Results 71 to 80 of about 322,759 (220)
A Cubic Equation of State for Amyloid Plaque Formation [PDF]
arXiv, 2013 Protein function depends on both protein structure and amino acid (aa) sequence. Here we show that modular features of both structure and function can be quantified from the aa sequence alone for the amyloid 770 aa precursor protein A4. Both the new second order hydropathicity scale, based on evolutionary optimization (self-organized criticality), and ...
arxiv
Self-assembling redox-wires form the 2D power grid of energy converting cell membranes [PDF]
arXiv, 2021 The light-driven reactions of photosynthesis, as well as the mitochondrial power supply, are hosted within specialized membranes containing a high fraction of redoxactive lipids. Protein mobility and diffusion of redox lipids is believed to be the in plane charge transfer mechanism along such cell membranes.
arxiv
Fractal Scaling of Cortical Matter, Amyloid Fragmentation and Plaque Formation across Rodents and Primates [PDF]
arXiv, 2014 Thermodynamic tools are well suited to connecting evolution of protein functionalities to mutations of amino acid sequences, especially for neuronal network structures. These tools enable one to quantify changes in modular structure and correlate them with corresponding changes in observable properties.
arxiv
Mathematical model for autoregulated miRNA biogenesis [PDF]
arXiv, 2020 MicroRNAs are small non-coding nucleotide sequences that regulate target protein expression at post-transcriptional levels. Biogenesis of microRNA is a highly regulated multi-step pathway. Regulation of miRNA biogenesis can be caused directly by the components of the biogenesis pathway or indirectly by other regulators.
arxiv
Protein and ionic surfactants - promoters and inhibitors of contact line pinning [PDF]
arXiv, 2007 We report a new effect of surfactants in pinning a drop contact line, specifically that lysozyme promotes while lauryl sulfate inhibits pinning. We explain the pinning disparity assuming difference in wetting: the protein-laden drop wets a "clean" surface and the surfactant-laden drop wets an auto-precursored surface.
arxiv
Journal of Experimental Neuroscience, 2018 Various regions of the developing brain coordinate their construction so that the correct types and numbers of cells are generated to build a functional network.
Anthony M Rossi, Vilaiwan M Fernandes
doaj +1 more source
Emergence of the protein universe in organismal evolution [PDF]
arXiv, 2006 In this work we propose a physical model of organismal evolution, where phenotype, organism life expectancy, is directly related to genotype i.e. the stability of its proteins which can be determined exactly in the model. Simulating the model on a computer, we consistently observe the Big Bang scenario whereby exponential population growth ensues as ...
arxiv
Precursor-mediated crystallization process in suspensions of hard spheres [PDF]
, 2010 We report on a large scale computer simulation study of crystal nucleation in hard spheres. Through a combined analysis of real and reciprocal space data, a picture of a two-step crystallization process is supported: First dense, amorphous clusters form which then act as precursors for the nucleation of well-ordered crystallites.
arxiv +1 more source
Processing of mitochondrial precursor proteins.
Biomedica biochimica acta, 1991 The mitochondrial processing enzyme consists of two components, the mitochondrial processing peptidase (MPP) and processing enhancing protein (PEP). MPP and PEP act cooperatively in proteolytic processing of mitochondrial precursor proteins. Most of the mitochondrial precursors possess aminoterminal presequences (also called "targeting sequences" or ...
Arretz, Michael +3 more
openaire +2 more sources
Protein Regge Trajectories, Phase Coexistence and Physics of Alzheimer's Disease [PDF]
arXiv, 2011 Alzheimer's disease causes severe neurodegeneration in the brain that leads to a certain death. The defining factor is the formation of extracellular senile amyloid plaques in the brain. However, therapeutic approaches to remove them have not been effective in humans, and so our understanding of the cause of Alzheimer's disease remains incomplete. Here
arxiv