Results 111 to 120 of about 2,642,890 (372)
Molecular Oncology, EarlyView.Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser +14 more
wiley +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
, 2015 We inquire how structure emerges during the process of protein folding. For this we scrutinise col- lective many-atom motions during all-atom molecular dynamics simulations.
Dai, Jin +4 more
core +1 more source
Prediction of Protein Secondary Structure With Clonal Selection Algorithm and Multilayer Perceptron
IEEE Access, 2018 The recent studies indicate that the protein secondary structure provides very important advantages in determining the function of a protein, treating numerous diseases and drug design. Determining the secondary structure in the laboratory environment is
Burcu Çarklı Yavuz +2 more
semanticscholar +1 more source
Combining classifiers for protein secondary structure prediction
2017 9th International Conference on Computational Intelligence and Communication Networks (CICN), 2017 Protein secondary structure prediction is an important step in estimating the three dimensional structure of proteins. Among the many methods developed for predicting structural properties of proteins, hybrid classifiers and ensembles that combine predictions from several models are shown to improve the accuracy rates. In this paper, we train, optimize
Aydin, Zafer, Uzut, Ommu Gulsum
openaire +3 more sources
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Sixty-five years of the long march in protein secondary structure prediction: the final stretch?
Briefings Bioinform., 2016 Protein secondary structure prediction began in 1951 when Pauling and Corey predicted helical and sheet conformations for protein polypeptide backbone even before the first protein structure was determined.
Yuedong Yang +6 more
semanticscholar +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source