Results 91 to 100 of about 24,775,971 (291)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

The Frequency of Heterozygous Protein C Deficiency and Heterozygous Protein S Deficiency in Both Normal and Cerebral Thrombotic Conditions [PDF]

Protein C and protein S activities were assayed in 508 healthy subjects and in 121 patients with cerebral thrombosis, and the frequencies of the congenital deficiencies of these physiological anticoagulant proteins were examined. In the healthy subjects,
Endo, Takeshi, Tamura, Kohji, Kobayashi, Isao, Kurihara, Atsushi, 53430, 53433, Ozawa, Hideyuki, 53434, 53431, Yazaki, Akihiko, 53432, Amemiya, Norihiko, 53437, Kume, Shoji, 53435, 53436, Hamaoka, Satomi, 53428, Mizoe, Asako, 53429   +19 more
core   +1 more source

Central retinal vein prethrombosis as an initial manifestation of protein S deficiency

São Paulo Medical Journal
CONTEXT: Retinal vein thrombosis is most common in old people, and is often associated with systemic vascular disease. One of its rare systemic causes is protein S deficiency.
Paulo de Tarso Ponte Pierre-Filho, Alessandra Maria Mont'Alverne Pierre, Maurício Abujamra Nascimento, Ana Maria Marcondes   +3 more
doaj   +1 more source

Tense Ascites as a Presentaton of Protein S Defciency in a 9-Year-Old Boy

Case Reports in Clinical Practice, 2019
Ascites is not a usual finding in prehepatic portal hypertension, including portal vein thrombosis, but when portal vein thrombosis is acute and massive, ascites can be a presenting feature.
Masoumeh Asgarshirazi, Mehrnoush Ghafarypour, Yahya Aghighi, Seyyedreza Raeeskarami, Mehri Najafi   +4 more
doaj   +1 more source

Protein-RNA interactions: a structural analysis [PDF]

, 2001
A detailed computational analysis of 32 protein-RNA complexes is presented. A number of physical and chemical properties of the intermolecular interfaces are calculated and compared with those observed in protein-double-stranded DNA and protein-single ...
Daley, DT, Berman, HM, Luscombe, NM, Helen M Berman (10123868), Susan Jones (4079), Thornton, JM, David T A Daley (16115222), Janet M Thornton (16060073), Jones, S, Nicholas M Luscombe (8114756)   +9 more
core  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Nitric oxide and glutathione impact the expression of iron uptake- and iron transport-related genes as well as the content of metals in A. thaliana plants grown under iron deficiency [PDF]

, 2012
Mounting evidence indicate that nitric oxide (NO) acts as a signaling molecule mediating iron deficiency responses through the up-regulation of the expression of iron uptake-related genes.
Dobrowolska, Grażyna, Szymańska, K
core   +1 more source

Study of a protein S gene polymorphism at DNA and mRNA level in a family with symptomatic protein S deficiency

, 1993
A protein S gene polymorphism, detectable by restriction analysis of amplified exonic sequences, was investigated in a family with members affected by protein S deficiency, deep vein thrombosis and ictus.
LEGNANI C, COCCHERI S, MARCHETTI, Giovanna, BERNARDI, Francesco, PALARETI G, PATRACCHINI P, FERRATI M, GEMMATI, Donato   +7 more
core  

Protein S Deficiency and an Adult Case with Moyamoya Syndrome that Presented with Primary Intraventricular Haemorrhage

Balkan Medical Journal, 2014
Background: Moyamoya syndrome associated with protein S deficiency is rarely encountered and is usually reported in paediatric cases with cerebral ischaemia.
Betül Çevik, Semiha Kurt, Durdane Aksoy, Berat Acu   +3 more
doaj   +1 more source