Results 11 to 20 of about 11,534,197 (263)

How do protein aggregates escape quality control in neurodegeneration? [PDF]

, 2022
Protein aggregates are hallmarks of neurodegenerative diseases. The protein quality control (PQC) system normally prevents proteins from misfolding and accumulation; however, proteins somehow escape this control on disease. Here we review advances in the
Ferrari, Luca, Rüdiger, Stefan G.D., Koopman, Margreet B.   +2 more
core   +3 more sources

Intramolecular quality control: HIV-1 envelope gp160 signal-peptide cleavage as a functional folding checkpoint [PDF]

, 2021
Removal of the membrane-tethering signal peptides that target secretory proteins to the endoplasmic reticulum is a prerequisite for proper folding.
Sub Cellular Protein Chemistry, Quandte, Matthias, Land, Aafke, McCaul, Nicholas, Sanders, Rogier W., Crooks, Ema T., Bontjer, Ilja, Binley, James M., van Zadelhoff, Guus, Braakman, Ineke, Cellular Protein Chemistry   +10 more
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Characterization of the physicochemical changes and volatile compound fingerprinting during the chicken sugar-smoking process

Poultry Science, 2021
Sugar-smoking contributes to improving flavor attributes of meat products. However, there is rather limited information concerning the relationship between sugar-smoking process parameters and volatile compound (VC) fingerprinting as well as related ...
Hong Chang, Ying Wang, Qiang Xia, Daodong Pan, Jun He, Haimeng Zhang, Jinxuan Cao   +6 more
doaj   +1 more source

USP28 enables oncogenic transformation of respiratory cells, and its inhibition potentiates molecular therapy targeting mutant EGFR, BRAF and PI3K

Molecular Oncology, 2022
Oncogenic transformation of lung epithelial cells is a multistep process, frequently starting with the inactivation of tumour suppressors and subsequent development of activating mutations in proto‐oncogenes, such as members of the PI3K or MAPK families.
Cristian Prieto‐Garcia, Oliver Hartmann, Michaela Reissland, Fabian Braun, Süleyman Bozkurt, Nikolett Pahor, Carmina Fuss, Andreas Schirbel, Christina Schülein‐Völk, Alexander Buchberger, Marco A. Calzado Canale, Mathias Rosenfeldt, Ivan Dikic, Christian Münch, Markus E. Diefenbacher   +14 more
doaj   +1 more source

Effects of galactosyltransferase on EPS biosynthesis and freeze-drying resistance of Lactobacillus acidophilus NCFM

Food Chemistry: Molecular Sciences, 2022
Galactosyltransferase (GalT) is an important enzyme in synthesizing exopolysaccharide (EPS), the major polymer of biofilms protecting cells from severe conditions. However, the contribution to, and regulatory mechanism of GalT, in stressor resistance are
Lingyu Kong, Yuze Huang, Xiaoqun Zeng, Congyan Ye, Zhen Wu, Yuxing Guo, Daodong Pan   +6 more
doaj   +1 more source

Ciclopirox and bortezomib synergistically inhibits glioblastoma multiforme growth via simultaneously enhancing JNK/p38 MAPK and NF-κB signaling

Cell Death and Disease, 2021
Ciclopirox (CPX) is an antifungal drug that has recently been reported to act as a potential anticancer drug. However, the effects and underlying molecular mechanisms of CPX on glioblastoma multiforme (GBM) remain unknown.
Zhipeng Su, Shengnan Han, Qiumei Jin, Ningning Zhou, Junwan Lu, Fugen Shangguan, Shiyi Yu, Yongzhang Liu, Lu Wang, Jianglong Lu, Qun Li, Lin Cai, Chengde Wang, Xiaohe Tian, Lingyan Chen, Weiming Zheng, Bin Lu   +16 more
doaj   +1 more source

PMA-qPCR method for the selective quantitation of viable lactic acid bacteria in fermented milk

Frontiers in Microbiology, 2022
The number of viable lactic acid bacteria (LAB) is a key indicator of the quality of fermented milk. Currently, the combination of propidium monoazide (PMA) and qPCR has been applied in the quantification of viable bacteria in various matrices.
Zihang Shi, Zihang Shi, Xiefei Li, Xiefei Li, Xiankang Fan, Xiankang Fan, Jue Xu, Jue Xu, Qing Liu, Zhen Wu, Zhen Wu, Daodong Pan, Daodong Pan   +12 more
doaj   +1 more source

Studying protein-protein interactions using peptide arrays [PDF]

, 2010
Screening of arrays and libraries of compounds is well-established as a high-throughput method for detecting and analyzing interactions in both biological and chemical systems. Arrays and libraries can be composed from various types of molecules, ranging
Rito, T., Rudiger, S.G.D., Sub Cellular Protein Chemistry, Rotem-Bamberger, S., Katz, C., Friedler, A., Levy-Beladev, L., Cellular Protein Chemistry   +7 more
core   +1 more source

Combining high‐protein ingredients from pseudocereals and legumes for the development of fresh high‐protein hybrid pasta: maintained technological quality and adequate sensory attributes [PDF]

, 2022
49774987BACKGROUND: The fortification of cereal foods, like pasta, with pseudocereal and legume ingredients promises a substantial improvement of their nutritional quality.
Jürgen Bez, Andrea Hoehnel, Emanuele Zannini, Elke K. Arendt, Bez, Jürgen, Ryszard Amarowicz, Hoehnel, Andrea, Arendt, Elke Karin, Amarowicz, Ryszard, Zannini, Emanuele   +9 more
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Purification and Characterization of Novel Antioxidative Peptides From Duck Liver Protein Hydrolysate as Well as Their Cytoprotection Against Oxidative Stress in HepG2 Cells

Frontiers in Nutrition, 2022
This study aimed at mining antioxidant peptides derived from duck liver as a strategy for valorizing poultry byproducts utilization via the isolation and characterization of peptide molecules with great antioxidant potential and cytoprotective effects ...
Jin Sun, Changyu Zhou, Changyu Zhou, Jinxuan Cao, Jinxuan Cao, Jun He, Jun He, Yangying Sun, Yangying Sun, Yali Dang, Yali Dang, Daodong Pan, Daodong Pan, Daodong Pan, Qiang Xia, Qiang Xia   +15 more
doaj   +1 more source