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Protein Sequence Analysis: Automated Microsequencing
Science, 1983The automated microsequencing of proteins can now be carried out at the 5- to 10-picomoles (submicrogram) level on polypeptides obtained directly from one- and two-dimensional gel electrophoresis. The techniques are applicable to polypeptides ranging in size from small peptides (less than 10 residues) to large proteins (more than 1000 residues).
Hunkapiller, Michael W., Hood, Leroy E.
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PROTEAN: Protein Sequence Analysis and Prediction
Molecular Biotechnology, 2000The archaeal, bacterial, andeukaryotic genome projects have overwhelmed our ability to experimentally elucidate the function of each novel gene and gene product. To a certain extent, protein functional assignments can be derived via sequence similarity measures and direct primary sequence analysis using methods to predict hydropathy, secondary ...
T. Plasterer
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Gene Analysis Techniques, 1987
There has been a rapid increase in the number of available protein sequences derived from gene-sequence information. Computer-based sequence analysis of proteins is gaining in importance as an analytical tool. With the help of these analyses such sequences may be characterized and some insights gained into their probable role in the system.
D, Chatterjee, J V, Maizel
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There has been a rapid increase in the number of available protein sequences derived from gene-sequence information. Computer-based sequence analysis of proteins is gaining in importance as an analytical tool. With the help of these analyses such sequences may be characterized and some insights gained into their probable role in the system.
D, Chatterjee, J V, Maizel
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Basic Protein Sequence Analysis
Current Protocols in Molecular Biology, 2005AbstractPrediction of molecular function of proteins has become an important task in the genomics era. A wide variety of sequence analysis tools are available to biologists for this task. We have selected one or two primary protocols for tasks such as domain detection, subcellular localization, and motif detection.
Nandini, Krishnamurthy +1 more
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Hydrophobicity Profiles for Protein Sequence Analysis
Current Protocols in Protein Science, 1995AbstractHydrophobic interactions are a major force in protein folding and numerous hydropathy scales have been developed to quantify the relative hydrophobicity of the amino acids. Hydropathy profiles can be used to examine the surface features of proteins in order to generate hypotheses that can be confirmed experimentally.
S R, Krystek, W J, Metzler, J, Novotny
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Solid-phase protein sequence analysis
Nature, 1990The solutions to many protein analytical problems require flexible chemistries at a high sensitivity. Solid-phase sequence analysis is one way to eliminate limitations inherent in current methods.
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Computational Methods for Protein Sequence Analysis
Current Protocols in Protein Science, 1995AbstractThis unit is presented as a guide to addressing the issue of what to do with a protein sequence once it is obtained. A theoretical background for protein sequence analysis is provided first, followed by a discussion of matrix methods for sequence comparison ().
G, Michaels, R, Garian
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Gene/Protein Sequence Analysis
2008The advent of automated high throughput DNA sequencing methods has strongly enabled genome sequencing strategies, culminating in determination of the entire human genome (1,2). An enormous amount of DNA sequence data are available and databases still grow exponentially (see Fig. 22.1). Analysis of this overwhelming amount of data, including hundreds of
Rehm, BHA, Reinecke, F
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Protein Sequence Analysis by Proximities
2016Sequence data are widely used to get a deeper insight into biological systems. From a data analysis perspective they are given as a set of sequences of symbols with varying length. In general they are compared using nonmetric score functions. In this form the data are nonstandard, because they do not provide an immediate metric vector space and their ...
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Computer analysis of protein sequences
1974Most interesting of all of the biochemical components of living organisms are proteins and nucleic acids because of their potential for diversity in structure and function and their key positions in the evolutionary feedback system of each species. Sequence studies on these molecules have been carried out for various purposes in a number of disciplines:
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