Results 191 to 200 of about 1,955,826 (316)

GeneScanner: profiling genetic variation across bacterial populations. [PDF]

Microb Genom
Kobras CM, Ko S, Raikwar PS, Aguilar-Sanjuan B, Jolley KA, Sheppard SK.   +5 more
europepmc   +1 more source

Sequence analysis and confirmation of type IV pili-associated proteins PilY1, PilW and PilV in Acidithiobacillus thiooxidans [PDF]

, 2018
Elvia Alfaro-Saldaña, O. Araceli Hernández-Sánchez, Araceli Patrón‐Soberano, Marizel Astello-García, José Alfredo Tirado Méndez, J. Viridiana García‐Meza   +5 more
openalex   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Fusion protein condensate formation via coiled-coil domains. [PDF]

Protein Sci
Narayan OP, Liu L, Scheller K, Humphrey C, Dong J, Guan J.   +5 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Large-scale statistical dissection of sequence-derived biochemical features distinguishing soluble and insoluble proteins. [PDF]

PLoS One
Vu NHH, Nguyen BL.
europepmc   +1 more source

Global analysis of bovine milk protein variants using multi-breed DNA sequence data

Ying Liu, Etske Bijl, Junxin Gao, Rayner González-Prendes, Martien A. M. Groenen, Juha Kantanen, Catarina Ginja, Nasser Ghanem, Donald R. Kugonza, Mahlako Makgahlela, Henk Bovenhuis, Richard P. M. A. Crooijmans   +11 more
openalex   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Heuristic multi-site optimization for protein sequence design using Masked Protein Language Models. [PDF]

PLoS Comput Biol
Wang L, Wang Y, Qiu C, Xiao L, Liu X, Chen J.   +5 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source