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A Metal-Dependent Form of Protein Phosphatase 2A
Biochemical and Biophysical Research Communications, 1995Highly purified bovine heart protein phosphatase 2A catalytic subunit lost virtually all of its activity during storage at -70 degrees. When the enzyme was preincubated with Co2+, over 35% of the original activity was restored. Freshly prepared protein phosphatase 2A purified from bovine heart was stimulated at least 3 to 4-fold by pretreatment with ...
L, Cai +3 more
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Protein phosphatase 2A — a ‘ménage à trois’
Trends in Cell Biology, 1994Protein phosphorylation is probably the major regulatory mechanism employed by eukaryotic cells. Much work has been devoted to the role of protein kinases and their modulation by hormones, growth factors and neurotransmitters. It is now appreciated that protein phosphatases are also key players in actively regulating many cellular processes.
R E, Mayer-Jaekel, B A, Hemmings
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11 Reversible methylation of protein phosphatase 2A
2006PP2A has been shown to be methylated at the C-terminal leucine residue of the catalytic subunit by a specific 38 kDa methyltransferase (LCMT1) and demethylated by a specific 44-kDa methylesterase (PME-1). This reversible methylation does not seem to drastically change the PP2A activity but is shown to be a modulating factor in the binding of the third ...
Sari, Longin, Jozef, Goris
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Regulation of protein kinase cascades by protein phosphatase 2A
Trends in Biochemical Sciences, 1999Many protein kinases themselves are regulated by reversible phosphorylation. Upon cell stimulation, specific kinases are transiently phosphorylated and activated. Several of these protein kinases are substrates for protein phosphatase 2A (PP2A), and PP2A appears to be the major kinase phosphatase in eukaryotic cells that downregulates activated protein
Millward TA, Zolnierowicz S, Hemmings BA
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Protein Phosphatase 2A as a Potential Target for Anticancer Therapy
Anti-Cancer Agents in Medicinal Chemistry, 2011The kinase oncogenes are well-characterized drivers of cancer development, and several targeted therapies focused on both specific and selectively nonselective kinase inhibitors have now been approved for clinical use. In contrast, much less is known about the role of protein phosphatases, although modulation of their activities might form the ...
Peter, Kalev, Anna A, Sablina
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Role of serine/threonine protein phosphatase 2A in cancer
Cancer Letters, 2001The serine/threonine protein phosphatase 2A (PP2A) appears to be critically involved in cellular growth control and potentially in the development of cancer. A few studies indicated that this enzyme might actually exert tumor suppressive function. However, other findings demonstrated the requirement for PP2A in cell growth and survival, which is not a ...
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Targeting Protein Phosphatases in Cancer Immunotherapy and Autoimmune Disorders
Nature Reviews Drug Discovery, 2023Nunzio Bottini, Stephanie M Stanford
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Plant Protein Phosphatases: What Do We Know About Their Mechanism of Action?
FEBS Journal, 2021Swati Mahiwal +2 more
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Prostatic Acid Phosphatase: Where Are We?
Ca-A Cancer Journal for Clinicians, 1978T M Chu, G P Murphy
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