Results 21 to 30 of about 4,239,129 (300)

MicroRNA exporter HuR clears the internalized pathogens by promoting pro‐inflammatory response in infected macrophages

EMBO Molecular Medicine, 2020
HuR is a miRNA derepressor protein that can act as miRNA sponge for specific miRNAs to negate their action on target mRNAs. Here we have identified how HuR, by inducing extracellular vesicles‐mediated export of miRNAs, ensures robust derepression of ...
Avijit Goswami, Kamalika Mukherjee, Anup Mazumder, Satarupa Ganguly, Ishita Mukherjee, Saikat Chakrabarti, Syamal Roy, Shyam Sundar, Krishnananda Chattopadhyay, Suvendra N Bhattacharyya   +9 more
doaj   +1 more source

The TriTryp phosphatome:analysis of the protein phosphatase catalytic domains [PDF]

, 2007
Background The genomes of the three parasitic protozoa Trypanosoma cruzi, Trypanosoma brucei and Leishmania major are the main subject of this study. These parasites are responsible for devastating human diseases known as Chagas disease, African sleeping
Szoor, Balazs; id_orcid, Tabernero, Lydia, Tabernero, Lydia; id_orcid, McElhinney, Helen, Huxley-Jones, Julie, Julie Huxley-Jones, Brenchley, Rachel, Tariq, Humera, Helen McElhinney, Keith Matthews, Matthews, Keith; id_orcid, Rachel Brenchley, Robert Stevens, Szöor, Balázs, Humera Tariq, Lydia Tabernero, Stevens, Robert, Matthews, Keith, Balazs Szoor   +18 more
core   +1 more source

Memantine Attenuates Alzheimer's Disease-Like Pathology and Cognitive Impairment.

PLoS ONE, 2015
Deficiency of protein phosphatase-2A is a key event in Alzheimer's disease. An endogenous inhibitor of protein phosphatase-2A, inhibitor-1, I1PP2A, which inhibits the phosphatase activity by interacting with its catalytic subunit protein phosphatase-2Ac,
Xiaochuan Wang, Julie Blanchard, Inge Grundke-Iqbal, Khalid Iqbal   +3 more
doaj   +1 more source

Developmental Expression of Protein Phosphatase 2A in the Kidney [PDF]

Journal of the American Society of Nephrology, 1999
Abstract. Although a number of growth and transcription factors are known to regulate renal growth and development, the signal transduction molecules necessary to mediate these developmental signals are relatively unknown.
A D, Everett, C, Xue, T, Stoops
openaire   +2 more sources

Purification and characterization of a protein inhibitor from rat liver that inhibits type 1 protein phosphatase when 3-hydroxy-3-methylglutaryl CoA reductase is the substrate.

Journal of Lipid Research, 1990
A protein inhibitor of HMG-CoA reductase phosphatase activity from rat liver was purified to homogeneity. The protein was purified 4,000-fold with an overall yield of 4%. The purified protein had a molecular mass of 31 kDa.
D Serra, G Asins, FG Hegardt
doaj   +1 more source

Sex-specific regulation of the cardiac transcriptome by the protein phosphatase 2A regulatory subunit B55α. [PDF]

NPJ Metab Health Dis
Sex-specific regulation of the cardiac transcriptome by the protein phosphatase 2A regulatory subunit ...
Sergienko NM, Trewin AJ, Kiriazis H, Raaijmakers AJA, Donner DG, Garside VC, Smith KA, Bell JR, Mellor KM, Delbridge LMD, McMullen JR, Weeks KL.   +11 more
europepmc   +2 more sources

Enhanced insulin sensitivity associated with provision of mono and polyunsaturated fatty acids in skeletal muscle cells involves counter modulation of PP2A [PDF]

, 2014
Aims/HypothesisReduced skeletal muscle insulin sensitivity is a feature associated with sustained exposure to excess saturated fatty acids (SFA), whereas mono and polyunsaturated fatty acids (MUFA and PUFA) not only improve insulin sensitivity but blunt ...
Hage Hassan, Rima, Hundal, Harinder S, Gray, Alexander; id_orcid, Lipina Christopher, Hundal, Harinder S., Alexander Gray, Hajduch, Eric, Rima Hage Hassan, David Magill, Eric Hajduch, Hage Hassan Rima, Nardi, Francesca, Francesca Nardi, Hajduch Eric, Magill David, Gray, Alexander, Hundal Harinder S., Lipina, Christopher, Nardi Francesca, Harinder S Hundal, Magill, David, Christopher Lipina, Gray Alexander   +22 more
core   +2 more sources

Crystallization of the Aα subunit of protein phosphatase 2A [PDF]

Protein Science, 1996
AbstractThe Aα subunit of human protein phosphatase 2A forms crystals in space group P21 with cell dimensions a = 104.0, b = 174.9, c = 168.2 Å, and β angle = 90.2°. At cryogenic temperatures, the crystals diffracted to a resolution limit of ∼ 3.0 Å.
M O, Skidmore, M R, Sawaya, S, Parkin, B, Rupp, H, Hope, S J, Everse, G, Walter   +6 more
openaire   +2 more sources

Supplementary Figure from Protein Phosphatase 2A–Dependent Mitotic hnRNPA1 Dephosphorylation and TERRA Formation Facilitate Telomere Capping

, 2022
Supplementary Figure from Protein Phosphatase 2A–Dependent Mitotic hnRNPA1 Dephosphorylation and TERRA Formation Facilitate Telomere ...
Jiang-Dong Sui (15099089), Qing-Ming Jiang (15099095), Hao-Nan Yang (9022982), Jing Zhang (23775), Meng-Qi Yang (8565567), Yong-Zhong Wu (13921485), Zheng Tang (1297200), Benjamin P.C. Chen (15099092), Hong-Lei Tu (13921491), Ying Wang (11406), Ping Huang (30439), Nuo-Han Wang (13921479)   +11 more
core   +1 more source

Interaction of nucleoredoxin with protein phosphatase 2A

FEBS Letters, 2006
A trimeric protein phosphatase 2A (PP2AT55) composed of the catalytic (PP2Ac), structural (PR65/A), and regulatory (PR55/B) subunits was isolated from rabbit skeletal muscle by thiophosphorylase affinity chromatography, and contained two additional proteins of 54 and 55 kDa, respectively.
Lechward, Katarzyna, Sugajska, Ewa, de Baere, Ivo, Goris, Jozef, Hemmings, Brian A., Zolnierowicz, Stanislaw   +5 more
openaire   +2 more sources