Results 101 to 110 of about 1,444,803 (306)

Repo-Man coordinates chromosomal reorganization with nuclear envelope reassembly during mitotic exit [PDF]

, 2011
This article is available open access under a Creative Commons license (http://creativecommons.org/licenses/by/3.0/). Copyright @ 2011 Elsevier Inc.Repo-Man targets protein phosphatase 1 γ (PP1γ) to chromatin at anaphase onset and regulates chromosome ...
Vagnarelli, Paola, Rappsilber, Juri, Susana Ribeiro, David A. Kelly, Ribeiro, S, Sanchez-Pulido, Luis, Luis Sanchez-Pulido, Ponting, CP, Verheyen, Toon, de Lima Alves, F, Sennels, L, de Lima Alves, Flavia, Ponting, Chris P.; id_orcid, Ponting, Chris P., William C. Earnshaw, Earnshaw, William C., Vagnarelli, P, Sennels, Lau, Kelly, David A., Verheyen, T, Chris P. Ponting, Sanchez-Pulido, L, Ribeiro, Susana, Paola Vagnarelli, Juri Rappsilber, Alves, Flavia de Lima, Kelly, DA, Rappsilber, J, Earnshaw, WC, Lau Sennels, Flavia de Lima Alves, Toon Verheyen   +31 more
core   +1 more source

Memantine Attenuates Alzheimer's Disease-Like Pathology and Cognitive Impairment.

PLoS ONE, 2015
Deficiency of protein phosphatase-2A is a key event in Alzheimer's disease. An endogenous inhibitor of protein phosphatase-2A, inhibitor-1, I1PP2A, which inhibits the phosphatase activity by interacting with its catalytic subunit protein phosphatase-2Ac,
Xiaochuan Wang, Julie Blanchard, Inge Grundke-Iqbal, Khalid Iqbal   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The role of AMPK and CREB-1 in the regulation of mitochondrial biogenesis during muscle differentiation [PDF]

, 2007
The aim of the study was to identify main regulators of mitochondrial biogenesis in a skeletal muscle differentiation model. To investigate candidate factors we used the cytochrome c promoter as a representative promoter since cytochrome c levels ...
Frankó, András
core  

SARP, a new alternatively spliced protein phosphatase 1 and DNA interacting protein [PDF]

, 2006
PP1 (protein phosphatase 1) is a ubiquitously expressed serine/threonine-specific protein phosphatase whose activity towards different substrates appears to be mediated via binding to specific proteins that play critical regulatory and targeting roles ...
Oxenham, Senga K., Cohen, Patricia T. W., da Cruz E Silva, Edgar F., Browne, Gareth J., da Cruz E Silva, Odete A.B., Cohen, Patricia T.W., da Cruz E. Silva, Edgar F., Helps, Nicholas R., da Cruz E. Silva, Odete A. B., Fardilha, Margarida, Wu, Wenjuan   +10 more
core   +1 more source

A CDCA2–MYC positive feedback loop controls cancer cells survival [PDF]

Open Biology
Cellular myelocytomatosis oncogene (MYC) transcription factors are encoded by a family of genes that include the prototype member MYC, MYCN and MYCL, and most human cancers display expression alterations of MYC genes. MYC is regulated at multiple levels,
Konstantinos Stamatiou, Lorena Ligammari, Malki Bothota, Antonia Tsavou, Ezgi Gokhan, Ylenia Cicirò, Mariano F. Zacarías-Fluck, Laura Soucek, Arturo Sala, Paola Vagnarelli   +9 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis [PDF]

, 2012
Peer ...
Welch, A, Robert Judson (279511), Mirela Delibegović, Louise Grant (181930), Grant Louise, Emma K Lees, Judson, R, Andy Welch (181948), Göransson, Olga, Goransson, O, Barbara B Kahn, George D. Mcilroy (181939), Carl Owen (181917), Mcilroy George D., Kendra K. Bence (149032), Olga Göransson, Mody Nimesh, Benjamin G. Neel (162598), Lees, Emma K, Kahn Barbara B., Louise Grant, Nimesh Mody (181963), Bence, Kendra K., Neel Benjamin G., Bence, KK, Grant, L, Owen, C, Mody, Nimesh, Mcilroy, George D, Neel, BG, Owen, Carl, Welch Andy, Olga Göransson (181943), Agouni, Abdelali, Neel, Benjamin G, Abdelali Agouni, Czopek Alicja, Kahn, Barbara B, Neel, Benjamin G., Bence Kendra K., Agouni, A, Lees, Emma K., McIlroy, George, Bence, Kendra K, Abdelali Agouni (181926), Nimesh Mody, Göransson Olga, Lund University., Judson, Robert, Czopek, Alicja, Mody, N, Czopek, A, Kendra K Bence, Mirela Delibegović (181968), Andy Welch, George D Mcilroy, Alicja Czopek (181921), Grant, Louise, Lees, EK, Benjamin G. Neel, Barbara B. Kahn, Delibegovic, Mirela, Barbara B. Kahn (181955), Agouni Abdelali, Kahn, Barbara B., Judson Robert, Göransson, Olga,, Mcilroy, GD, Welch, Andy, Emma K. Lees (181936), Lees Emma K., Robert Judson, Benjamin G Neel, Delibegovic, M, Kendra K. Bence, Delibegović Mirela, Carl Owen, Owen Carl, Mcilroy, George D., Emma K. Lees, Alicja Czopek, Kahn, BB, George D. Mcilroy   +82 more
core   +1 more source

MAPK Phosphatase-1 Deficiency Exacerbates the Severity of Imiquimod-Induced Psoriasiform Skin Disease

Frontiers in Immunology, 2018
Persistent activation of mitogen-activated protein kinase (MAPK) is believed to be involved in psoriasis pathogenesis. MAPK phosphatase-1 (MKP-1) is an important negative regulator of MAPK activity, but the cellular and molecular mechanisms of MKP-1 in ...
Weiheng Zhao, Shuxiu Xiao, Hongjin Li, Tingting Zheng, Jian Huang, Ran Hu, Baohua Zhang, Xinguang Liu, Gonghua Huang   +8 more
doaj   +1 more source