Results 191 to 200 of about 3,139,545 (345)

All-atom protein sequence design using discrete diffusion models. [PDF]

J Cheminform
Villegas-Morcillo A, Admiraal GJ, Reinders MJT, Weber JM.   +3 more
europepmc   +1 more source

Additional file 3 of FINDER: an automated software package to annotate eukaryotic genes from RNA-Seq data and associated protein sequences

, 2021
Sagnik Banerjee, Priyanka Bhandary, Margaret Woodhouse, Taner Z. Sen, Roger P. Wise, Carson M. Andorf   +5 more
openalex   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

AllergenAI: a deep learning model predicting allergenicity based on protein sequence. [PDF]

BMC Bioinformatics
Liu J, Negi SS, Yang C, Zhou X, Schein CH, Braun W, Kim P.   +6 more
europepmc   +1 more source

Flexibility in MuA Transposase Family Protein Structures: Functional Mapping with Scanning Mutagenesis and Sequence Alignment of Protein Homologues

, 2012
Tiina Rasila, Mauno Vihinen, Lars Paulín, Saija Haapa-Paananen, Harri Savilahti   +4 more
openalex   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Signal-strapping as a protein-sequence search method for the discovery of metalloproteins. [PDF]

Nat Commun
Franco Cairo JPL, Corrêa TLR, Offen WA, Nairn AK, Walton J, Sweeney ST, Davies GJ, Walton PH.   +7 more
europepmc   +1 more source

Long‐ and short‐range interactions in native protein structures are consistent/minimally frustrated in sequence space

, 2002
Sanzo Miyazawa, Robert L. Jernigan
openalex   +2 more sources

Accurate prediction of transmembrane β -barrel proteins from sequences [PDF]

, 2014
Sikander Hayat, Chris Sander, Arne Elofsson, Debora S. Marks   +3 more
openalex   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source