Results 101 to 110 of about 4,543,051 (305)

Effect of montelukast on platelet activating factor- and tachykinin induced mucus secretion in the rat [PDF]

, 2008
Background: Platelet activating factor and tachykinins (substance P, neurokinin A, neurokinin B) are important mediators contributing to increased airway secretion in the context of different types of respiratory diseases including acute and chronic ...
David A Groneberg, Groneberg, David A., Wagner, Ulrich, Groneberg, Jan David Alexander, Groneberg David A, Staats Petra, Schmidt Rene, Ulrich Wagner, Schmidt, Rene, Petra Staats, Staats, Petra, Rene Schmidt, Wagner Ulrich   +12 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

The ArfGEF GBF-1 Is Required for ER Structure, Secretion and Endocytic Transport in C. elegans [PDF]

, 2013
Small GTPases of the Sar/Arf family are essential to generate transport containers that mediate communication between organelles of the secretory pathway.
Anne Spang, Ackema, K. B., Jachen A Solinger, Karin B Ackema, Ursula Sauder, Solinger, J. A., Karin B. Ackema, Jachen A. Solinger (254344), Jachen A. Solinger, Karin B. Ackema (423507), Ursula Sauder (250540), Spang, A., Anne Spang (205738), Sauder, U.   +13 more
core   +2 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Dimeric structure of the bacterial extracellular foldase PrsA [PDF]

, 2015
Secretion of proteins into the membrane-cell wall space is essential for cell wall biosynthesis and pathogenicity in Gram-positive bacteria. Folding and maturation of many secreted proteins depend on a single extracellular foldase, the PrsA protein. PrsA
Schmidpeter, Philipp A. M., Hiller, Sebastian, Schmid, Franz X., Hunkeler, Moritz, Burmann, Björn M., Maier, Timm, Jakob, Roman P., Koch, Johanna R.   +7 more
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Global transcriptional profiling of Burkholderia pseudomallei under salt stress reveals differential effects on the Bsa type III secretion system. [PDF]

, 2010
BACKGROUND: Burkholderia pseudomallei is the causative agent of melioidosis where the highest reported incidence world wide is in the Northeast of Thailand, where saline soil and water are prevalent.
Stabler, Richard A., Sunee Korbsrisate, Stevens, Mark P, Pornpan Pumirat, Ekapot Singsuksawat, Wren, Brendan W, Korbsrisate, Sunee, Singsuksawat, Ekapot, Mark P Stevens, Muangsombut, Veerachat, Veerachat Muangsombut, Cuccui, Jon, Richard A Stabler, Joanne M Stevens, Pumirat, Pornpan, Wren, Brendan W., Stabler, Richard A, Stevens, Joanne M, Stevens, Joanne M.; id_orcid, Stevens, Mark P., Jon Cuccui, Brendan W Wren, Singsuksawat Ekapot, Stevens Mark P, Cuccui Jon, Stabler Richard A, Stevens Joanne M, Korbsrisate Sunee, Wren Brendan W, Muangsombut Veerachat, Pumirat Pornpan   +30 more
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Established microbial colonies can survive type VI secretion assault [PDF]

, 2015
Type VI secretion (T6S) is a cell-to-cell injection system that can be used as a microbial weapon. T6S kills vulnerable cells, and is present in close to 25% of sequenced Gram-negative bacteria.
Ned S Wingreen, Marek Basler (173162), Basler, Marek, Ringel, Peter, David Bruce Borenstein, Peter Ringel (816293), Borenstein, David Bruce, Peter Ringel, Wingreen, Ned S., Wingreen, Ned, Marek Basler, David Bruce Borenstein (413437), Ned S. Wingreen (10926)   +12 more
core   +2 more sources

Apolipoprotein M expression increases the size of nascent preβ HDL formed by ATP binding cassette transporter A1

Journal of Lipid Research, 2010
Apolipoprotein M (apoM) is a novel apolipoprotein that is reportedly necessary for preβ HDL formation; however, its detailed function remains unknown. We investigated the biogenesis and properties of apoM and its effects on the initial steps of nascent ...
Anny Mulya, Jeongmin Seo, Amanda L. Brown, Abraham K. Gebre, Elena Boudyguina, Gregory S. Shelness, John S. Parks   +6 more
doaj   +1 more source