Results 151 to 160 of about 340,222 (317)

Oral Dosed Organo‐Silica Nanoparticles Restore Glucose Homeostasis and β‐Cell Function in Diabetes Rats

Advanced Functional Materials, EarlyView.
An oral nanoplatform, MOP@T@D, which can maintain glucose homeostasis and restore islet β cells in diabetic rats is developed. It achieves efficient intestinal absorption and liver‐targeted delivery. The nanoparticle disintegrates only in response to hyperglycemia to release insulin on demand and provides antioxidant protection through selenoprotein ...
Chenxiao Chu, Mingli Wei, Che Bian, Xiaoshuang Bi, Yaxin Deng, Peifu Xiao, Jiansong Zhao, Yuying Wang, Haibing He, Jingxin Gou, Tian Yin, Xing Tang, Li Yang, Hongbo Zhang, Yu Zhang   +14 more
wiley   +1 more source

A conserved acidic residue drives thyroxine synthesis within thyroglobulin and other protein precursors. [PDF]

J Biol Chem
Stejskalova C, Arrigoni F, Albanesi R, Bertini L, Mollica L, Coscia F.   +5 more
europepmc   +1 more source

Spirocyclic β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: From Hit to Lowering of Cerebrospinal Fluid (CSF) Amyloid β in a Higher Species

, 2013
Kevin W. Hunt, Adam W. Cook, Ryan J. Watts, Christopher T. Clark, Guy Vigers, Darin Smith, Andrew T. Metcalf, Indrani W. Gunawardana, Michael Burkard, April Cox, Mary Geck, Darrin Dutcher, Allen A. Thomas, Sumeet Rana, Nicholas C. Kallan, Robert Kirk DeLisle, James P. Rizzi, Kelly Regal, Douglas M. Sammond, Robert D. Groneberg, Michael Siu, Hans E. Purkey, Joseph P. Lyssikatos, Allison Marlow, Xingrong Liu, Tony P. Tang   +25 more
openalex   +1 more source

The Major Structural Protein of African Swine Fever Virus, p73, Is Packaged into Large Structures, Indicative of Viral Capsid or Matrix Precursors, on the Endoplasmic Reticulum [PDF]

, 1998
Christian Cobbold, Thomas Wileman
openalex   +1 more source

DNA‐Templated 2D Heterostructures as Phototriggered Dynamic Nanohybrids: From Releasing Molecular Loads to Controlling Enzyme Biocatalytic Function

Advanced Functional Materials, EarlyView.
DNA strands are employed both as dynamic linkers and nanoscale templates for the integration of Ag2S nanoparticles on MoS2, which in turn imparted photothermal responsiveness; this feature permits the selective cargo (fluorophore, quantum dots or an enzyme) release from the MoS2 surface in response to local heat induced by light irradiation.
Kai Chen, Haosen Miao, Weiying Hong, Matteo Palma   +3 more
wiley   +1 more source

Pull the fuzes: Processing protein precursors to generate apoplastic danger signals for triggering plant immunity. [PDF]

Plant Commun
Del Corpo D, Coculo D, Greco M, De Lorenzo G, Lionetti V.   +4 more
europepmc   +1 more source

The beta-amyloid domain is essential for axonal sorting of amyloid precursor protein.

, 1996
P. J. Tienari, Bart De Strooper, Elina Ikonen, Mikael Simons, Andreas Weidemann, Christian Czech, Tobias Hartmann, N Ida, Gerd Multhaup, Colin L. Masters, F. Van Leuven, Konrad Beyreuther, Carlos G. Dotti   +12 more
openalex   +2 more sources

The Amyloid Precursor-like Protein 2 Associates with the Major Histocompatibility Complex Class I Molecule Kd [PDF]

, 2000
Martina Sester, Dominik Feuerbach, Rainer Frank, Tobias Preckel, Anja Gutermann, Hans-Gerhard Burgert   +5 more
openalex   +1 more source

A Single‐Metal‐Doped Nanoplatform for Ferroptosis‐Driven cGAS‐STING Pathway Activation in Hepatocellular Carcinoma Immunotherapy

Advanced Functional Materials, EarlyView.
The cGAS‐STING pathway boosts HCC antitumor immunity but lacks specific activation. Nanoplatform ZMRPF induces HCC ferroptosis via lipid ROS, releasing mtDNA. It synergizes with ZMRPF‐released Mn2⁺ to activate cGAS‐STING, amplifies antigen‐presenting cell activity, reverses HCC immunosuppression, and enables robust systemic antitumor immunity ...
Yuchen Zhang, Shuang Feng, Jie Luo, Kaige Xu, Junfeng Guo, Xingyue Zhang, Mengxue Yuan, Qiang Luo, Yu Huang, Chaoqiang Fan, Kibret Mequanint, Donghui Zhu, Malcolm Xing, Shiming Yang   +13 more
wiley   +1 more source

Racemic N1-Norphenserine and Its Enantiomers: Unpredicted Inhibition of Human Acetyl- and Butyrylcholinesterase and β-Amyloid Precursor Protein in vitro

, 2003
Nigel H. Greig, Qian‐sheng Yu, Weiming Luo, Harold W. Holloway, Tada Utsuki, Tracy Ann Perry, Debomoy K. Lahiri, Arnold Brossi   +7 more
openalex   +1 more source