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Computer analysis of protein sequences
1974Most interesting of all of the biochemical components of living organisms are proteins and nucleic acids because of their potential for diversity in structure and function and their key positions in the evolutionary feedback system of each species. Sequence studies on these molecules have been carried out for various purposes in a number of disciplines:
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Spectral Analysis of Protein Sequences
2006Analysis of protein sequences can avoid many problems inherently existing in the study of nucleotide sequences given the knowledge that DNA sequences contain all the information for regulating protein expression. This paper presents a spectral approach for calculating the similarity of protein sequences, which can be useful for the inferences of ...
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Computer analysis of DNA and protein sequences
European Journal of Biochemistry, 1991Some recent trends in the development of theoretical methods for DNA and protein sequence analysis are reviewed, with particular emphasis on the design of new databases, motif searches, sequence alignment algorithms and applications of neural networks.
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The chemistry of protein sequence analysis
2000N-terminal sequence analysis by Edman chemistry continues to play an important role in the structural analysis of proteins and peptides. Improvements in the sensitivity of the method have been achieved mainly at the level of increasing the sensitivity of the on-line analysis of PTH amino acids by RP-HPLC (reverse phase high performance chromatography).
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Protein Sequence Analysis: Automated Microsequencing
Science, 1983The automated microsequencing of proteins can now be carried out at the 5- to 10-picomoles (submicrogram) level on polypeptides obtained directly from one- and two-dimensional gel electrophoresis. The techniques are applicable to polypeptides ranging in size from small peptides (less than 10 residues) to large proteins (more than 1000 residues).
Hunkapiller, Michael W., Hood, Leroy E.
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New tools for protein sequence analysis
Trends in Biotechnology, 1990Analysis of protein sequence is an important tool in studies of both native and recombinant proteins. Novel techniques and instrumentation which facilitate determination of protein primary structure have recently been developed.
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Solid-phase protein sequence analysis
Nature, 1990The solutions to many protein analytical problems require flexible chemistries at a high sensitivity. Solid-phase sequence analysis is one way to eliminate limitations inherent in current methods.
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Analysis of sequence repeats of proteins in the PDB
Computational Biology and Chemistry, 2013Internal repeats in protein sequences play a significant role in the evolution of protein structure and function. Applications of different bioinformatics tools help in the identification and characterization of these repeats. In the present study, we analyzed sequence repeats in a non-redundant set of proteins available in the Protein Data Bank (PDB).
David Mary Rajathei, Samuel Selvaraj
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Compact Protein Sequencer for the C-Terminal Sequence Analysis of Peptides and Proteins
Analytical Biochemistry, 1993We describe the construction of a compact protein sequencer designed specifically for the C-terminal sequence analysis of peptides and proteins. This sequencer has a vertical flow path and is equipped with a continuous flow reactor (CFR). The flow paths for the various reagents and solvents have been minimized.
J M, Bailey, M, Rusnak, J E, Shively
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Granular Approach for Protein Sequence Analysis
2012Granular computing uses granules as basic units to compute with. Granules can be formed by either information abstraction or information decomposition. In this paper, we view information decomposition as a paradigm for processing data with complex structures.
Ying Xie 0001 +4 more
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