Results 11 to 20 of about 1,538,071 (263)

Gene Signature Associated With Bromodomain Genes Predicts the Prognosis of Kidney Renal Clear Cell Carcinoma

Frontiers in Genetics, 2021
Bromodomain (BRD) proteins exhibit a variety of activities, such as histone modification, transcription factor recruitment, chromatin remodeling, and mediator or enhancer complex assembly, that affect transcription initiation and elongation.
Junwan Lu, Changrui Qian, Yongan Ji, Qiyu Bao, Bin Lu   +4 more
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SARS-CoV-2 mRNA-vaccine candidate; COReNAPCIN®, induces robust humoral and cellular immunity in mice and non-human primates

npj Vaccines, 2022
At the forefront of biopharmaceutical industry, the messenger RNA (mRNA) technology offers a flexible and scalable platform to address the urgent need for world-wide immunization in pandemic situations.
Reza Alimohammadi, Meysam Porgoo, Mohamad Eftekhary, Seyed Hossein Kiaie, Ehsan Ansari Dezfouli, Maryam Dehghani, Kaveh Nasrollahi, Talieh Malekshahabi, Maryam Heidari, Sedigheh Pouya, Masoumeh Alimohammadi, Dorsa Sattari Khavas, Mohammad Sadra Modaresi, Mohammad Hossein Ghasemi, Hamed Ramyar, Fatemeh Mohammadipour, Fateme Hamzelouei, Ahmadreza Mofayezi, Seyed Saeed Mottaghi, Amirhosein Rahmati, Mohsen Razzaznian, Vista Tirandazi, Mahdi Tat, Fatemeh Borzouee, Hossein Sadeghi, Melika Haji Mohammadi, Leila Rastegar, Seyed Milad Safar Sajadi, Hossein Ehsanbakhsh, Hamed Bazmbar, Zeinab Baghernejadan, Maedeh Shams Nouraei, Pouya Pazooki, Mina Pahlavanneshan, Khadijeh Alishah, Fateme Nasiri, Neda Mokhberian, Seyedeh Shima Mohammadi, Shima Akar, Hamidreza Niknam, Marzieh Azizi, Mohammad Ajoudanian, Mohammad Hossein Moteallehi-Ardakani, Seyed Ali Mousavi Shaegh, Reihaneh Ramezani, Vahid Salimi, Reza Moazzami, Seyed Mahmoud Hashemi, Somaye Dehghanizadeh, Vahid Khoddami   +49 more
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Ursolic Acid Targets Glucosyltransferase and Inhibits Its Activity to Prevent Streptococcus mutans Biofilm Formation

Frontiers in Microbiology, 2021
Streptococcus mutans (S. mutans), the prime pathogen of dental caries, can secrete glucosyltransferases (GTFs) to synthesize extracellular polysaccharides (EPSs), which are the virulence determinants of cariogenic biofilms.
Yucui Liu, Yucui Liu, Yanxin Huang, Cong Fan, Cong Fan, Zhongmei Chi, Miao Bai, Luguo Sun, Li Yang, Chunlei Yu, Zhenbo Song, Xiaoguang Yang, Xiaoguang Yang, Jingwen Yi, Jingwen Yi, Shuyue Wang, Lei Liu, Guannan Wang, Lihua Zheng   +18 more
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Characterization of the physicochemical changes and volatile compound fingerprinting during the chicken sugar-smoking process

Poultry Science, 2021
Sugar-smoking contributes to improving flavor attributes of meat products. However, there is rather limited information concerning the relationship between sugar-smoking process parameters and volatile compound (VC) fingerprinting as well as related ...
Hong Chang, Ying Wang, Qiang Xia, Daodong Pan, Jun He, Haimeng Zhang, Jinxuan Cao   +6 more
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USP28 enables oncogenic transformation of respiratory cells, and its inhibition potentiates molecular therapy targeting mutant EGFR, BRAF and PI3K

Molecular Oncology, 2022
Oncogenic transformation of lung epithelial cells is a multistep process, frequently starting with the inactivation of tumour suppressors and subsequent development of activating mutations in proto‐oncogenes, such as members of the PI3K or MAPK families.
Cristian Prieto‐Garcia, Oliver Hartmann, Michaela Reissland, Fabian Braun, Süleyman Bozkurt, Nikolett Pahor, Carmina Fuss, Andreas Schirbel, Christina Schülein‐Völk, Alexander Buchberger, Marco A. Calzado Canale, Mathias Rosenfeldt, Ivan Dikic, Christian Münch, Markus E. Diefenbacher   +14 more
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Effects of galactosyltransferase on EPS biosynthesis and freeze-drying resistance of Lactobacillus acidophilus NCFM

Food Chemistry: Molecular Sciences, 2022
Galactosyltransferase (GalT) is an important enzyme in synthesizing exopolysaccharide (EPS), the major polymer of biofilms protecting cells from severe conditions. However, the contribution to, and regulatory mechanism of GalT, in stressor resistance are
Lingyu Kong, Yuze Huang, Xiaoqun Zeng, Congyan Ye, Zhen Wu, Yuxing Guo, Daodong Pan   +6 more
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Ciclopirox and bortezomib synergistically inhibits glioblastoma multiforme growth via simultaneously enhancing JNK/p38 MAPK and NF-κB signaling

Cell Death and Disease, 2021
Ciclopirox (CPX) is an antifungal drug that has recently been reported to act as a potential anticancer drug. However, the effects and underlying molecular mechanisms of CPX on glioblastoma multiforme (GBM) remain unknown.
Zhipeng Su, Shengnan Han, Qiumei Jin, Ningning Zhou, Junwan Lu, Fugen Shangguan, Shiyi Yu, Yongzhang Liu, Lu Wang, Jianglong Lu, Qun Li, Lin Cai, Chengde Wang, Xiaohe Tian, Lingyan Chen, Weiming Zheng, Bin Lu   +16 more
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PMA-qPCR method for the selective quantitation of viable lactic acid bacteria in fermented milk

Frontiers in Microbiology, 2022
The number of viable lactic acid bacteria (LAB) is a key indicator of the quality of fermented milk. Currently, the combination of propidium monoazide (PMA) and qPCR has been applied in the quantification of viable bacteria in various matrices.
Zihang Shi, Zihang Shi, Xiefei Li, Xiefei Li, Xiankang Fan, Xiankang Fan, Jue Xu, Jue Xu, Qing Liu, Zhen Wu, Zhen Wu, Daodong Pan, Daodong Pan   +12 more
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Purification and Characterization of Novel Antioxidative Peptides From Duck Liver Protein Hydrolysate as Well as Their Cytoprotection Against Oxidative Stress in HepG2 Cells

Frontiers in Nutrition, 2022
This study aimed at mining antioxidant peptides derived from duck liver as a strategy for valorizing poultry byproducts utilization via the isolation and characterization of peptide molecules with great antioxidant potential and cytoprotective effects ...
Jin Sun, Changyu Zhou, Changyu Zhou, Jinxuan Cao, Jinxuan Cao, Jun He, Jun He, Yangying Sun, Yangying Sun, Yali Dang, Yali Dang, Daodong Pan, Daodong Pan, Daodong Pan, Qiang Xia, Qiang Xia   +15 more
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PTEN mutant non-small cell lung cancer require ATM to suppress pro-apoptotic signalling and evade radiotherapy

Cell & Bioscience, 2022
Background Despite advances in treatment of patients with non-small cell lung cancer, carriers of certain genetic alterations are prone to failure. One such factor frequently mutated, is the tumor suppressor PTEN.
Thomas Fischer, Oliver Hartmann, Michaela Reissland, Cristian Prieto-Garcia, Kevin Klann, Nikolett Pahor, Christina Schülein-Völk, Apoorva Baluapuri, Bülent Polat, Arya Abazari, Elena Gerhard-Hartmann, Hans-Georg Kopp, Frank Essmann, Mathias Rosenfeldt, Christian Münch, Michael Flentje, Markus E. Diefenbacher   +16 more
doaj   +1 more source