Results 261 to 270 of about 2,399,730 (304)

Specific dephosphorylation of Janus Kinase 2 by protein tyrosine phosphatases

PROTEOMICS, 2014
Many protein kinases are activated through phosphorylation of an activation loop thereby turning on downstream signaling pathways. Activation of JAK2, a nonreceptor tyrosine kinase with an important role in growth factor and cytokine signaling, requires phosphorylation of the 1007 and 1008 tyrosyl residues.
Jianzhuo, Li, Xidong, Liu, Huiying, Chu, Xueqi, Fu, Tianbao, Li, Lianghai, Hu, Shu, Xing, Guohui, Li, Jingkai, Gu, Zhizhuang Joe, Zhao   +9 more
openaire   +2 more sources

Effects of hibernation on regulation of mammalian protein phosphatase type-2-A

Cryobiology, 2013
Hibernation is used by many small mammals for winter survival. Animals undergo cycles of deep torpor characterized by strong reductions in metabolic rate, body temperature, and all physiological activities. One prominent biochemical mechanism involved in regulating coordinated transitions to and from the hypometabolic state is reversible protein ...
Cheng-Wei, Wu, Anthony J, Reardon, Kenneth B, Storey   +2 more
openaire   +2 more sources

Druggable cancer phosphatases

Science Translational Medicine, 2021
Progress has been made in pharmacological targeting of tumor suppressor and oncogenic phosphatases for cancer therapy. The phosphorylation status of oncoproteins is regulated by both kinases and phosphatases.
J. Vainonen, M. Momeny, J. Westermarck
semanticscholar   +1 more source

Recent Advances of SHP2 Inhibitors in Cancer Therapy: Current Development and Clinical Application.

Journal of Medicinal Chemistry, 2020
SHP2 (Src homology-2 domain-containing protein tyrosine phosphatase-2) is a non-receptor protein tyrosine phosphatase that removes tyrosine phosphorylation.
Xinrui Yuan, Hong Bu, Jinpei Zhou, Chao-Yie Yang, Huibin Zhang   +4 more
semanticscholar   +1 more source

Targeting SHP2 as a promising strategy for cancer immunotherapy.

Pharmacological Research, 2019
Src homology 2 (SH2)-containing protein tyrosine phosphatase 2 (SHP2) is a major phosphatase involved in several cellular processes. In recent years, SHP2 has been the focus of significant attention in human diseases, particular in cancer.
Qianqian Liu, Jiao Qu, Mingxia Zhao, Qiang Xu, Yang Sun   +4 more
semanticscholar   +1 more source

Interconversion of Mn2+-Dependent and -Independent Protein Phosphatase 2A from Human Erythrocytes: Role of Zn2+ and Fe2+ in Protein Phosphatase 2A

Journal of Biochemistry, 1999
Human erythrocyte Mn(2+)-dependent (C'A') and -independent (CA) protein-serine/threonine phosphatase (PP) 2A are composed of 34-kDa catalytic C' and C subunits, in which the metal dependency resides, and 63-kDa regulatory A' and A subunits, respectively.
Y, Nishito, H, Usui, O, Tanabe, M, Shimizu, M, Takeda   +4 more
openaire   +2 more sources

2-Carboxymethylendothal analogues as affinity probes for stabilized protein phosphatase 2A

Bioorganic & Medicinal Chemistry, 1999
Endothal (1diacid) and [3H]cantharidic acid ([3H]CA) bind with high affinity to the catalytic subunit of protein phosphatase 2A (PP2A). PP2A in liver cytosol was greatly stabilized with 30% glycerol as a preliminary step in the potential use of endothal-type derivatives for affinity chromatography.
C W, Laidley, W G, Dauben, Z R, Guo, J Y, Lam, J E, Casida   +4 more
openaire   +2 more sources

Regulation of bone and skeletal development by the SHP-2 protein tyrosine phosphatase

Bone, 2014
Src homology-2 protein tyrosine phosphatase (SHP-2) that is encoded by the PTPN11 gene in humans is an intracellular signaling molecule that couples growth factor receptors to activation of the Ras small GTP-binding protein that regulates cell growth, proliferation and differentiation.
Nobuhiro, Kamiya, Harry K W, Kim, Philip D, King   +2 more
openaire   +2 more sources

Protein phosphatase 2A PR130/B”α:1 subunit binds to the SH2 domain‐containing inositol polyphosphate 5‐phosphatase 2 and prevents epidermal growth factor (EGF)‐induced EGF receptor degradation sustaining EGF‐mediated signaling

The FASEB Journal, 2010
K. Zwaenepoel, J. Goris, C. Erneux, P. Parker, V. Janssens   +4 more
semanticscholar   +1 more source

[Research progress of protein tyrosine phosphatase SHP-2].

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2013
The Src homology-2 domain-containing phosphatase SHP-2 encoded by PTPN11 is an essential component in several signaling pathways.Different types of mutation in SHP-2 have been confirmed in several types of leukemia and solid tumors. Elucidation of the events underlying Shp2-evoked transformation may provide new insights into the novel targets ...
Hong-ke, Cai, Yong-chuan, Deng
openaire   +1 more source