Results 81 to 90 of about 15,453 (247)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Bilateral simultaneous central retinal vein occlusion in protein S deficiency

, 2015
Case report: This article reports a case of bilateral simultaneous central retinal vein occlusion (CRVO) and protein S deficiency. The 27-year-old male patient presented with a sudden decrease in vision in both eyes.
Reichel C,, Ecsedy, Mónika, Nagy, Zoltán Zsolt, Domján, Gyula, Tóth, Gábor, Sándor, Gábor László   +5 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Cerebral Venous Thrombosis and Acute Pulmonary Embolism following Varicella Infection

European Journal of Case Reports in Internal Medicine, 2019
Varicella infection is caused by varicella-zoster virus (VZV) and commonly presents as a self-limiting skin manifestation in children. VZV also causes cerebral arterial vasculopathy and antibody-mediated hypercoagulable states leading to thrombotic ...
Rashid Khan, Yasmeen Ajaz, Anoop Kumar Pandey, Khalid AlSaffar, Sunil Roy Thottuvelil Narayanan   +4 more
doaj   +1 more source

Anticoagulant Treatment with Rivaroxaban in Severe Protein S Deficiency

, 2013
We report a case of a 6-year-old girl with severe protein S deficiency due to a homozygous mutation and recurrent episodes of skin necrosis. She developed purpura fulminans at birth and a catheter-related venous thrombosis complicated by massive ...
S. M. Passamonti, P. Bucciarelli, E. Fossali, A. Tripodi, I. Martinelli, A. Artoni, F. Peyvandi   +6 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

SERPINA1 PiZ and PiS heterozygotes and lung function decline in the SAPALDIA cohort [PDF]

, 2012
BACKGROUND: Severe alpha1-antitrypsin (AAT) deficiency is a strong risk factor for COPD. But the impact of gene variants resulting in mild or intermediate AAT deficiency on the longitudinal course of respiratory health remains controversial.
Margaret Gerbase, Nicole M Probst-Hensch, Zorzetto Michele, Zorzetto, M., F. Kronenberg, P. Bridevaux, Ottaviani, S., LUISETTI, MAURIZIO, Zemp, E., N. M. Probst Hensch, Elisabeth Zemp (142900), Erich W Russi, Gian-Andri Thun (142891), Gerbase Margaret, Russi Erich W., Gian-Andri Thun, Thierry Rochat, E. Zemp, FERRAROTTI, ILARIA, Florian Kronenberg (87557), Maurizio Luisetti (142908), G. Thun, Nicole M. Probst-Hensch (110284), Michele Zorzetto (142902), Russi, E. W., Medea Imboden, Stefania Ottaviani, Ilaria Ferrarotti (142893), Pierre-Olivier Bridevaux, Kronenberg Florian, Florian Kronenberg, Ferrarotti, I., Bridevaux Pierre-Olivier, Luisetti Maurizio, S. Ottaviani, Erich W. Russi (142906), Ferrarotti Ilaria, Stefania Ottaviani (142904), Thun Gian-Andri, Michele Zorzetto, E. W. Russi, Gerbase, M., Bridevaux, P. O., Pierre-Olivier Bridevaux (142898), Rochat, T., T. Rochat, Thierry Rochat (110261), Thun, G. A., M. Gerbase, Ilaria Ferrarotti, Margaret Gerbase (142896), Elisabeth Zemp, Maurizio Luisetti, Imboden, M., Medea Imboden (110145), Imboden Medea, M. Zorzetto, Rochat Thierry, Kronenberg, F., Probst-Hensch, N. M., M. Imboden, Probst-Hensch Nicole M., Luisetti, M., Ottaviani Stefania, Zemp Elisabeth   +64 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Tense Ascites as a Presentaton of Protein S Defciency in a 9-Year-Old Boy

Case Reports in Clinical Practice, 2019
Ascites is not a usual finding in prehepatic portal hypertension, including portal vein thrombosis, but when portal vein thrombosis is acute and massive, ascites can be a presenting feature.
Masoumeh Asgarshirazi, Mehrnoush Ghafarypour, Yahya Aghighi, Seyyedreza Raeeskarami, Mehri Najafi   +4 more
doaj   +1 more source