Results 61 to 70 of about 322,759 (220)

Emerin anchors Msx1 and its protein partners at the nuclear periphery to inhibit myogenesis

Cell & Bioscience, 2019
Background Previous studies have shown that in myogenic precursors, the homeoprotein Msx1 and its protein partners, histone methyltransferases and repressive histone marks, tend to be enriched on target myogenic regulatory genes at the nuclear periphery.
Zhangjing Ma, Huiyuan Shi, Yi Shen, Huixia Li, Yu Yang, Jiange Yang, Hui Zhao, Gang Wang, Jingqiang Wang   +8 more
doaj   +1 more source

Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery

Nature Communications, 2021
Mitochondrial protein import is mediated by the translocase of the outer membrane (TOM), through which nearly all precursors traverse. Here, the authors perform global in vitro kinome profiling and by this identify that DYRK1A phosphorylates TOM70 and ...
Corvin Walter, Adinarayana Marada, Tamara Suhm, Ralf Ernsberger, Vera Muders, Cansu Kücükköse, Pablo Sánchez-Martín, Zehan Hu, Abhishek Aich, Stefan Loroch, Fiorella Andrea Solari, Daniel Poveda-Huertes, Alexandra Schwierzok, Henrike Pommerening, Stanka Matic, Jan Brix, Albert Sickmann, Claudine Kraft, Jörn Dengjel, Sven Dennerlein, Tilman Brummer, F.-Nora Vögtle, Chris Meisinger   +22 more
doaj   +1 more source

Membrane-protein interactions hold the key to understanding amyloid formation [PDF]

J. Phys. Chem. Letters 5, 633-635 (2014), 2014
In this perspective we describe the critical role membranes play in modulating the structures of the Amyloid Precursor Proteins to produce the peptides involved in the Alzheimer's disease. Some of the key concepts related to protein aggregation including the potential role of the excited states of monomers in initiating protein aggregation are ...
arxiv  

ELOVL4 protein preferentially elongates 20:5n3 to very long chain PUFAs over 20:4n6 and 22:6n3

Journal of Lipid Research, 2012
We hypothesized that reduction/loss of very long chain PUFAs (VLC-PUFAs) due to mutations in the ELOngase of very long chain fatty acid-4 (ELOVL4) protein contributes to retinal degeneration in autosomal dominant Stargardt-like macular dystrophy (STGD3 ...
Man Yu, Aaron Benham, Sreemathi Logan, R. Steven Brush, Md Nawajes A. Mandal, Robert E. Anderson, Martin-Paul Agbaga   +6 more
doaj  

Identification of Human Proteins vulnerable to multiple Organisms and their disease associations [PDF]

arXiv, 2016
While most studies emphasize on certain aspects of Pathogen-Host Interactions (PHI), such as the preferential attachment of bacteria or virus to its human receptor homolog, studies have attempted to methodically classify interactions among pathogenic proteins and their host proteins.
arxiv  

Characterization of antibacterial activity from protein hydrolysates of the macroalga Saccharina longicruris and identification of peptides implied in bioactivity

Journal of Functional Foods, 2015
The macroalga Saccharina longicruris proteins were extracted and hydrolysed with the enzyme trypsin in order to recover antibacterial peptides, which could be used in reducing food spoilage.
Lucie Beaulieu, Stéphanie Bondu, Kim Doiron, Laurie-Eve Rioux, Sylvie L. Turgeon   +4 more
doaj  

Interleukin-17 prevents oxidative stress from damaging osteoblast formation by inhibiting autophagic degradation of metallothionein-2

Endocrine Journal
Interleukin 17A (IL-17A) is a key cytokine promoting osteoblast formation, which contributes to osteogenesis. IL-17A functions in autophagy inhibition within osteoblasts.
Xueyan Ling, Cuixia Wang, Qin Feng, Tao Zhang   +3 more
doaj   +1 more source

Misregulation of ER-Golgi Vesicle Transport Induces ER Stress and Affects Seed Vigor and Stress Response

Frontiers in Plant Science, 2018
Seeds of higher plants accumulate numerous storage proteins to use as nitrogen resources for early plant development. Seed storage proteins (SSPs) are synthesized as large precursors on the rough endoplasmic reticulum (rER), and are delivered to protein ...
Xiaonan Zhao, Xiufen Guo, Xiaofei Tang, Xiaofei Tang, Hailong Zhang, Mingjing Wang, Yun Kong, Xiaomeng Zhang, Zhenjie Zhao, Min Lv, Lixin Li   +10 more
doaj   +1 more source

Machine Learning for Protein Function [PDF]

arXiv, 2016
Systematic identification of protein function is a key problem in current biology. Most traditional methods fail to identify functionally equivalent proteins if they lack similar sequences, structural data or extensive manual annotations. In this thesis, I focused on feature engineering and machine learning methods for identifying diverse classes of ...
arxiv  

Rat Dlx5 is expressed in the subventricular zone and promotes neuronal differentiation

Brazilian Journal of Medical and Biological Research, 2010
The molecular mechanisms and potential clinical applications of neural precursor cells have recently been the subject of intensive study. Dlx5, a homeobox transcription factor related to the distal-less gene in Drosophila, was shown to play an important ...
H.F. Shu, F.Y. Gao, C.Q. Zhang, S.Y. Liu, Z.Y. Zhang, Y.C. Song, K.J. Qiu, H. Yang   +7 more
doaj