Results 71 to 80 of about 1,074,296 (345)
Loss of ATF3 exacerbates liver damage through the activation of mTOR/p70S6K/ HIF-1α signaling pathway in liver inflammatory injury. [PDF]
, 2018 Activating transcription factor 3 (ATF3) is a stress-induced transcription factor that plays important roles in regulating immune and metabolic homeostasis.
Jiang, Bin +9 more
core +2 more sources
An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots
FEBS Letters, EarlyView.This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino +7 more
wiley +1 more source
, 2008 血栓性素因とは血栓症を発症しやすい体質のことである。欧米白人種の血栓性素因は、凝固系第五因子の１箇所の変異（Factor V Leiden（R５０６Q））であることが１０年余り前に判明し、欧米白人に対する血栓症対策は急速に進歩した。しかしながら、黒人やアジア人など欧米白人以外の人種では、Factor V Leiden（R５０６Q）を保因している人は皆無であり、これらの人種での血栓性素因の解明がいそがれていた。我々は日本人ならびにアジア人における血栓性素因の解明を目指して研究を行ってきた。その結果 ...
Naotaka HAMASAKI, 濱崎 直孝
core +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Protein C and protein S deficiency associated cerebral venous thrombosis: one case report
Chinese Journal of Contemporary Neurology and NeurosurgeryObjective To report one case with protein C deficiency (PCD) and protein S deficiency (PSD) associated cerebral venous thrombosis (CVT), and to explore diagnostic and therapeutic strategies.
HUANG Zhan +5 more
doaj +1 more source
Thrombosis Journal, 2021 Background Protein S deficiency (PSD) is an autosomal dominant hereditary disease. In 1984, familial PSD was reported to be prone to recurrent thrombosis.
Yan-ping Zhang +12 more
doaj +1 more source
Molecular basis of protein S deficiency
Thrombosis and Haemostasis, 2007 SummaryProtein S deficiency (PSD) has been the most difficult to study among the classical inherited thrombophilic factors. This is in part due to the peculiar biology of protein S (PS), which has an anticoagulant role but no enzymatic activity,and because it interacts with plasma components that function in both haemostasis and inflammation.Clinically,
García de Frutos, Pablo +3 more
openaire +3 more sources
Hmga2 is dispensable for pancreatic cancer development, metastasis, and therapy resistance. [PDF]
, 2018 Expression of the chromatin-associated protein HMGA2 correlates with progression, metastasis and therapy resistance in pancreatic ductal adenocarcinoma (PDAC). Hmga2 has also been identified as a marker of a transient subpopulation of PDAC cells that has
Chiou, Shin-Heng +7 more
core +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Testicular infarction secondary to protein S deficiency: a case report
BMC Urology, 2006 Background Protein S deficiency is an inherited cause of thrombophilia. We present the second reported case in the literature of a man developing testicular infarction secondary to protein S deficiency.
Marron Conor, McKay Damian, Brown Robin
doaj +1 more source