Citrus Flavonoids as Antimicrobials
Citrus flavonoids are powerful and versatile antimicrobials whose mechanism of action often involves disruption of the bacterial membrane, thereby minimizing antimicrobial resistance. This study provides a unified perspective. ABSTRACT Citrus flavonoids are highly bioactive compounds exerting numerous health benefits including anticancer, antioxidant ...
Rosaria Ciriminna+6 more
wiley +1 more source
HstK, a cyanobacterial protein with both a serine/threonine kinase domain and a histidine kinase domain: implication for the mechanism of signal transduction [PDF]
Vincent Phalip+2 more
openalex +1 more source
The Molecular Toolbox for Linkage Type‐Specific Analysis of Ubiquitin Signaling
Modification of proteins and other biomolecules with ubiquitin regulates virtually all aspects of eukaryotic cell biology. Ubiquitin can be attached to substrates as a monomer or as an array of polyubiquitin chains with defined linkages between the ubiquitin moieties.
Julian Koch+3 more
wiley +1 more source
Role of RNA modifications in carcinogenesis and carcinogen damage response
Abstract The field of epitranscriptomics encompasses the study of post‐transcriptional RNA modifications and their regulatory enzymes. Among the numerous RNA modifications, N6‐methyladenosine (m6A) has been identified as the most common internal modification of messenger RNA (mRNA).
Michelle Verghese+2 more
wiley +1 more source
PhosNetVis: a web-based tool for fast kinase-substrate enrichment analysis and interactive 2D/3D network visualizations of phosphoproteomics data [PDF]
Protein phosphorylation involves the reversible modification of a protein (substrate) residue by another protein (kinase). Liquid chromatography-mass spectrometry studies are rapidly generating massive protein phosphorylation datasets across multiple conditions.
arxiv
ABSTRACT Ovarian cancer (OC) is a deadly disease and lacks a precise marker for diagnosis worldwide. Our previous work has shown the overexpression of flotillin‐1 (FLOT1) in OC tissue. To improve diagnostic sensitivity and accuracy, we evaluated the serum level of FLOT1 in OC patients and found that the serum concentration of FLOT1 as well as CA125 was
Bin Guan+7 more
wiley +1 more source
The rasGAP-binding protein, Dok-1, mediates activin signaling via serine/threonine kinase receptors [PDF]
Noriko Yamakawa
openalex +1 more source
In Vitro Psilocybin Synthesis by Co‐Immobilized Enzymes
Advanced clinical trials investigate the Psilocybe magic mushroom natural product psilocybin as a treatment against major depressive disorder. Currently, synthetic material is used to meet the demand for legitimate pharmaceutical purposes. Here, we report an in vitro approach to biocatalytically produce psilocybin on a solid‐phase matrix charged with ...
Tim Schäfer+7 more
wiley +1 more source
A non-radioactive method for the assay of many serine/threonine-specific protein kinases [PDF]
Heike Ross+2 more
openalex +1 more source