Results 161 to 170 of about 133,461 (307)

Entwicklung von chemischen Initiatoren der Dimerisierung von HaloTag und SNAP‐Tag zur Untersuchung von Signaltransduktion induziert durch Rezeptor‐Oligomerisierung

Angewandte Chemie, EarlyView.
Die Kontrolle von Protein‐Interaktionen ist entscheidend für das Verständnis von Signaltransduktionsprozessen. Antikörperbasierte Methoden stoßen dabei an ihre Grenzen, doch chemische Dimerisierungsinduktoren (CIDs), die HaloTags und SNAP‐Tags nutzen, ermöglichen eine präzise Steuerung.
Michael Trumpp, Blaise Gatin‐Fraudet, Kjell Bruckmann, Wiktor Burdzinski, Kilian Roßmann, Joshua Levitz, Petra Knaus, Jerome Jatzlau, Johannes Broichhagen   +8 more
wiley   +1 more source

Novel kinase-activating genetic events in non-small cell lung carcinomas. [PDF]

Explor Target Antitumor Ther
Preobrazhenskaya EV, Mulkidjan RS, Zagrebin FA, Romanko AA, Saitova ES, Korzun PR, Binnatova JO, Tiurin VI, Bizin IV, Imyanitov EN.   +9 more
europepmc   +1 more source

Developing HaloTag and SNAP‐Tag Chemical Inducers of Dimerization to Probe Receptor Oligomerization and Downstream Signaling

Angewandte Chemie International Edition, EarlyView.
Controlling protein interactions is key to studying signaling. Antibody methods have limits, but chemical inducers of dimerization (CIDs) using HaloTags and SNAP‐Tags offer precise control. We present CIDs to covalently link heteromers with varied linkers and a FRET‐based sensor.
Michael Trumpp, Blaise Gatin‐Fraudet, Kjell Bruckmann, Wiktor Burdzinski, Kilian Roßmann, Joshua Levitz, Petra Knaus, Jerome Jatzlau, Johannes Broichhagen   +8 more
wiley   +1 more source

Proteomic surveys of the mouse heart unveil cardiovascular responses to nitric oxide/cGMP signaling deficiencies. [PDF]

Commun Biol
Mohanty I, Fazelinia H, Raimo S, Ding H, Spruce L, Symeonidou M, Tenopoulou M, Ichinose F, Yamashita H, Shimokawa H, Masato T, Doulias PT, Ischiropoulos H.   +12 more
europepmc   +1 more source

Positive Regulation of IκB Kinase Signaling by Protein Serine/Threonine Phosphatase 2A [PDF]

, 2005
Arlene E. Kray, Robert S. Carter, Kevin N. Pennington, Rey J. Gomez, Laura E. Sanders, Joan M. Llanes, Wasif N. Khan, Dean W. Ballard, Brian E. Wadzinski   +8 more
openalex   +1 more source

Hepatic gluconeogenesis and regulatory mechanisms in lactating ruminants: A literature review

Animal Research and One Health, EarlyView.
phosphoenolpyruvate carboxy kinase, FBP1, and glucose‐6‐phosphatase are key rate‐limiting enzymes that determine the efficiency of gluconeogenesis. The main substrate for gluconeogenesis in the liver of ruminants is propionate, which provides more than 60% of the carbon source for gluconeogenesis.
Guoyan Wang, Yuanyuan Zhu, Dingping Feng, Junhu Yao, Yangchun Cao, Lu Deng   +5 more
wiley   +1 more source

PknB and STP as potential targets of luteolin in combating Trueperella pyogenes infections. [PDF]

Sci Rep
Guo Y, Su H, Yu L, Wang Y, Tian C, Zhang D, Guo Y, Liu M.   +7 more
europepmc   +1 more source

FLR-4, a Novel Serine/Threonine Protein Kinase, Regulates Defecation Rhythm inCaenorhabditis elegans [PDF]

, 2005
Masaya Takeuchi, Yuri Kobayashi, Koutarou D. Kimura, Takeshi Ishihara, Isao Katsura   +4 more
openalex   +1 more source

TRIB3 suppresses milk fatty acids metabolism by inhibiting p‐AKT/PPARG signaling in goat mammary epithelial cells

Animal Research and One Health, EarlyView.
In this study, it revealed that TRIB3 could mediate the transcriptional activity of PPARG, inhibit the phosphorylation of akt, and reduce the expression of lipid metabolism‐related genes, thus inhibiting TAG synthesis and affecting fatty acid composition.
Xinglong Gong, Tan Pan, Tiantian Xiong, Yifan Zhu, Juan J. Loor, Chengming Han, Yifan Li, Huan Lei, Jun Luo, Cong Li   +9 more
wiley   +1 more source

Functional kinome profiling reveals brain protein kinase signaling pathways and gene networks altered by acute voluntary exercise in rats. [PDF]

PLoS One
Lee CM, Nguyen J, Pope B, Imami AS, Ryan VWG, Sahay S, Mathis V, Pulvender P, Eby HM, Arvay T, Alganem K, Wegman-Points L, McCullunsmith R, Yuan LL.   +13 more
europepmc   +1 more source