Results 71 to 80 of about 15,453 (247)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Deficiency of plasma protein S, protein C, or antithrombin III and arterial thrombosis.

, 1987
Protein C and protein S are vitamin K-dependent coagulation factors that together act as an anticoagulant, and antithrombin III is a plasma protein that inhibits several activated factors in the coagulation cascade.
P C Comp, J Owen, D Horowitz, B S Coller, J Jesty, J Spear, M J Reitman, T Yeh   +7 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Free protein S deficiency: a possible association with cerebrovascular occlusion.

, 1989
A deficiency of free protein S, known to increase the risk of peripheral venous thrombosis, has not been well described in patients with cerebrovascular disease.
SACCO, R. L, B A Grossman, OWEN, J, J Owen, R L Sacco, TATEMICHI, T. K, GROSSMAN, B. A, J P Mohr, MOHR, J. P, T K Tatemichi   +9 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Livedoid vasculopathy in protein S deficiency

Pan African Medical Journal
A 38-year-old female patient presented to the General Medicine Outpatient Department (OPD) with chief complaints of multiple ulcerations associated with pain over the bilateral lower limbs which was present for 1 month. The patient had initially taken only symptomatic treatment with a topical steroid preparation prescribed by a general practitioner but
Hemant Juneja, Gaurang Aurangabadkar
openaire   +3 more sources

Weight status and iron deficiency among urban Malian women of reproductive age

, 2011
The present study investigated the association between weight status and Fe deficiency (ID) among urban Malian women of reproductive age. Height, weight, serum ferritin (SF), soluble transferrin receptor (sTfR) and C-reactive protein (CRP) concentrations
Brouwer, I.D., Saronga, N.J., Fanou-Fogny, N.M.L., Koreissi, Y., Boonstra, A., Dossa, R.A.M.   +5 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A rare case of autoimmune hemolytic anemia with protein S deficiency with splenic infarct

Asian Journal of Transfusion Science
Splenic infarction is a rare entity in pediatric population and is associated with predisposing conditions, i.e., hematological and oncological or infections.
Afreen Khan, Twisha Ishani, Ishaq Farooq, Devki Nandan, Shohrab Alam   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source