Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1 [PDF]
, 2020 Cancer therapeutics: Extending a drug's reach A new drug that blocks heat shock proteins (HSPs), helper proteins that are co-opted by cancer cells to promote tumor growth, shows promise for cancer treatment.
Chae, Young Chan +10 more
core +1 more source
Protein phosphatase 2A: a target for anticancer therapy. [PDF]
The Lancet Oncology, 2013 Protein phosphatase 2A (PP2A), one of the main serine-threonine phosphatases in mammalian cells, maintains cell homoeostasis by counteracting most of the kinase-driven intracellular signalling pathways. Unrestrained activation of oncogenic kinases together with inhibition of tumour suppressors is often required for development of cancer.
D. Perrotti, P. Neviani
semanticscholar +3 more sources
A crosstalk between phosphorylation and ubiquitination of BNIP3 regulates mitophagy under hypoxia
Autophagy Reports, 2023 BNIP3 (BCL2/adenovirus e1B 19 kDa protein interacting protein 3) is a mitochondrial outer membrane protein that is sensitive to hypoxia and mediates mitophagy, a process important for mitochondrial quality control and to maintain energetic and redox ...
Yun-Ling He +4 more
doaj +1 more source
Neurobiology of Disease, 2021 LRRK2 is a highly phosphorylated multidomain protein and mutations in the gene encoding LRRK2 are a major genetic determinant of Parkinson's disease (PD).
Matthieu Drouyer +19 more
doaj +1 more source
Protein kinase A (PKA) phosphorylation of Shp2 inhibits its phosphatase activity and modulates ligand specificity. [PDF]
, 2015 Pathological cardiac hypertrophy (an increase in cardiac mass resulting from stress-induced cardiac myocyte growth) is a major factor underlying heart failure.
Burmeister, BT +5 more
core +1 more source
Interaction of nucleoredoxin with protein phosphatase 2A
FEBS Letters, 2006 A trimeric protein phosphatase 2A (PP2AT55) composed of the catalytic (PP2Ac), structural (PR65/A), and regulatory (PR55/B) subunits was isolated from rabbit skeletal muscle by thiophosphorylase affinity chromatography, and contained two additional proteins of 54 and 55 kDa, respectively.
Lechward, Katarzyna +5 more
openaire +2 more sources
Effects of Newly Synthesized DCP-LA-Phospholipids on Protein Kinase C and Protein Phosphatases
Cellular Physiology and Biochemistry, 2013 Background/Aims: The linoleic acid derivative DCP-LA selectively activates PKCε and inhibits protein phosphatase 1 (PP1). In the present study, we have newly synthesized phosphatidyl-ethanolamine, -serine, -choline, and -inositol containing DCP-LA at the
Takeshi Kanno +5 more
doaj +1 more source
Differing calcification processes in cultured vascular smooth muscle cells and osteoblasts [PDF]
, 2019 © 2019 Published by Elsevier Inc.Arterial medial calcification (AMC) is the deposition of calcium phosphate mineral, often as hydroxyapatite, inthe medial layer of the arteries.
Arnett, Timothy R +6 more
core +5 more sources
Protein Phosphatase 2A in the Regulatory Network Underlying Biotic Stress Resistance in Plants
Frontiers in Plant Science, 2016 Biotic stress factors pose a major threat to plant health and can significantly deteriorate plant productivity by impairing the physiological functions of the plant.
Guido Durian +4 more
semanticscholar +1 more source
Retrovirology, 2005 Background HIV-1 Tat protein recruits human positive transcription elongation factor P-TEFb, consisting of CDK9 and cyclin T1, to HIV-1 transactivation response (TAR) RNA.
Brady John +4 more
doaj +1 more source