Results 41 to 50 of about 4,239,129 (300)

Generation of active protein phosphatase 2A is coupled to holoenzyme assembly. [PDF]

PLoS Biology, 2007
Protein phosphatase 2A (PP2A) is a prime example of the multisubunit architecture of protein serine/threonine phosphatases. Until substrate-specific PP2A holoenzymes assemble, a constitutively active, but nonspecific, catalytic C subunit would constitute
Hans Hombauer, David Weismann, Ingrid Mudrak, Claudia Stanzel, Thomas Fellner, Daniel H Lackner, Egon Ogris   +6 more
doaj   +1 more source

Detection of a protein phosphatase 2A holoenzyme in Neurospora crassa. [PDF]

, 1999
A high molecular mass (about 280 kDa) protein phosphatase 2A holoenzyme was detected in a crude N. crassa extract by gel filtration coupled with phosphatase activity assays. According to Western blot analysis the holoenzyme consists of a 36-kDa catalytic
Yarden, Oded, Dombradi, Viktor, Oded Yarden, Yatzkan, Einat, Viktor Dombradi, Einat Yatzkan   +5 more
core   +1 more source

The G-protein-coupled receptor phosphatase: a protein phosphatase type 2A with a distinct subcellular distribution and substrate specificity. [PDF]

, 1995
Phosphorylation of G-protein-coupled receptors plays an important role in regulating their function. In this study the G-protein-coupled receptor phosphatase (GRP) capable of dephosphorylating G-protein-coupled receptor kinase-phosphorylated receptors is
Pitcher, JA, Lefkowitz, RJ, Csortos, C, DePaoli-Roach, AA, Payne, ES   +4 more
core   +1 more source

Effects of Newly Synthesized DCP-LA-Phospholipids on Protein Kinase C and Protein Phosphatases

Cellular Physiology and Biochemistry, 2013
Background/Aims: The linoleic acid derivative DCP-LA selectively activates PKCε and inhibits protein phosphatase 1 (PP1). In the present study, we have newly synthesized phosphatidyl-ethanolamine, -serine, -choline, and -inositol containing DCP-LA at the
Takeshi Kanno, Ayako Tsuchiya, Tadashi Shimizu, Syuhei Nakao, Akito Tanaka, Tomoyuki Nishizaki   +5 more
doaj   +1 more source

Defects of protein phosphatase 2A causes corticosteroid insensitivity in severe asthma. [PDF]

PLoS ONE, 2011
BACKGROUND: Corticosteroid insensitivity is a major barrier of treatment for some chronic inflammatory diseases, such as severe asthma, but the molecular mechanism of the insensitivity has not been fully elucidated.
Yoshiki Kobayashi, Nicolas Mercado, Peter J Barnes, Kazuhiro Ito   +3 more
doaj   +1 more source

Phosphorylation Promotes the Accumulation of PERIOD Protein Foci

Research, 2023
Circadian clock drives the 24-h rhythm in our behavior and physiology. The molecular clock consists of a series of transcriptional/translational feedback loops operated by a number of clock genes.
Mengna Li, Shujing Li, Luoying Zhang
doaj   +1 more source

Functional cdc25C dual-specificity phosphatase is required for S-phase entry in human cells [PDF]

, 2003
In view of the common regulatory mechanism that induces transcription of tie mitotic phosphatase cdc25C and cyclin A at the beginning of S-phase, we investigated whether cdc25C was required for S-phase transit.
Patric Turowski, Franckhauser, Céline, Ned J. C. Lamb, Lamb, Ned,, Celine Franckhauser, Fernandez, A, Lamb, NJC, Turowski, P, Fernandez, Anne, Turowski, Patric, Morris, May, Franckhauser, C, Vaglio, P, Vaglio, Philippe, Morris, MC, Lamb, Ned, J., Anne Fernandez, May C. Morris, Anne Fern, Philippe Vaglio   +19 more
core   +1 more source

Therapeutic relevance of the protein phosphatase 2A in cancer

Oncotarget, 2016
Chromosomal Instability (CIN) is regarded as a unifying feature of heterogeneous tumor populations, driving intratumoral heterogeneity. Polo-Like Kinase 1 (PLK1), a serine-threonine kinase that is often overexpressed across multiple tumor types, is one of the key regulators of CIN and is considered as a potential therapeutic target.
Cunningham, Chelsea E., Li, Shuangshuang, Vizeacoumar, Frederick S., Bhanumathy, Kalpana Kalyanasundaram, Lee, Joo Sang, Parameswaran, Sreejit, Furber, Levi, Abuhussein, Omar, Paul, James M., McDonald, Megan, Templeton, Shaina D., Shukla, Hersh, El Zawily, Amr M., Boyd, Frederick, Alli, Nezeka, Mousseau, Darrell D., Geyer, Ron, Bonham, Keith, Anderson, Deborah H., Yan, Jiong, Yu-Lee, Li-Yuan, Weaver, Beth A., Uppalapati, Maruti, Ruppin, Eytan, Sablina, Anna, Freywald, Andrew, Vizeacoumar, Franco J.   +26 more
openaire   +3 more sources

From Basic Science to Clinical Practice: The Role of Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A)/p90 in Cancer

Frontiers in Genetics, 2023
Cancerous inhibitor of protein phosphatase 2A (CIP2A), initially reported as a tumor-associated antigen (known as p90), is highly expressed in most solid and hematological tumors. The interaction of CIP2A/p90, protein phosphatase 2A (PP2A), and c-Myc can
Beibei Chen, Beibei Chen, Huihui Hu, Huihui Hu, Xiaobing Chen, Xiaobing Chen   +5 more
doaj   +1 more source

Protein tyrosine phosphatase TbPTP1:A molecular switch controlling life cycle differentiation in trypanosomes [PDF]

, 2006
Differentiation in African trypanosomes (Trypanosoma brucei) entails passage between a mammalian host, where parasites exist as a proliferative slender form or a G0-arrested stumpy form, and the tsetse fly.
Szoor, Balazs; id_orcid, Matthews, Keith R., Helen McElhinney, Tabernero, Lydia, Wilson, Jude, Szöor, Balázs, Keith R. Matthews, Matthews, Keith R; id_orcid, Lydia Tabernero, Tabernero, Lydia; id_orcid, McElhinney, Helen, Balázs Szöőr, Jude Wilson   +12 more
core   +1 more source