Results 251 to 260 of about 3,139,545 (345)

Characterizing protein sequence determinants of nuclear condensates by high-throughput pooled imaging with CondenSeq. [PDF]

Nat Methods
Kappel K, Strebinger D, Edmonds KK, Chau-Duy-Tam Vo S, Vockley CM, Biswas T, Farhi SL, Macrae R, Zhang F, Regev A.   +9 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Pareto-optimal sampling for multi-objective protein sequence design. [PDF]

iScience
Luo J, Ding K, Luo Y.
europepmc   +1 more source

3P-301 A Codon-based Model for Evolution of Protein-coding DNA Sequences(The 46th Annual Meeting of the Biophysical Society of Japan)

, 2008
Sanzo Miyazawa
openalex   +2 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Efficient Searches in Protein Sequence Space Through AI-Driven Iterative Learning. [PDF]

Int J Mol Sci
Suárez-Martín I, Risso VA, Romero-Zaliz R, Sanchez-Ruiz JM.   +3 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Native Silk Fibers: Protein Sequence and Structure Influences on Thermal and Mechanical Properties. [PDF]

Biomacromolecules
Aikman EL, Eccles LE, Stoppel WL.
europepmc   +1 more source

Conserved domain structure of beta-neurexins. Unusual cleaved signal sequences in receptor-like neuronal cell-surface proteins.

, 1994
Yuri A. Ushkaryov, Y. Hata, Konstantin Ichtchenko, Carolyn R. Moomaw, S J Afendis, Clive A. Slaughter, T C Südhof   +6 more
openalex   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source