Results 271 to 280 of about 625,556 (313)

Beyond cartilage degeneration: osteoarthritis as a systems failure of inflammation regulation. [PDF]

Front Med (Lausanne)
Bar-Or D, Williams J, Hausburg M, Thomas G, Bar-Or R.   +4 more
europepmc   +1 more source

Development of bone alkaline phosphatase-specific monoclonal antibodies and immunoassay exhibiting low cross-reactivity to liver isoform. [PDF]

JBMR Plus
Kimura T, Ojima S, Doi K.
europepmc   +1 more source

Phosphosite-specific co-regulation networks of MELK kinase: insights from integrative global phosphoproteomes. [PDF]

J Genet Eng Biotechnol
Khan NA, Fahma A, Mahin A, Gopalakrishnan AP, Shivamurthy PB, Ummar S, Rajeev AC, Raju R.   +7 more
europepmc   +1 more source

Unresolved mechanisms: a hypothesized spatial regulation of myosin light chain phosphorylation within the walls of resistance arteries. [PDF]

Front Physiol
Sun Z, Hill MA.
europepmc   +1 more source

Alleviating the Adverse Effects of Lipopolysaccharide on Production Performance, Immune Function, and Intestinal Damage in Broilers via Dietary Alkaline Phosphatase. [PDF]

Animals (Basel)
Wang Q, Zhou Y, Qiu Q, Zhang W, Rajput SA, Qi D, Lei M.   +6 more
europepmc   +1 more source

The SHIP1-inflammatory-lipid axis in Alzheimer's disease: from genetic risk to spatiotemporal mechanistic insights. [PDF]

J Neuroinflammation
Xi R, Zheng X, Zhao J, Fu Y.
europepmc   +1 more source

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Inhibitor Binding Sites in the Protein Tyrosine Phosphatase SHP-2

Mini-Reviews in Medicinal Chemistry, 2020
Protein tyrosine phosphatase 2 (SHP-2) has long been proposed as a cancer drug target. Several small-molecule compounds with different mechanisms of SHP-2 inhibition have been reported, but none are commercially available. Pool selectivity over protein tyrosine phosphatase 1 (SHP-1) and a lack of cellular activity have hindered the development of ...
Haonan Zhang, Zhengquan Gao, Chunxiao Meng, Xiangqian Li, Dayong Shi   +4 more
openaire   +2 more sources

Effects of hibernation on regulation of mammalian protein phosphatase type-2-A

Cryobiology, 2013
Hibernation is used by many small mammals for winter survival. Animals undergo cycles of deep torpor characterized by strong reductions in metabolic rate, body temperature, and all physiological activities. One prominent biochemical mechanism involved in regulating coordinated transitions to and from the hypometabolic state is reversible protein ...
Cheng-Wei, Wu, Anthony J, Reardon, Kenneth B, Storey   +2 more
openaire   +2 more sources

Specific dephosphorylation of Janus Kinase 2 by protein tyrosine phosphatases

PROTEOMICS, 2014
Many protein kinases are activated through phosphorylation of an activation loop thereby turning on downstream signaling pathways. Activation of JAK2, a nonreceptor tyrosine kinase with an important role in growth factor and cytokine signaling, requires phosphorylation of the 1007 and 1008 tyrosyl residues.
Jianzhuo, Li, Xidong, Liu, Huiying, Chu, Xueqi, Fu, Tianbao, Li, Lianghai, Hu, Shu, Xing, Guohui, Li, Jingkai, Gu, Zhizhuang Joe, Zhao   +9 more
openaire   +2 more sources

Anp32e (Cpd1) and related protein phosphatase 2 inhibitors

The Cerebellum, 2003
Mouse Anp32e (Acidic leucine-rich nuclear phosphoprotein 32 family, member e: NM_023210, P97822, formerly Cpd1), a protein identified in postnatal cerebellum by differential display, belongs to the superfamily of leucine rich repeat (LRR) proteins and to the Acidic Nuclear Phosphoprotein 32 (ANP32) family of protein phosphatase 2 (PPP2, formerly PP2A ...
openaire   +2 more sources