Results 31 to 40 of about 4,239,129 (300)

Establishment of a PPP2CA homozygous knockout human embryonic stem cell line via CRISPR/Cas9 system

Stem Cell Research, 2023
Protein phosphatase 2A (PPP2CA) is one of the four main Ser/Thr phosphatase enzymes, which involved in the negative control of cell growth and division. PPP2CA is the main protein phosphatase in the heart, which regulates Ca (2+) through a series of ion ...
Tongbin Ding, Zhe Gao, Hang Liu, Yuan Li, Shichao Liu, Liguo Jian   +5 more
doaj   +1 more source

Isolation and partial characterization of a protein with HMG-CoA reductase phosphatase activity associated with rat liver microsomal membranes.

Journal of Lipid Research, 1991
Several rat liver HMG-CoA-reductase (HMG-CoA-Rd) phosphatase activities have been shown to be associated with the endoplasmic reticulum. These activities were not due to glycogen contamination, as judged not only from different patterns of solubilization
G Asins, D Serra, FG Hegardt
doaj   +1 more source

Protein phosphatase 2A in Alzheimer's disease

Pathophysiology, 2009
Protein phosphatase 2A (PP2A) is the predominant serine/threonine phosphatase in eukaryotic cells. In Alzheimer's disease (AD), PP2A activity is decreased. Decreased PP2A activity is suggested to be involved in NFT formation and neurodegeneration. PP2A is also involved in APP secreting pathway, thus probably participating the Abeta production. Based on
Rong, Liu, Jian-Zhi, Wang
openaire   +2 more sources

Marine Longilenes, Oxasqualenoids with Ser-Thr Protein Phosphatase 2A Inhibition Activity

Marine Drugs, 2018
The red seaweed Laurencia viridis is a rich source of oxygenated secondary metabolites that were derived from squalene. We report here the structures of three novel compounds, (+)-longilene peroxide (1), longilene (2), and (+)-prelongilene (3) that were ...
Francisco Cen-Pacheco, Claudia Pérez Manríquez, María Luisa Souto, Manuel Norte, José Javier Fernández, Antonio Hernández Daranas   +5 more
doaj   +1 more source

Mechanisms of the scaffold subunit in facilitating protein phosphatase 2A methylation. [PDF]

PLoS ONE, 2014
The function of the biologically essential protein phosphatase 2A (PP2A) relies on formation of diverse heterotrimeric holoenzymes, which involves stable association between PP2A scaffold (A) and catalytic (C or PP2Ac) subunits and binding of variable ...
Vitali Stanevich, Aiping Zheng, Feng Guo, Li Jiang, Nathan Wlodarchak, Yongna Xing   +5 more
doaj   +1 more source

Protein phosphatase 2A: a target for anticancer therapy [PDF]

The Lancet Oncology, 2013
Protein phosphatase 2A (PP2A), one of the main serine-threonine phosphatases in mammalian cells, maintains cell homoeostasis by counteracting most of the kinase-driven intracellular signalling pathways. Unrestrained activation of oncogenic kinases together with inhibition of tumour suppressors is often required for development of cancer.
Danilo, Perrotti, Paolo, Neviani
openaire   +2 more sources

A stable association with PME‐1 may be dispensable for PP2A demethylation – implications for the detection of PP2A methylation and immunoprecipitation

FEBS Open Bio, 2018
Reversible methyl‐esterification (methylation) of Leu309 in the protein phosphatase 2A catalytic subunit (PP2Ac) is essential for proper biogenesis of the PP2A holoenzyme.
Ryotaro Yabe, Shunya Tsuji, Satoru Mochida, Tsuyoshi Ikehara, Tatsuya Usui, Takashi Ohama, Koichi Sato   +6 more
doaj   +1 more source

Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A

Neurobiology of Disease, 2008
The down-regulation of protein phosphatase 2A (PP2A) activity is thought to play an important role in the formation of tau hyperphosphorylation in the Alzheimer's disease (AD) brain. Methylation of the PP2A catalytic subunit at the L309 site can potently
Xin-Wen Zhou, Jan-Åke Gustafsson, Heikki Tanila, Cecilia Bjorkdahl, Rong Liu, Bengt Winblad, Jin-Jing Pei   +6 more
doaj   +1 more source

Free Fatty Acids Inhibit Protein Tyrosine Phosphatase 1B and Activate Akt

Cellular Physiology and Biochemistry, 2013
Background/Aims: Accumulating evidence has suggested that free fatty acids (FFAs) interact with protein kinases and protein phosphatases. The present study examined the effect of FFAs on protein phosphatases and Akt.
Eisuke Shibata, Takeshi Kanno, Ayako Tsuchiya, Kohzo Kuribayashi, Chiharu Tabata, Takashi Nakano, Tomoyuki Nishizaki   +6 more
doaj   +1 more source

Cancerous inhibitor of protein phosphatase 2A (CIP2A) modifies energy metabolism via 5′ AMP-activated protein kinase signalling in malignant cells [PDF]

, 2019
Cancerous inhibitor of protein phosphatase 2A (CIP2A) is an adverse biomarker across many malignancies. Using K562 cells engineered to have high or low CIP2A expression, we show that high CIP2A levels significantly bias cellular energy production towards
Clark, Richard E., Scott, Laura, Lucas, Claire, Austin, James A., Glenn, Mark A., Dunn, Karen, Jenkins, Rosalind E., Austin, Gemma M., Austin, James A, Clark, Richard E, Glenn, Mark A, Jenkins, Rosalind E, Lucas, Claire M, Austin, Gemma M   +13 more
core   +1 more source