Results 261 to 270 of about 887,918 (307)

Research progress on protein tyrosine phosphatase A from Mycobacterium tuberculosis. [PDF]

Front Immunol
Cai Y, Zhang L.
europepmc   +1 more source

Sphingomonas paucimobilis‐Driven Epithelial–Endothelial Transition in Adenomyosis Pathogenesis

Advanced Science, EarlyView.
This study identifies epithelial–endothelial transition (EET) as a novel adenomyosis pathogenic mechanism driven by Sphingomonas paucimobilis colonization. Systematic inhibitor experiments validate a TNFα→NF‐κB→MMP signaling cascade essential for EET. Critically, bacterial culture supernatant fails to induce pathological changes, demonstrating viable ...
Peigen Chen, Hao Shi, Junxian He, Ziyu Liu, Yuanyuan Zhu, Xiaoyan Liang, Guihua Liu, Xing Yang   +7 more
wiley   +1 more source

Comparison of vitamin D, parathyroid hormone (PTH), and bone metabolism markers in hip fracture patients by fracture type and control group. [PDF]

Ulus Travma Acil Cerrahi Derg
Kemah B, Söylemez MS, Erinç S, Ozkan K, Poyanli O.   +4 more
europepmc   +1 more source

Single‐Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis

Advanced Science, EarlyView.
This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu, Ting He, Yu Qian, Jia Li, Bowei Ni, Xiaojie Xu, Huanbo Wang, Peng Wang, Guoqing Cao, Siqi Ying, Guangyu Ding, Rong Wang, Zenghui Gu, Wei Li, Zhentao Man, Houfeng Zheng, Zhaohua Zhu, Zhen Li, Qingjun Meng, Chao Zheng, Liu Yang   +20 more
wiley   +1 more source

The adeno-associated virus Rep proteins target PP4:SMEK1 by preventing substrate recruitment. [PDF]

PLoS Pathog
Vandewinkel B, Torrekens S, Claes Z, Bollen M, Henckaerts E.   +4 more
europepmc   +1 more source

The protein phosphatase 2A-B56α complex regulates N-Myc degradation in neuroblastoma. [PDF]

J Biol Chem
Tran BD, Peris I, Wurman E, Huang A, Hodges Onishi G, Hu J, Avelar RA, Newman EA, DiFeo A, O'Connor CM, Narla G.   +10 more
europepmc   +1 more source

Mapping of PTP1B, TCPTP, SHP2, and Putative Substrates Reveals Novel Networks in Glomerular Podocytes. [PDF]

J Cell Physiol
LeBleu G, Hsu MF, Ito Y, Liang SY, Ma KL, Meng TC, Haj FG.   +6 more
europepmc   +1 more source

Rapid and Label-Free Structural Proteomics Using One-Step Swift Trypsin LiP-MS. [PDF]

ACS Omega
Miyashita Y, Konno R, Ogasawara S, Okuda Y, Takamuku Y, Moriya T, Saito T, Murata T, Ohara O, Kawashima Y.   +9 more
europepmc   +1 more source

Association of serum ferritin with bone turnover markers and bone mineral density in children and adolescents: Finding from NHANES 1999-2002. [PDF]

J Int Med Res
Zheng W, Chen Z, Chen H, Pan Y, Chen J.
europepmc   +1 more source

Correction to "Gallium Complex K6 Inhibits Colorectal Cancer by Increasing ROS Levels to Induce DNA Damage and Enhance Phosphatase and Tensin Homolog Activity". [PDF]

MedComm (2020)
europepmc   +1 more source