Results 251 to 260 of about 4,194,516 (299)

Protein Phosphatase 2A Activation Promotes Heart Transplant Acceptance in Mice. [PDF]

Transplantation
Zhou X, Xu Q, Li W, Dong N, Stomberski C, Narla G, Lin Z.   +6 more
europepmc   +1 more source

Early life seizures chronically disrupt L-type voltage gated calcium channel regulation of mGluR mediated long term depression via interactions with protein phosphatase 2A. [PDF]

Neurobiol Dis
Bernard PB, Castano AM, Buonarati OR, Camp CR, Hell JW, Benke TA.   +5 more
europepmc   +1 more source

Piezo1 - Serine/threonine-protein phosphatase 2A - Cofilin1 biochemical mechanotransduction axis controls F-actin dynamics and cell migration. [PDF]

Heliyon
Morena F, Argentati C, Caponi S, Lüchtefeld I, Emiliani C, Vassalli M, Martino S.   +6 more
europepmc   +1 more source

Penfluridol inhibits melanoma growth and metastasis through enhancing von Hippel‒Lindau tumor suppressor-mediated cancerous inhibitor of protein phosphatase 2A (CIP2A) degradation. [PDF]

MedComm (2020)
Xu F, Li J, Ai M, Zhang T, Ming Y, Li C, Pu W, Yang Y, Li Z, Qi Y, Xu X, Sun Q, Yuan Z, Xia Y, Peng Y.   +14 more
europepmc   +1 more source

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Protein phosphatase 2A: a panoply of enzymes

Current Opinion in Cell Biology, 2000
Protein phosphatase 2A describes an extended family of intracellular protein serine/threonine phosphatases sharing a common catalytic subunit that regulates a variety of processes by means of diverse regulatory subunits. During the past year, studies have shown that protein phosphatase 2A influences events ranging from the initiation of DNA replication
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Protein phosphatase 2A — a ‘ménage à trois’

Trends in Cell Biology, 1994
Protein phosphorylation is probably the major regulatory mechanism employed by eukaryotic cells. Much work has been devoted to the role of protein kinases and their modulation by hormones, growth factors and neurotransmitters. It is now appreciated that protein phosphatases are also key players in actively regulating many cellular processes.
R E, Mayer-Jaekel, B A, Hemmings
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Assembly and structure of protein phosphatase 2A

Science in China Series C: Life Sciences, 2009
Protein phosphatase 2A (PP2A) represents a conserved family of important protein serine/threonine phosphatases in species ranging from yeast to human. The PP2A core enzyme comprises a scaffold subunit and a catalytic subunit. The heterotrimeric PP2A holoenzyme consists of the core enzyme and a variable regulatory subunit.
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A Metal-Dependent Form of Protein Phosphatase 2A

Biochemical and Biophysical Research Communications, 1995
Highly purified bovine heart protein phosphatase 2A catalytic subunit lost virtually all of its activity during storage at -70 degrees. When the enzyme was preincubated with Co2+, over 35% of the original activity was restored. Freshly prepared protein phosphatase 2A purified from bovine heart was stimulated at least 3 to 4-fold by pretreatment with ...
L, Cai, Y, Chu, S E, Wilson, K K, Schlender   +3 more
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Protein phosphatase 2A regulatory subunits and cancer

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2009
The serine/threonine protein phosphatase (PP2A) is a trimeric holoenzyme that plays an integral role in the regulation of a number of major signaling pathways whose deregulation can contribute to cancer. The specificity and activity of PP2A are highly regulated through the interaction of a family of regulatory B subunits with the substrates ...
Pieter J A, Eichhorn, Menno P, Creyghton, René, Bernards   +2 more
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Role of Protein Phosphatase 2A in Alzheimers Disease

Current Alzheimer Research, 2011
Alzheimer disease (AD) is the most common cause of dementia in adults. Aberrant hyperphosphorylation of microtubule associated protein Tau and neurofilament-M/H is one of the pathological hallmarks of AD. Most of the therapeutic strategies for treating AD are based on the inhibition of protein kinases such as glycogen synthase kinase-3β, cyclin ...
P, Rudrabhatla, H C, Pant
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