Results 11 to 20 of about 6,418,118 (368)

Author Correction: The Aurora B specificity switch is required to protect from non-disjunction at the metaphase/anaphase transition

Nature Communications, 2020
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Joanna R. Kelly, Silvia Martini, Nicola Brownlow, Dhira Joshi, Stefania Federico, Shirin Jamshidi, Svend Kjaer, Nicola Lockwood, Khondaker Miraz Rahman, Franca Fraternali, Peter J. Parker, Tanya N. Soliman   +11 more
doaj   +1 more source

CMG helicase disassembly is controlled by replication fork DNA, replisome components and a ubiquitin threshold

eLife, 2020
The eukaryotic replisome assembles around the CMG helicase, which stably associates with DNA replication forks throughout elongation. When replication terminates, CMG is ubiquitylated on its Mcm7 subunit and disassembled by the Cdc48/p97 ATPase.
Tom D Deegan, Progya P Mukherjee, Ryo Fujisawa, Cristian Polo Rivera, Karim Labib   +4 more
doaj   +1 more source

A novel RLIM/RNF12 variant disrupts protein stability and function to cause severe Tonne–Kalscheuer syndrome

Scientific Reports, 2021
Tonne–Kalscheuer syndrome (TOKAS) is an X-linked intellectual disability syndrome associated with variable clinical features including craniofacial abnormalities, hypogenitalism and diaphragmatic hernia.
Francisco Bustos, Carmen Espejo-Serrano, Anna Segarra-Fas, Rachel Toth, Alison J. Eaton, Kristin D. Kernohan, Meredith J. Wilson, Lisa G. Riley, Greg M. Findlay   +8 more
doaj   +1 more source

The Aurora B specificity switch is required to protect from non-disjunction at the metaphase/anaphase transition

Nature Communications, 2020
In mitosis, Aurora B switches substrate specificity in response to phosphorylation of S227 in the activation loop by a cell cycle-processed active fragment of PKCε.
Joanna R. Kelly, Silvia Martini, Nicola Brownlow, Dhira Joshi, Stefania Federico, Shirin Jamshidi, Svend Kjaer, Nicola Lockwood, Khondaker Miraz Rahman, Franca Fraternali, Peter J. Parker, Tanya N. Soliman   +11 more
doaj   +1 more source

Mapping of a N-terminal α-helix domain required for human PINK1 stabilization, Serine228 autophosphorylation and activation in cells

Open Biology, 2022
Autosomal recessive mutations in the PINK1 gene are causal for Parkinson's disease (PD). PINK1 encodes a mitochondrial localized protein kinase that is a master-regulator of mitochondrial quality control pathways.
Poonam Kakade, Hina Ojha, Olawale G. Raimi, Andrew Shaw, Andrew D. Waddell, James R. Ault, Sophie Burel, Kathrin Brockmann, Atul Kumar, Mohd Syed Ahangar, Ewelina M. Krysztofinska, Thomas Macartney, Richard Bayliss, Julia C. Fitzgerald, Miratul M. K. Muqit   +14 more
doaj   +1 more source

Pathogenic FAM83G palmoplantar keratoderma mutations inhibit the PAWS1:CK1α association and attenuate Wnt signalling. [version 1; peer review: 2 approved]

Wellcome Open Research, 2019
Background: Two recessive mutations in the FAM83G gene, causing A34E and R52P amino acid substitutions in the DUF1669 domain of the PAWS1 protein, are associated with palmoplantar keratoderma (PPK) in humans and dogs respectively.
Kevin Z.L. Wu, Rebecca A. Jones, Theresa Tachie-Menson, Thomas J. Macartney, Nicola T. Wood, Joby Varghese, Robert Gourlay, Renata F. Soares, James C. Smith, Gopal P. Sapkota   +9 more
doaj   +1 more source

Multiple UBX proteins reduce the ubiquitin threshold of the mammalian p97-UFD1-NPL4 unfoldase

eLife, 2022
The p97/Cdc48 ATPase and its ubiquitin receptors Ufd1-Npl4 are essential to unfold ubiquitylated proteins in many areas of eukaryotic cell biology.
Ryo Fujisawa, Cristian Polo Rivera, Karim PM Labib   +2 more
doaj   +1 more source

Prevention and partial reversion of the lupus phenotype in ABIN1[D485N] mice by an IRAK4 inhibitor

Lupus Science and Medicine, 2021
Objective We have reported previously that the IRAK4 inhibitor PF06426779 given to ubiquitin-binding-defective ABIN1[D485N] mice at 6 weeks of age prevents the major facets of lupus that develop 10 weeks later.
Philip Cohen, Tsvetana Petrova, Sambit K Nanda, Cheryl Scudamore, Stephen W Wright, Vikram R Rao   +5 more
doaj   +1 more source

Finding Acceptable Parameter Regions of Stochastic Hill functions for Multisite Phosphorylation Mechanism [PDF]

The Journal of Chemical Physics 152.12 (2020): 124108, 2020
Multisite phosphorylation plays an important role in regulating switchlike protein activity and has been used widely in mathematical models. With the development of new experimental techniques and more molecular data, molecular phosphorylation processes emerge in many systems with increasing complexity and sizes.
arxiv   +1 more source

The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review)

International Journal of Molecular Medicine, 2017
Protein phosphorylation is an important cellular regulatory mechanism as many enzymes and receptors are activated/deactivated by phosphorylation and dephosphorylation events, by means of kinases and phosphatases.
F. Ardito, M. Giuliani, D. Perrone, G. Troiano, L. Muzio   +4 more
semanticscholar   +1 more source