Results 81 to 90 of about 750,523 (310)
Deciphering proteolytic processing of carbonic anhydrase 1 from Chlamydomonas reinhardtii [PDF]
, 2008 A Chlamydomonas gene CAH1 is responsible for the expression of the secreted protein periplasmic Carbonic Anhydrase 1 (CAH1), which undergoes unique post-translational processing.
Juvale, Parijat S.
core +3 more sources
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
RNA-processing protein TDP-43 regulates FOXO-dependent protein quality control in stress response. [PDF]
PLoS Genetics, 2014 Protein homeostasis is critical for cell survival and functions during stress and is regulated at both RNA and protein levels. However, how the cell integrates RNA-processing programs with post-translational protein quality control systems is unknown ...
Tao Zhang +3 more
doaj +1 more source
Expression of a human cartilage procollagen gene (COL2A1) in mouse 3T3 cells. [PDF]
, 1991 Expression in a recombinant system has been difficult to obtain for any of the major fibrillar collagens that require processing by eight or more post-translational enzymes.
Ala-Kokko, Leena +5 more
core +1 more source
An update on transcriptional and post-translational regulation of brain voltage-gated sodium channels [PDF]
, 2015 Voltage-gated sodium channels are essential proteins in brain physiology, as they generate the sodium currents that initiate neuronal action potentials.
Beltran-Alvarez, Pedro +1 more
core +1 more source
FEBS Letters, EarlyView.The S1025 peptide is the major antidote to the YrzI toxin, which we renamed here as SpyT (Small Peptide YrzI Toxin) and SpyA (Small Peptide YrzI Antitoxin) (1). Degradation of the toxin–antitoxin spyTA mRNA, either by a translation‐dependent cleavage by the endoribonuclease Rae1 (2) or by direct attack by 3′‐exoribonucleases (3), also contributes to ...
Laetitia Gilet +4 more
wiley +1 more source
Folding and Maturation of Tyrosinase-related Protein-1 Are Regulated by the Post-translational Formation of Disulfide Bonds and by N-Glycan Processing [PDF]
Journal of Biological Chemistry, 2000 In this study we have explored the endoplasmic reticulum associated events accompanying the maturation of the tyrosinase-related protein-1 (TRP-1) nascent chain synthesized in mouse melanoma cells. We show that TRP-1 folding process occurs much more rapidly than for tyrosinase, a highly homologous protein, being completed post-translationally by the ...
Stefana M. Petrescu +2 more
openaire +3 more sources
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Poly ADP-Ribosylation of Proteins
Journal of Biological Chemistry, 1989 The nuclear enzyme poly(ADP-ribose) polymerase (EC 2.4.2.30) participates in DNA excision repair by post-translational selfmodification ("automodification") and the modification of other chromatin proteins ("heteromodification") with ADP-ribose polymers.
Pius Loetscher +2 more
openaire +3 more sources
MicroRNA in control of gene expression: An overview of nuclear functions [PDF]
, 2016 The finding that small non-coding RNAs (ncRNAs) are able to control gene expression in a sequence specific manner has had a massive impact on biology. Recent improvements in high throughput sequencing and computational prediction methods have allowed the
Catalanotto, Caterina +2 more
core +2 more sources