Results 251 to 260 of about 2,399,730 (304)

PTEN modulates mitochondrial dysfunction in podocytes via the PINK1/Parkin signal pathway. [PDF]

Transl Pediatr
Ren Q, Yu S.
europepmc   +1 more source

Evidence that the protein phosphatase activity of PTEN contributes to embryonic development and tumour suppression in mice

Tibarewal P, Spinelli L, Kriplani N, Wise H, Poncet N, Marzano G, Anderson KE, Grzes KM, Varyova Z, Adil M, Downes CP, Hawkins PT, Stephens LR, Storey KG, Cantrell DA, Vanhaesebroeck B, Leslie NR.   +16 more
europepmc   +1 more source

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Anp32e (Cpd1) and related protein phosphatase 2 inhibitors

The Cerebellum, 2008
Mouse Anp32e (Acidic leucine-rich nuclear phosphoprotein 32 family, member e: NM_023210, P97822, formerly Cpd1), a protein identified in postnatal cerebellum by differential display, belongs to the superfamily of leucine rich repeat (LRR) proteins and to the Acidic Nuclear Phosphoprotein 32 (ANP32) family of protein phosphatase 2 (PPP2, formerly PP2A ...
T. Santa-Coloma
semanticscholar   +3 more sources

SHP-2, SH2-containing protein tyrosine phosphatase-2.

The international journal of biochemistry & cell biology, 1998
SHP-2 is an ubiquitously expressed cytosolic protein tyrosine phosphatase composed of two amino-terminal SH2 domains, a central phosphatase domain and a carboxy-terminal tail. Upon activation of cells with different stimuli, SHP-2 is recruited to the plasma membrane where it can associate with a number of tyrosine phosphorylated molecules, including ...
M. Stein-Gerlach, C. Wallasch, A. Ullrich   +2 more
semanticscholar   +3 more sources

MicroRNA-222 Promotes Invasion and Metastasis of Papillary Thyroid Cancer Through Targeting Protein Phosphatase 2 Regulatory Subunit B Alpha Expression

Thyroid, 2018
Background: Increasing evidence indicates that microRNA dysfunction is involved in the pathogenesis and progression of cancer. MicroRNA-222 (miR-222) is upregulated in papillary thyroid carcinoma (PTC).
Yanrui Huang, Shuang Yu, Siting Cao, Yali Yin, Shubin Hong, H. Guan, Yanbing Li, Haipeng Xiao   +7 more
semanticscholar   +1 more source

Inhibitor Binding Sites in the Protein Tyrosine Phosphatase SHP-2

Mini-Reviews in Medicinal Chemistry, 2020
Protein tyrosine phosphatase 2 (SHP-2) has long been proposed as a cancer drug target. Several small-molecule compounds with different mechanisms of SHP-2 inhibition have been reported, but none are commercially available. Pool selectivity over protein tyrosine phosphatase 1 (SHP-1) and a lack of cellular activity have hindered the development of ...
Haonan Zhang, Zhengquan Gao, Chunxiao Meng, Xiangqian Li, Dayong Shi   +4 more
openaire   +2 more sources