Results 91 to 100 of about 5,630,720 (303)

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

CaMKIIalpha interacts with multi-PDZ domain protein MUPP1 in spermatozoa and prevents spontaneous acrosomal exocytosis [PDF]

, 2009
The success of acrosomal exocytosis, a complex process with a variety of inter-related steps, relies on the coordinated interaction of participating signaling molecules.
Borth, Heike, Boekhoff, Ingrid, Ackermann, Frauke, Zitranski, Nele, Gudermann, Thomas, Buech, Thomas   +5 more
core   +1 more source

A Novel Glycoproteomics Workflow Reveals Dynamic O-GlcNAcylation of COPγ1 as a Candidate Regulator of Protein Trafficking

Frontiers in Endocrinology, 2018
O-linked β-N-acetylglucosamine (O-GlcNAc) is an abundant and essential intracellular form of protein glycosylation in animals and plants. In humans, dysregulation of O-GlcNAcylation occurs in a wide range of diseases, including cancer, diabetes, and ...
Nathan J. Cox, Peter M. Luo, Timothy J. Smith, Brittany J. Bisnett, Erik J. Soderblom, Michael Boyce   +5 more
doaj   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Endothelial cells modulate renin secretion from isolated mouse juxtaglomerular cells [PDF]

, 1991
Utilizing cocultures of mouse renal juxtaglomerular cells with bovine microvascular endothelial cells, we have examined whether endothelial cells exert direct influence on renin secretion from renal juxtaglomerular cells.
Kaissling, Brigitte, Kurtz, Armin, Baier, Wolfgang, W Baier, R Busse, A Kurtz, Busse, Rudi, B Kaissling   +7 more
core   +1 more source

workshop EMBO "Molecular mechanisms of unconventional protein secretion in eukaryotic cells"

, 2019
The trafficking of proteins to the extracellular space and the plasma membrane is known to be mediated by the endoplasmic reticulum to Golgi classical secretory pathway.
Chiara Zurzolo, Catherine Rabouille, Michele Bellucci, Andrea Pompa, Vivek Malhotra, Maria Teresa Pallotta, Walter Nickel, Fracesca De Marchis   +7 more
core   +1 more source

Structural Basis of the Subcellular Topology Landscape of Escherichia coli

Frontiers in Microbiology, 2019
Cellular proteomes are distributed in multiple compartments: on DNA, ribosomes, on and inside membranes, or they become secreted. Structural properties that allow polypeptides to occupy subcellular niches, particularly to after crossing membranes, remain
Maria S. Loos, Reshmi Ramakrishnan, Reshmi Ramakrishnan, Wim Vranken, Wim Vranken, Alexandra Tsirigotaki, Evrydiki-Pandora Tsare, Valentina Zorzini, Jozefien De Geyter, Biao Yuan, Ioannis Tsamardinos, Ioannis Tsamardinos, Maria Klappa, Joost Schymkowitz, Frederic Rousseau, Spyridoula Karamanou, Anastassios Economou, Anastassios Economou   +17 more
doaj   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease

FEBS Letters, EarlyView.
Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim, Thi Thanh Mai Tran, Nakyung Kang, Min‐Woo Lee, Mihye Lee   +4 more
wiley   +1 more source

Quantification of Protein Secretion from Circulating Tumor Cells in Microfluidic Chambers

Advanced Science, 2020
Cancer cells can be released from a cancerous lesion and migrate into the circulatory system, from whereon they may form metastases at distant sites. Today, it is possible to infer cancer progression and treatment efficacy by determining the number of ...
Lucas Armbrecht, Ophélie Rutschmann, Barbara Maria Szczerba, Jonas Nikoloff, Nicola Aceto, Petra S. Dittrich   +5 more
doaj   +1 more source