Results 21 to 30 of about 142,067 (264)

Phosphoproteomics analysis of a clinical Mycobacterium tuberculosis Beijing isolate: Expanding the mycobacterial phosphoproteome catalogue

Frontiers in Microbiology, 2015
Reversible protein phosphorylation, regulated by protein kinases and phosphatases, mediates a switch between protein activity and cellular pathways that contribute to a large number of cellular processes.
Suereta eFortuin, Gisele eTomazella, Naga eNagayaryan, Samantha eSampson, Nicolaas eGey van Pittius, Nelson Da Cruz Soares, Harald eWiker, Gustavo eDe Souza, Robin Mark Warren   +8 more
doaj   +1 more source

Correlated mutation analysis on the catalytic domains of serine/threonine protein kinases. [PDF]

PLoS ONE, 2009
BACKGROUND:Protein kinases (PKs) have emerged as the largest family of signaling proteins in eukaryotic cells and are involved in every aspect of cellular regulation.
Feng Xu, Pan Du, Hongbo Shen, Hairong Hu, Qi Wu, Jun Xie, Long Yu   +6 more
doaj   +1 more source

Case report: A novel frameshift mutation in BRSK2 causes autism in a 16-year old Chinese boy

Frontiers in Psychiatry, 2023
Serine/threonine protein kinases are involved in axon formation and neuronal polarization and have recently been implicated in autism spectrum disorder (ASD) and neurodevelopmental disorders (NDD).
Yu Hu, Yu Hu, Miao Li, Miao Li, Yanmei Shen, Tianyun Wang, Tianyun Wang, Tianyun Wang, Tianyun Wang, Qiwei Liu, Qiwei Liu, Qiwei Liu, Zhonghua Lu, Zhonghua Lu, Hong Wang, Hong Wang, Xuerong Luo, Lixin Yang, Lixin Yang   +18 more
doaj   +1 more source

Detection of HBV C Protein Phosphorylation in the Cell

Bio-Protocol, 2015
Among the seven serines and one threonine in the carboxyl-terminus of HBV C protein, all but one (serine 183) appear in the context of RxxS/T consensus phosphoacceptor motifs and also overlap with other consensus motifs, such as S/TP, RS, SPRRR, RRRS/T ...
Jaesung Jung, Kyongmin Kim
doaj   +1 more source

Structural basis for ALK2/BMPR2 receptor complex signaling through kinase domain oligomerization

Nature Communications, 2021
Bone morphogenetic protein (BMP) receptors are single pass transmembrane serine/threonine kinases that form tetrameric complexes comprised of two type I and two type II BMP receptors.
Christopher Agnew, Pelin Ayaz, Risa Kashima, Hanna S. Loving, Prajakta Ghatpande, Jennifer E. Kung, Eric S. Underbakke, Yibing Shan, David E. Shaw, Akiko Hata, Natalia Jura   +10 more
doaj   +1 more source

Bioinformatic search of plant microtubule-and cell cycle related serine-threonine protein kinases

BMC Genomics, 2010
A bioinformatic search was carried for plant homologues of human serine-threonine protein kinases involved in regulation of cell division and microtubule protein phosphorylation (SLK, PAK6, PAK7, MARK1, MAST2, TTBK1, TTBK2, AURKA, PLK1, PLK4 and PASK). A
Nyporko Alexey, Matusov Vadym G, Yemets Alla I, Nadezhdina Elena S, Karpov Pavel A, Shashina Nadezhda, Blume Yaroslav B   +6 more
doaj   +1 more source

Genome-wide survey of putative Serine/Threonine protein kinases in cyanobacteria

BMC Genomics, 2007
Background Serine/threonine kinases (STKs) have been found in an increasing number of prokaryotes, showing important roles in signal transduction that supplement the well known role of two-component system.
Guan Xiangyu, Zhao Fangqing, Zhang Xiaowen, Yang Yu, Liang Chengwei, Qin Song   +5 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source