Results 81 to 90 of about 24,775,971 (291)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Free protein S deficiency in acute ischemic stroke. A case-control study.

, 1993
Deficiency of free protein S, a naturally occurring anticoagulant, may be acquired in the setting of acute illness and increasingly has become recognized as a possible stroke risk factor.
Shi, T, Sacco, R L, Mohr, J P, S A Mayer, A Hurlet-Jensen, T Shi, Mayer, S A, Hurlet-Jensen, A, R L Sacco, J P Mohr   +9 more
core   +1 more source

Cerebral Venous Thrombosis and Acute Pulmonary Embolism following Varicella Infection

European Journal of Case Reports in Internal Medicine, 2019
Varicella infection is caused by varicella-zoster virus (VZV) and commonly presents as a self-limiting skin manifestation in children. VZV also causes cerebral arterial vasculopathy and antibody-mediated hypercoagulable states leading to thrombotic ...
Rashid Khan, Yasmeen Ajaz, Anoop Kumar Pandey, Khalid AlSaffar, Sunil Roy Thottuvelil Narayanan   +4 more
doaj   +1 more source

Tau protein, A beta 42 and S-100B protein in cerebrospinal fluid of patients with dementia with Lewy bodies [PDF]

, 2005
The intra vitam diagnosis of dementia with Lewy bodies (DLB) is still based on clinical grounds. So far no technical investigations have been available to support this diagnosis.
Cepek, L., Neumann, M., Ciesielczyk, Barbara, Cepek, Lukas, Neumann, Manuela, Trenkwalder, C., Kretzschmar, Hans A., Otto, M., Mollenhauer, B., Schulz-Schaeffer, W. J., Poser, Sigrid, Otto, Markus, Ciesielczyk, B., Steinacker, Petra, Steinacker, P., Wiltfang, J., Schulz-Schaeffer, Walter J., Poser, S., Bibl, Mirko, Mollenhauer, Brit, Trenkwalder, Claudia, Bibl, M., Wiltfang, Jens, Kretzschmar, H. A.   +23 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Severe congenital protein C deficiency: the use of protein C concentrates (human) as replacement therapy for life-threatening blood-clotting complications

, 2008
Paul N KnoeblDepartment of Medicine 1, Division Hematology and Hemostasis, Medical University of Vienna, Vienna, AustriaAbstract: The protein C pathway has an important function in regulating and modulating blood coagulation and ensuring patency of the ...
Paul N Knoebl
core  

Deficiency of plasma protein S, protein C, or antithrombin III and arterial thrombosis.

, 1987
Protein C and protein S are vitamin K-dependent coagulation factors that together act as an anticoagulant, and antithrombin III is a plasma protein that inhibits several activated factors in the coagulation cascade.
P C Comp, J Owen, D Horowitz, B S Coller, J Jesty, J Spear, M J Reitman, T Yeh   +7 more
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Free protein S deficiency: a possible association with cerebrovascular occlusion.

, 1989
A deficiency of free protein S, known to increase the risk of peripheral venous thrombosis, has not been well described in patients with cerebrovascular disease.
SACCO, R. L, B A Grossman, OWEN, J, J Owen, R L Sacco, TATEMICHI, T. K, GROSSMAN, B. A, J P Mohr, MOHR, J. P, T K Tatemichi   +9 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source