADD and TRADD interaction [PDF]

, 2015
FADD (Fas–associated death domain) and TRADD (Tumor Necrosis Factor Receptor 1-associated death domain) proteins are important regulators of cell fate in mammalian cells. They are both involved in death receptors mediated signaling pathways and have been
Balog, Edward M., Castellani, Loriana, Crielesi, Roberta, LALLI, CRISTIANA, MARSILIO, Sonia, Papoff, Giuliana, Ruberti, Giovina, Trivieri, Nadia   +7 more
core   +4 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Growth of Rhodococcus sp. strain BCP1 on gaseous n-alkanes: New metabolic insights and transcriptional analysis of two soluble di-iron monooxygenase genes [PDF]

, 2015
Rhodococcus sp. strain BCP1 was initially isolated for its ability to grow on gaseous n-alkanes, which act as inducers for the co-metabolic degradation of low-chlorinated compounds.
Cappelletti M., Fedi S., Frascari D., Milazzo G., Presentato A., Turner R. J., Zannoni D.   +6 more
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Protective effects of curcumin on laying hens fed soybean meal with heat-induced protein oxidation

Italian Journal of Animal Science, 2021
This study was performed to investigate the effects of curcumin supplementation on intestinal barrier function, serum biochemical index, amino acid profile, and mRNA expression of nutrient transporters in laying hens fed soybean meal with heat-induced ...
Yunfeng Gu, Yueping Chen, Rui Jin, Chao Wang, Chao Wen, Yanmin Zhou   +5 more
doaj   +1 more source