Results 11 to 20 of about 191,213 (357)

Viral Serine/Threonine Protein Kinases [PDF]

Journal of Virology, 2011
ABSTRACT Phosphorylation represents one the most abundant and important posttranslational modifications of proteins, including viral proteins. Virus-encoded serine/threonine protein kinases appear to be a feature that is unique to large DNA viruses.
Thary, Jacob, Céline, Van den Broeke, Herman W, Favoreel   +2 more
openaire   +2 more sources

Phosphorylation of the chromatin binding domain of KSHV LANA. [PDF]

PLoS Pathogens, 2012
The Kaposi sarcoma associated herpesvirus (KSHV) latency associated nuclear antigen (LANA) is expressed in all KSHV associated malignancies and is essential for maintenance of KSHV genomes in infected cells.
Crystal Woodard, Meir Shamay, Gangling Liao, Jian Zhu, Ai Na Ng, Renfeng Li, Rob Newman, Hee-Sool Rho, Jianfei Hu, Jun Wan, Jiang Qian, Heng Zhu, S Diane Hayward   +12 more
doaj   +1 more source

Molecular Basis for Ser/Thr Specificity in PKA Signaling

Cells, 2020
cAMP-dependent protein kinase (PKA) is the major receptor of the second messenger cAMP and a prototype for Ser/Thr-specific protein kinases. Although PKA strongly prefers serine over threonine substrates, little is known about the molecular basis of this
Matthias J. Knape, Maximilian Wallbott, Nicole C. G. Burghardt, Daniela Bertinetti, Jan Hornung, Sven H. Schmidt, Robin Lorenz, Friedrich W. Herberg   +7 more
doaj   +1 more source

An atlas of substrate specificities for the human serine/threonine kinome

Nature, 2023
Protein phosphorylation is one of the most widespread post-translational modifications in biology^ 1 , 2 . With advances in mass-spectrometry-based phosphoproteomics, 90,000 sites of serine and threonine phosphorylation have so far been identified, and ...
Jared L. Johnson, Tomer M. Yaron, Emily M Huntsman, A. Kerelsky, Junho Song, Amit Regev, Ting Lin, Katarina M Liberatore, Daniel M. Cizin, Benjamin M. Cohen, N. Vasan, Yilun Ma, Konstantin Krismer, Jaylissa Torres Robles, Bert van de Kooij, Anne E. van Vlimmeren, Nicole Andrée-Busch, N. Käufer, M. Dorovkov, A. Ryazanov, Y. Takagi, Edward R. Kastenhuber, M. Goncalves, B. Hopkins, O. Elemento, D. Taatjes, A. Maucuer, A. Yamashita, A. Degterev, Mohamed Uduman, Jingyi Lu, Sean D. Landry, Bin Zhang, Ian Cossentino, R. Linding, J. Blenis, P. Hornbeck, B. Turk, M. Yaffe, L. Cantley   +39 more
semanticscholar   +1 more source

A framework for classification of prokaryotic protein kinases. [PDF]

PLoS ONE, 2010
BACKGROUND: Overwhelming majority of the Serine/Threonine protein kinases identified by gleaning archaeal and eubacterial genomes could not be classified into any of the well known Hanks and Hunter subfamilies of protein kinases.
Nidhi Tyagi, Krishanpal Anamika, Narayanaswamy Srinivasan   +2 more
doaj   +1 more source

Tyrosine phosphorylation of the BRI1 receptor kinase occurs via a posttranslational modification and is activated by the juxtamembrane domain

Frontiers in Plant Science, 2012
In metazoans, receptor kinases control many essential processes related to growth and development and response to the environment. The receptor kinases in plants and animals are structurally similar but evolutionarily distinct and thus while most animal ...
Man-Ho eOh, Steven D. Clouse, Steven C. Huber, Steven C. Huber   +3 more
doaj   +1 more source

Proteínas quinases: características estruturais e inibidores químicos Kinase protein: structural features and chemical inhibitors

Química Nova, 2009
Protein kinases are one of the largest protein families and they are responsible for regulation of a great number of signal transduction pathways in cells, through the phosphorylation of serine, threonine, or tyrosine residues.
Bárbara V. Silva, Bruno A. C. Horta, Ricardo Bicca de Alencastro, Angelo C. Pinto   +3 more
doaj   +1 more source

Role of serine/threonine protein phosphatase PrpN in the life cycle of Bacillus anthracis.

PLoS Pathogens, 2022
Reversible protein phosphorylation at serine/threonine residues is one of the most common protein modifications, widely observed in all kingdoms of life.
Aakriti Gangwal, Nitika Sangwan, Neha Dhasmana, Nishant Kumar, Chetkar Chandra Keshavam, Lalit K Singh, Ankur Bothra, Ajay K Goel, Andrei P Pomerantsev, Stephen H Leppla, Yogendra Singh   +10 more
doaj   +1 more source

STRUCTURE, ACTIVATION AND BIOLOGICAL EFFECTS OF AKT OR PROTEIN KINASE B [PDF]

Romanian Journal of Medical Practice, 2019
AKT or protein kinase B is a serine / threonine kinase that plays a crucial role in cell proliferation, survival, growth, and glucose metabolism. So far, there have been discovered 3 isoforms of AKT, the most widespread in the tissues is AKT1.
Daniela Miricescu, Alexandra Totan, Constantin Stefani, Iulia-Ioana Stănescu, Ana Maria Alexandra Stanescu, Ioana Ruxandra Rusu, Radu Radulescu, George Costin Rusu, Maria Greabu   +8 more
doaj   +1 more source

The Subcellular Proteome of a Planctomycetes Bacterium Shows That Newly Evolved Proteins Have Distinct Fractionation Patterns

Frontiers in Microbiology, 2021
The Planctomycetes bacteria have unique cell architectures with heavily invaginated membranes as confirmed by three-dimensional models reconstructed from FIB-SEM images of Tuwongella immobilis and Gemmata obscuriglobus.
Christian Seeger, Karl Dyrhage, Mayank Mahajan, Anna Odelgard, Sara Bergström Lind, Siv G. E. Andersson   +5 more
doaj   +1 more source