Results 241 to 250 of about 4,957,023 (387)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Molecular Identification and Pathogenicity of a Chilli Veinal Mottle Virus Isolate from Sichuan, China. [PDF]

Int J Mol Sci
Chen C, Lu D, Lin X, Zhou X, Yang X.
europepmc   +1 more source

Sequence Analysis of the Gene Region Encoding ESAT-6, Ag85B, and Ag85C Proteins from Clinical Isolates of Mycobacterium tuberculosis

, 2016
Ni Made Mertaniasih, Didik Handijatno, Agnes Dwi Sis Perwitasari, Desak Nyoman Surya Suameitria Dewi, Much Zaenal Fanani, Ika Qurrotul Afifah   +5 more
openalex   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Cross-linking mass spectrometry for structure analysis of the intrinsically disordered Tau and phosphorylated Tau protein. [PDF]

PLoS Comput Biol
Arsene C, Gates A, Römmert AK, Märtens A, Faustinelli V, Luckau L, O'Connor G.   +6 more
europepmc   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Transformer Learning in Sequence-Based Drug Design Depends on Compound Memorization and Similarity of Sequence-Compound Pairs. [PDF]

Mol Inform
Bajorath J.
europepmc   +1 more source

Cluster Analysis for Protein Sequences

AbstractThis paper presents a comprehensive analysis of MMseqs2 clusters and traditional machine learning (ML) clustering algorithms, including KMeans and Hierarchical clusterings, in terms of protein sequences. The analyses are validated experimentally.
openaire   +1 more source

Low Level Sequence Variant Analysis of Recombinant Proteins: An Optimized Approach

, 2012
Anne Zeck, Jörg T. Regula, Vincent Larraillet, Björn Mautz, Oliver Popp, Ulrich Göpfert, Frank Wiegeshoff, Ulrike E. E. Vollertsen, Ingo H. Gorr, Hans Koll, Apollon Papadimitriou   +10 more
openalex   +2 more sources

Sequence analysis and confirmation of type IV pili-associated proteins PilY1, PilW and PilV in Acidithiobacillus thiooxidans [PDF]

, 2018
Elvia Alfaro-Saldaña, O. Araceli Hernández-Sánchez, Araceli Patrón‐Soberano, Marizel Astello-García, José Alfredo Tirado Méndez, J. Viridiana García‐Meza   +5 more
openalex   +1 more source