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Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

Population-Scale Studies of Protein S Abnormalities and Thrombosis.

open access: yesJAMA
Chaudhry SA   +11 more
europepmc   +1 more source
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Protein S mRNA in Patients with Protein S Deficiency

Thrombosis and Haemostasis, 1995
SummaryA protein S gene polymorphism, detectable by restriction analysis (BstXI) of amplified exonic sequences (exon 15), was studied in seven Italian families with protein S deficiency. In the 17 individuals heterozygous for the polymorphism the study was extended to platelet mRNA through reverse transcription, amplification and densitometric analysis.
SACCHI E   +6 more
openaire   +2 more sources

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